Abstract：
:Neoadjuvant cisplatin-based combination chemotherapy is an established standard for resectable muscle-invasive bladder cancer, a disease with a pattern of predominantly distant and early recurrences. Pathologic complete remission appears to be an intermediate surrogate for survival when employing combination chemotherapy. Moreover, baseline host and tumor tissue studies may enable the discovery of biomarkers predictive of activity. The neoadjuvant setting also provides a window of opportunity to evaluate novel biologic agents or rational combinations of biologic agents to obtain a signal of biologic activity. The residual tumor after neoadjuvant therapy may be exploited to study the mechanism of action and resistance. Cisplatin-ineligible patients warrant the evaluation of tolerable neoadjuvant regimens. Given that bladder cancer is characterized by initial localized presentation in the vast majority of cases, the paradigm of neoadjuvant therapy may expedite the development of novel systemic agents.
journal_name
Curr Urol Repjournal_title
Current urology reportsauthors
Sonpavde G,Sternberg CNdoi
10.1007/s11934-012-0236-2subject
Has Abstractpub_date
2012-04-01 00:00:00pages
136-46issue
2eissn
1527-2737issn
1534-6285journal_volume
13pub_type
杂志文章,评审abstract：:Recent studies have cast doubt on the reliability of serum total prostate-specific antigen as a biomarker for the detection and prognosis of prostate cancer. Biomarkers that can identify those men at risk for clinically significant prostate cancer are desperately needed. The search for biomarkers that may improve the ...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-005-0004-7
更新日期：2005-05-01 00:00:00
abstract：:Adrenal cortical carcinoma is a relatively uncommon malignancy that represents a significant clinical challenge for the development of optimal treatment strategies. Historically, successful treatment has relied upon rapid identification of the lesion, accurate staging with diagnostic imaging, and complete surgical ext...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-007-0024-6
更新日期：2007-01-01 00:00:00
abstract：:Currently in the USA, one name is added to the organ transplant waiting list every 15 min. As this list grows rapidly, fewer than one-third of waiting patients can receive matched organs from donors. Unfortunately, many patients who require a transplant have to wait for long periods of time, and many of them die befor...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-017-0650-6
更新日期：2017-01-01 00:00:00
abstract：:Chronic nonbacterial prostatitis, or urological chronic pelvic pain syndrome (UCPPS), remains a common and often challenging disorder to evaluate and treat. Employing a more holistic approach, including urological therapy, physical therapy, and psychosocial perspectives, may be more appropriate for most patients. Grow...
journal_title：Current urology reports
pub_type： 杂志文章
doi：10.1007/s11934-009-0047-2
更新日期：2009-07-01 00:00:00
abstract：:Bulking therapy for stress urinary incontinence in women continues to evolve from the standpoint of material science. Several new materials have recently been subjected to clinical trials with the aim of assessing efficacy and safety of these agents for possible device registration. These new additions run the gamut o...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-006-0012-2
更新日期：2006-09-01 00:00:00
abstract：:The most important change in urology during the past decade was the development of minimally invasive surgery, particularly laparoscopy. However, the main drawback of laparoscopy is a steep learning curve, which results from the significant changes in the surgical environment. Although laparoscopy can provide importan...
