Abstract:
:Benign prostatic hyperplasia (BPH) is a common cause of lower urinary tract symptoms (LUTS) in men. Patients with BPH often present with a combination of obstructive and overactive bladder (OAB) symptoms. It is postulated that bladder outlet obstruction (BOO) from BPH results in concomitant OAB symptoms through ischemic induced variations in the response to neurotransmitters of both the detrusor and the urothelium. This altered response leads to the pathologic activation of the micturition reflex, generating sensory dysfunction and involuntary bladder contractions. Alpha-1 adrenoceptor antagonists (alpha-blockers) and 5-alpha reductase inhibitors (5-ARIs) are commonly used to treat the BOO caused by BPH. Anticholinergic agents are frequently used to treat concurrently OAB symptoms caused by the BOO. Unfortunately, anticholinergic medications demonstrate bothersome side effects and a theoretical risk of urinary retention. Basic science and clinical research has led to the development of a new class of pharmaceuticals for the treatment of overactive bladder with diminished risk of urinary retention and lacking many anticholinergic side effects. This novel compound, mirabegron (Mybertriq, Astellas Pharma US, Inc.), is a β₃-adrenoceptor agonist and represents a promising new class of oral agents designed for the treatment of OAB symptoms, with minimal effect on voiding.
journal_name
Curr Urol Repjournal_title
Current urology reportsauthors
Suarez O,Osborn D,Kaufman M,Reynolds WS,Dmochowski Rdoi
10.1007/s11934-013-0363-4subject
Has Abstractpub_date
2013-12-01 00:00:00pages
580-4issue
6eissn
1527-2737issn
1534-6285journal_volume
14pub_type
杂志文章abstract::The use of injectable bulking agents into the submucosal layer of the pediatric urinary tract continues to grow. Treatment strategies for vesicoureteral reflux and urinary incontinence have changed with the introduction of dextranomer/hyaluronic acid as a minimally invasive option. Socially and medically debilitating ...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-006-0074-1
更新日期:2006-03-01 00:00:00
abstract::In recent years, more attention has turned to the use of patient-reported outcomes in clinical trials to assess treatment efficacy in overactive bladder syndrome (OAB). The challenge for investigators and clinicians is how to choose among the many available health-related quality-of-life questionnaires. This article p...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-008-0064-6
更新日期:2008-09-01 00:00:00
abstract::Bladder outlet obstruction (BOO) in women can be either anatomic or functional. Anatomic causes for BOO are often readily apparent by history and physical exam. On the other hand, causes for functional obstruction, including dysfunctional voiding, primary bladder neck obstruction, and detrusor-external sphincter dyssy...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-012-0267-8
更新日期:2012-10-01 00:00:00
abstract::Testosterone (T) deficiency syndrome (TDS) is a prevalent condition, commonly managed with exogenous T. Despite an abundance of T formulations, alternative treatments are often sought for various reasons. To evaluate outcomes of alternative therapies, a PubMed search was performed of all publications that included men...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-014-0417-2
更新日期:2014-07-01 00:00:00
abstract::Molecular imaging of prostate cancer is in a dynamic phase of development. Currently approved techniques are limited and researchers have been working on novel agents to improve accuracy in targeting and detecting prostate tumors. In addition, the complexity of various prostate cancer states also contributes to the ch...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-016-0575-5
更新日期:2016-03-01 00:00:00
abstract::Inflatable penile prosthesis (IPP) is an effective treatment for erectile dysfunction in patients' refractory to oral or injectable treatment. While the rate of infection has decreased over the past decade, it is still the most feared complication of IPP placement. Here, we assemble possible patient and surgical facto...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-015-0554-2
更新日期:2015-12-01 00:00:00
abstract::Within the past 25 years, lasers have transitioned from merely destructive or ablative tools to those with reconstructive uses. It has been shown that the application of laser thermal energy to tissue will result in welding of the approximated areas. Furthermore, the addition of protein solder and chromophores (tissue...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-003-0058-3
更新日期:2003-02-01 00:00:00
abstract:PURPOSE OF REVIEW:We reviewed the literature to determine what role, if any, radical prostatectomy should play in the treatment of high-risk and/or node-positive prostate cancer. RECENT FINDINGS:The AUA, NCCN, and EAU all include radical prostatectomy as a treatment option for high-risk prostate cancer based on eviden...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-017-0703-x
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:Vesico-vaginal fistulae (VVF) remain the most prevalent genitourinary fistula detrimentally impacting quality of life. PURPOSE OF THE REVIEW:The purpose of this review is to examine relevant literature on management of VVF. RECENT FINDINGS:Obstructed labor is the leading cause of VVF in the developing worl...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-017-0708-5
更新日期:2017-08-01 00:00:00
abstract::Author Siamak Daneshmand would like to note that this article published in Current Urology Reports inadvertently did not disclose financial information that could possibly be a conflict of interest. ...
