Abstract:
:Adrenal cortical carcinoma is a relatively uncommon malignancy that represents a significant clinical challenge for the development of optimal treatment strategies. Historically, successful treatment has relied upon rapid identification of the lesion, accurate staging with diagnostic imaging, and complete surgical extirpation. Although the framework of a successful treatment paradigm still relies on these steps, advances in diagnostic imaging have led to increased accuracy in diagnosis, and advances in laparoscopic surgical technique have served to reduce morbidity for patients facing treatment. This review focuses on a discussion of advances in modalities for the diagnosis and treatment of adrenal cortical carcinoma amenable to curative therapy. Patients that present with metastatic or locally advanced disease generally are treated with mitotane-based chemotherapy with or without the addition of cytotoxic drugs. Contemporary results of this treatment approach are presented in this review as well as a discussion of further directions for the treatment of patients with advanced disease.
journal_name
Curr Urol Repjournal_title
Current urology reportsauthors
Fulmer BRdoi
10.1007/s11934-007-0024-6subject
Has Abstractpub_date
2007-01-01 00:00:00pages
77-82issue
1eissn
1527-2737issn
1534-6285journal_volume
8pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:Male urethral stricture disease is characterized by the formation of scar tissue within the urethra resulting in lower urinary tract symptoms, infection, and potentially kidney dysfunction. There is significant variability in clinical practice for the treatment of urethral stricture. We sought to summ...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-018-0771-6
更新日期:2018-02-26 00:00:00
abstract:PURPOSE OF REVIEW:Bladder cancer care is costly due to long surveillance periods for non-muscle-invasive bladder cancer (NMIBC) and comorbidities associated with the surgical treatment of muscle-invasive bladder cancer (MIBC). We reviewed current evidence-based practices and propose quality metrics for NMIBC and MIBC. ...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-018-0856-2
更新日期:2018-10-24 00:00:00
abstract::Each of the three most common contemporary treatments for localized prostate cancer, radical prostatectomy, external beam radiotherapy, and brachytherapy, can have adverse effects on sexual health. Sexual health outcome can be improved by treatment-specific factors, such as the use of nerve-sparing technique during ra...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-004-0039-1
更新日期:2004-06-01 00:00:00
abstract::For patients with muscle-invasive bladder cancer, the decision to undergo radical cystectomy or bladder preservation treatment must incorporate survival differences, toxicity, and quality of life. Our objective was to review patient-reported outcomes for bladder preservation treatment with a focus on patients eligible...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-015-0547-1
更新日期:2015-11-01 00:00:00
abstract::There is substantial variability in the extent of the node dissection performed during radical cystectomy for bladder cancer. Here, we review the diagnostic assessment of lymph node metastasis and the prognostic and therapeutic benefit for pelvic node dissection for bladder cancer. A review of the applicable urologic ...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-012-0235-3
更新日期:2012-04-01 00:00:00
abstract::Correct staging of prostate cancer at initial diagnosis, as well as accurate staging and tumor localization with biochemical recurrence, remains generally inaccurate with current imaging techniques. Newer modalities are being investigated to accurately identify patients with prostate cancer at different stages of dise...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-006-0018-9
更新日期:2006-05-01 00:00:00
abstract::Numerous surgeries have been proposed for the treatment of genuine stress incontinence, with the goals to improve functional outcome and decrease complications and their associated morbidity. Two new, minimally invasive procedures, transvaginal retropubic urethropexy and transvaginal Cooper's ligament sling, are revie...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-996-0018-9
更新日期:2001-10-01 00:00:00
abstract::At present, it is reasonable to counsel all patients, as well as family members of patients, who have a palpable varicocele about the long-term risks for impaired fertility. Currently, no one can predict with absolute certainty if any adolescent with a varicocele will be at risk for future infertility. Based on existi...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-002-0019-2
更新日期:2002-04-01 00:00:00
abstract::Overactive bladder syndrome continues to be a significant burden for the general population. Current first-line medical therapy often includes antimuscarinic medications designed for overactive bladder. Poor efficacy and significant side effects of these antimuscarinic medications have left patients and physicians loo...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-010-0134-4
更新日期:2010-09-01 00:00:00
abstract:PURPOSE OF REVIEW:To discuss considerations and current evidence for the diagnosis and management of vaginal mesh exposures following female mesh-augmented anti-incontinence and pelvic organ prolapse surgery. RECENT FINDINGS:Since the introduction of mesh into female pelvic surgery, various applications have been repo...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-020-01002-0
更新日期:2020-10-30 00:00:00
abstract::Surgical treatment of long urethral stricture disease remains one of the most challenging problems in urology. In recent years there has been continuous discussion with regard to the etiology, location, length, and management of extensive urethral stricture disease. Various tissues such as genital and extragenital ski...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-014-0424-3
更新日期:2014-08-01 00:00:00
abstract::Nodal staging in prostate cancer is suboptimal both with respect to current imaging modalities and pelvic lymph node dissection, and thus other techniques are being explored. Lymphotropic nanoparticle-enhanced MRI, also called magnetic resonance lymphography (MRL), is a technique that has shown high sensitivity (65-92...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-013-0389-7
更新日期:2014-03-01 00:00:00
abstract::Adolescents with varicoceles represent a large and heterogeneous group. This patient population has rapidly changing hormonal levels and may present at different stages of physical and pubertal development. At the same time, the adolescent varicocele is becoming a more widely appreciated and diagnosed entity with an e...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-009-0026-7
更新日期:2009-03-01 00:00:00