journal_title：Current urology reports
pub_type： 杂志文章
doi：10.1007/s11934-003-0040-0
更新日期：2003-04-01 00:00:00
abstract：PURPOSE OF REVIEW:The goal of this paper is to describe the pathophysiology of adult nocturnal enuresis and develop a generalized approach for evaluation and treatment. RECENT FINDINGS:Although nocturnal enuresis (NE) impacts a significant proportion of the adult population, research on this topic remains lacking. In ...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-020-00983-2
更新日期：2020-06-06 00:00:00
abstract：:Because the number of patients requiring oral anticoagulation (OA) is steadily growing, more and more patients requiring surgical treatment of benign prostatic hyperplasia (BPH) are on OA. Laser treatment of BPH was said to offer a higher quality of hemostasis than transurethral resection of the prostate (TURP). Thus,...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-010-0115-7
更新日期：2010-07-01 00:00:00
abstract：PURPOSE OF REVIEW:From health systems to individuals, nephrolithiasis is economically burdensome. The aim of the current paper is to characterize the financial burden of disease associated with nephrolithiasis with an emphasis on investigating treatment modality economic efficiency. RECENT FINDINGS:For small volume pr...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-020-00971-6
更新日期：2020-03-31 00:00:00
abstract：:Medical treatments for lower urinary tract symptoms due to benign prostatic hyperplasia are frequently associated with changes in sexual function. While these medications are generally well-tolerated and have both reduced and delayed more invasive surgical options, the ramifications of long-term chronic use are largel...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-014-0441-2
更新日期：2014-10-01 00:00:00
abstract：:Complementary and alternative medicine (CAM) has recently attracted national attention in the United States because of its widespread use and associated cost. CAM covers a broad spectrum of healing philosophies and approaches. Despite its widespread use, little is known about its safety, efficacy, cost effectiveness, ...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-001-0084-y
更新日期：2001-06-01 00:00:00
abstract：:Health information technology (HIT) is expected to transform the delivery of health care in the United States, but implementation and adoption vary widely across settings, specialties, and geographies. Significant barriers to high-level adoption persist despite federal incentives to hospitals and health-care providers...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-013-0356-3
更新日期：2013-12-01 00:00:00
abstract：:Patients diagnosed with prostate cancer who elect to pursue active treatment of their disease must choose among the many available treatment alternatives. Several treatment options now exist for similar-stage disease (clinical T1-3N0M0), including radical prostatectomy, external beam radiation, prostate brachytherapy ...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-000-0034-0
更新日期：2000-05-01 00:00:00
abstract：:This paper is aimed at focusing on the nerve-sparing aspect of the robotic prostatectomy. It reviews the existing principles and presents the arguments based on robotic fresh cadaver dissections and from actual robotic prostatectomy cases. ...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-005-0080-8
更新日期：2005-03-01 00:00:00
abstract：:Nodal staging is important in prostate cancer treatment. While surgical lymph node dissection is the classic method of determining whether lymph nodes harbor malignancy, this is a very invasive technique. Current noninvasive approaches to identifying malignant lymph nodes are limited. Conventional imaging methods rely...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-015-0505-y
更新日期：2015-05-01 00:00:00
abstract：:Approximately one in seven American men will be diagnosed with prostate cancer during his lifetime, and at least 50% of newly diagnosed patients will present with low-risk disease. In the last decade, the decision-making paradigm for management has shifted due to high rates of disease detection and overtreatment, attr...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-015-0507-9
更新日期：2015-06-01 00:00:00
abstract：PURPOSE OF REVIEW:Inflatable penile prosthesis (IPP) is a treatment for erectile dysfunction. IPPs have undergone improvements; however, post-surgical infections still occur. Furthermore, the type of pathogens infecting the implants has changed recently from Gram-positive to Gram-negative bacteria and fungi due to adva...