abstract::Lipoxygenases oxidatively metabolize polyunsaturated fatty acids to a rich spectrum of biologically active products. One enzyme of the lipoxygenase family, Arachidonate 15-lipoxygenase-1 (arachidonate:oxygen 15-oxidoreductase, EC 1.13.11.33), is implicated in several forms of epithelial cell cancers, and provides a ra...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-002-0066-8
更新日期:2002-06-01 00:00:00
abstract:PURPOSE OF REVIEW:For many diseases that place a large burden on our health care system, men often have worse health outcomes than women. As the largest single provider of health care to men in the USA, the Veterans Health Administration (VA) has the potential to serve as leader in the delivery of improved men's health...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-017-0733-4
更新日期:2017-09-18 00:00:00
abstract::The cholinergic system of the bladder includes muscarinic receptors distributed to detrusor myocytes and structures within mucosa including bladder afferent (sensory) nerves. The receptors have been shown to be involved in afferent signaling from the bladder, but it has not been established to what extent effects on t...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-008-0079-z
更新日期:2008-11-01 00:00:00
abstract::Bladder outlet obstruction (BOO) in women can be either anatomic or functional. Anatomic causes for BOO are often readily apparent by history and physical exam. On the other hand, causes for functional obstruction, including dysfunctional voiding, primary bladder neck obstruction, and detrusor-external sphincter dyssy...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-012-0267-8
更新日期:2012-10-01 00:00:00
abstract::Several minimally invasive approaches to treatment of ureteropelvic junction obstruction are now in the urologist's armamentarium. This review provides in-depth analysis of endopyelotomy, endopyeloplasty, and laparoscopic pyeloplasty and suggests a treatment algorithm for proper patient selection to improve efficacy a...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-007-0064-y
更新日期:2007-03-01 00:00:00
abstract::Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a prevalent disease for which there is no standardized therapy. Traditional treatments have included antibiotics, α-blockers, and anti-inflammatories, but those have not proven to be efficacious therapies through many clinical trials. Alternative therapies,...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-011-0188-y
更新日期:2011-08-01 00:00:00
abstract:PURPOSE OF REVIEW:The symptoms of lower urinary tract dysfunction (LUTD) including urinary incontinence, frequency, and urgency are among the most common reasons children are referred to pediatric urologists. Despite this, the workup for LUTD is often time consuming and a source of frustration for patients, parents, an...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-018-0784-1
更新日期:2018-04-06 00:00:00
abstract::In recent years, more attention has turned to the use of patient-reported outcomes in clinical trials to assess treatment efficacy in overactive bladder syndrome (OAB). The challenge for investigators and clinicians is how to choose among the many available health-related quality-of-life questionnaires. This article p...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-008-0064-6
更新日期:2008-09-01 00:00:00
abstract:PURPOSE OF THE REVIEW:To update the most relevant literature regarding complex vascular cases in kidney transplant setting involving the graft, especially during the harvesting procedure and back-table preparation from the subsequent implant. RECENT FINDINGS:Challenging situations affecting the kidney graft such as mu...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-020-0955-8
更新日期:2020-01-31 00:00:00
abstract::Erectile dysfunction (ED) is common after radical prostatectomy (RP). ED has a negative impact on health-related quality of life. Penile rehabilitation is defined as the use of any drug or device at or after RP to maximize erectile function recovery. The purpose of penile rehabilitation is the prevention of corpus cav...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-009-0037-4
更新日期:2009-05-01 00:00:00
abstract:PURPOSE OF REVIEW:This article explores the anatomy, management options, and outcomes of pelvic organ prolapse with a female cystectomy patient. RECENT FINDINGS:There is a lack of data on surgical management outcomes for prolapse following radical cystectomy. However, most case series from tertiary referral centers sh...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-019-0941-1
更新日期:2019-10-15 00:00:00
abstract::Currently in the USA, one name is added to the organ transplant waiting list every 15 min. As this list grows rapidly, fewer than one-third of waiting patients can receive matched organs from donors. Unfortunately, many patients who require a transplant have to wait for long periods of time, and many of them die befor...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-017-0650-6
更新日期:2017-01-01 00:00:00
abstract::Complications of locally advanced prostate cancer are often overlooked in the overall treatment of prostate cancer, can have significant morbidity, and can provide a challenge for the treating urologist. Despite advances in early detection and treatment of prostate cancer, as many as 10% of patients present with or de...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-007-0008-6
更新日期:2007-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Molecular characterization of cancer allows us to understand oncogenesis and clinical prognosis as well as facilitates development of biomarkers and treatment. Our aim was to review the current literature on genomic characterization of bladder cancer, and how far we are in implementing genomics into c...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-020-0960-y
更新日期:2020-03-13 00:00:00
abstract::Benign prostatic hyperplasia (BPH) is a common cause of lower urinary tract symptoms (LUTS) in men. Patients with BPH often present with a combination of obstructive and overactive bladder (OAB) symptoms. It is postulated that bladder outlet obstruction (BOO) from BPH results in concomitant OAB symptoms through ischem...
journal_title:Current urology reports
pub_type: 杂志文章
doi:10.1007/s11934-013-0363-4
更新日期:2013-12-01 00:00:00
abstract::The conservative treatment of stress urinary incontinence for women has many facets. Each intervention may have value and patients may benefit from simple, reversible recommendations and techniques versus invasive surgery. Starting with a thorough history, lifestyle modifications may lead to decreased incontinence. De...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-005-0056-8
更新日期:2005-09-01 00:00:00
abstract::High-intensity focused ultrasound (HIFU) is an emerging, noninvasive, local treatment of prostate cancer with 15 years of clinical experience, during which about 30,000 HIFU treatments have been performed worldwide. In this paper, we review relevant publications regarding the means by which new and old prostate cancer...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-011-0184-2
更新日期:2011-06-01 00:00:00