journal_title：Current urology reports
pub_type： 历史文章,杂志文章,评审
doi：10.1007/s11934-019-0874-8
更新日期：2019-01-30 00:00:00
abstract：:The most common form of prostatitis is National Institutes of Health category III, also known as chronic abacterial prostatitis/chronic pelvic pain syndrome. The search for effective and durable therapy for this condition remains frustrating for both patients and physicians. A new approach incorporating a neurobahavio...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-000-0051-z
更新日期：2000-08-01 00:00:00
abstract：PURPOSE OF REVIEW:There are an estimated 33 million men and women with overactive bladder (OAB) in the USA. Despite the prevalence of OAB, it remains a frequently misdiagnosed condition. OAB has shared symptomatology with other common urologic conditions, namely recurrent urinary tract infections (UTIs). Here, we will ...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-018-0839-3
更新日期：2018-09-13 00:00:00
abstract：:Bladder cancer is the second commonest urinary tract malignancy with 70-80 % being non-muscle invasive (NMIBC) at diagnosis. Patients with high-risk NMIBC (T1/Tis, with high grade/G3, or CIS) represent a challenging group as they are at greater risk of recurrence and progression. Intravesical Bacilli Calmette-Guerin (...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-016-0625-z
更新日期：2016-09-01 00:00:00
abstract：:Bladder outlet obstruction (BOO) in women can be either anatomic or functional. Anatomic causes for BOO are often readily apparent by history and physical exam. On the other hand, causes for functional obstruction, including dysfunctional voiding, primary bladder neck obstruction, and detrusor-external sphincter dyssy...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-012-0267-8
更新日期：2012-10-01 00:00:00
abstract：:Global improvements in water quality, management of infectious diseases, and other medical therapeutics have resulted in a growing population of healthy aging men. One obligate anatomic consequence of aging for these men is the development of benign prostatic hyperplasia (BPH) with secondary bladder outlet obstruction...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-014-0403-8
更新日期：2014-05-01 00:00:00
abstract：:Most children born with spina bifida, the most common disabling congenital abnormality, have normal renal function. If left untreated, more than half of these children will have serious renal deterioration by age 5. This deterioration is secondary to hostile neurogenic changes of the bladder. Renal development should ...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-008-0027-y
更新日期：2008-03-01 00:00:00
abstract：PURPOSE OF REVIEW:Laparoscopic kidney surgery is commonly used for living donor, partial, and total tumor nephrectomy. The successful emergence of laparoscopic technique was justified by the many benefits offered such as reduced blood loss, tissue trauma, pain, and hospital stay. However, this comes at the expense of p...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-018-0757-4
更新日期：2018-01-18 00:00:00
abstract：:Within the past 25 years, lasers have transitioned from merely destructive or ablative tools to those with reconstructive uses. It has been shown that the application of laser thermal energy to tissue will result in welding of the approximated areas. Furthermore, the addition of protein solder and chromophores (tissue...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-003-0058-3
更新日期：2003-02-01 00:00:00
abstract：:Urinary tract infections (UTI) remain one of the most prevalent and frustrating morbidities for neurogenic bladder patients, and death attributed to urosepsis in the spinal cord injury (SCI) patient is higher when compared to the general population. Risk factors include urinary stasis, high bladder pressures, bladder ...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-014-0433-2
更新日期：2014-09-01 00:00:00
abstract：:Aging can be associated with an abnormal decline in testosterone production, mainly due to pituitary failure, and is reflected by low serum testosterone concentrations. Manifestations of testosterone deficiency can be subtle, can be misinterpreted as consequences of normal aging, and include lack of libido and energy,...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-000-0013-5
更新日期：2000-12-01 00:00:00
abstract：PURPOSE OF REVIEW:Molecular characterization of cancer allows us to understand oncogenesis and clinical prognosis as well as facilitates development of biomarkers and treatment. Our aim was to review the current literature on genomic characterization of bladder cancer, and how far we are in implementing genomics into c...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-020-0960-y
更新日期：2020-03-13 00:00:00
abstract：PURPOSE OF REVIEW:Urolithiasis is a disease of prevalence across the world and up to a quarter of patients present with multiple stones. Most procedures carried out in this scenario are staged; however, there is a growing body of evidence to suggest bilateral simultaneous (BS) procedures are safe. We performed a system...
journal_title：Current urology reports
pub_type： 杂志文章
doi：10.1007/s11934-019-0877-5
更新日期：2019-02-21 00:00:00
abstract：:Several minimally invasive approaches to treatment of ureteropelvic junction obstruction are now in the urologist's armamentarium. This review provides in-depth analysis of endopyelotomy, endopyeloplasty, and laparoscopic pyeloplasty and suggests a treatment algorithm for proper patient selection to improve efficacy a...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-007-0064-y
更新日期：2007-03-01 00:00:00