journal_title:Current urology reports
pub_type: 杂志文章,已发布勘误
doi:10.1007/s11934-019-0890-8
更新日期:2019-04-05 00:00:00
abstract:PURPOSE OF THE REVIEW:To update the most relevant literature regarding complex vascular cases in kidney transplant setting involving the graft, especially during the harvesting procedure and back-table preparation from the subsequent implant. RECENT FINDINGS:Challenging situations affecting the kidney graft such as mu...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-020-0955-8
更新日期:2020-01-31 00:00:00
abstract::Focal therapy for prostate cancer has emerged an interesting concept as a less morbid option for the treatment of localized low-risk disease. Despite the growing interest in focal therapy, this approach has not yet gained sufficient popularity nor provided enough data to be discussed outside the experimental applicati...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-010-0100-1
更新日期:2010-05-01 00:00:00
abstract::Overactive bladder syndrome continues to be a significant burden for the general population. Current first-line medical therapy often includes antimuscarinic medications designed for overactive bladder. Poor efficacy and significant side effects of these antimuscarinic medications have left patients and physicians loo...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-010-0134-4
更新日期:2010-09-01 00:00:00
abstract::Nodal staging is important in prostate cancer treatment. While surgical lymph node dissection is the classic method of determining whether lymph nodes harbor malignancy, this is a very invasive technique. Current noninvasive approaches to identifying malignant lymph nodes are limited. Conventional imaging methods rely...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-015-0505-y
更新日期:2015-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Intratumor heterogeneity is an inherent event in tumor development that is receiving much attention in the last years since it is responsible for most failures of current targeted therapies. The purpose of this review is to offer clinicians an updated insight of the multiple manifestations of a comple...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-018-0754-7
更新日期:2018-01-27 00:00:00
abstract::Adrenal cortical carcinoma is a relatively uncommon malignancy that represents a significant clinical challenge for the development of optimal treatment strategies. Historically, successful treatment has relied upon rapid identification of the lesion, accurate staging with diagnostic imaging, and complete surgical ext...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-007-0024-6
更新日期:2007-01-01 00:00:00
abstract:PURPOSE OF REVIEW:While recurrence after primary treatment of prostate cancer (PCa) is not uncommon, there is currently no consensus on the most appropriate management after radiation treatment failure. This article seeks to explore the currently utilized modalities for salvage treatment for radiorecurrent PCa. We focu...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-017-0709-4
更新日期:2017-08-01 00:00:00
abstract::Positioning injuries in the perioperative period are one of the inherent risks of surgery, but particularly in robot-assisted urologic surgery, and can result in often unrecognized morbidity. Injuries such as upper or lower extremity peripheral neuropathies occur via neural mechanisms and injuries such as compartment ...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-014-0398-1
更新日期:2014-04-01 00:00:00
abstract::Congenital abnormalities, cancer, trauma, infection, inflammation, iatrogenic injuries, and other conditions may lead to genitourinary organ damage or loss, requiring eventual reconstruction. Tissue engineering follows the principles of cell transplantation, materials science, and engineering toward the development of...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-001-0030-z
更新日期:2001-02-01 00:00:00
abstract:PURPOSE OF REVIEW:The symptoms of lower urinary tract dysfunction (LUTD) including urinary incontinence, frequency, and urgency are among the most common reasons children are referred to pediatric urologists. Despite this, the workup for LUTD is often time consuming and a source of frustration for patients, parents, an...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-018-0784-1
更新日期:2018-04-06 00:00:00
abstract::To decrease side effects observed after high-intensity focused ultrasound (HIFU) treatment for localized prostate cancer and to re-establish normal micturition in a patient population that often presents with concomitant prostate enlargement, the impact of a combined transurethral resection of the prostate (TURP) and ...
journal_title:Current urology reports
pub_type: 临床试验,杂志文章
doi:10.1007/s11934-003-0077-0
更新日期:2003-06-01 00:00:00
abstract::Most adrenal tumors are found incidentally and appear as small solitary nodules on abdominal imaging. Occasionally, work-up demonstrates multifocal or bilateral adrenal tumors. Certain patients are predisposed to multiple lesions, such as those with hereditary forms of pheochromocytoma as seen in von Hippel-Lindau dis...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-001-0021-0
更新日期:2001-02-01 00:00:00
abstract::Nodal staging in prostate cancer is suboptimal both with respect to current imaging modalities and pelvic lymph node dissection, and thus other techniques are being explored. Lymphotropic nanoparticle-enhanced MRI, also called magnetic resonance lymphography (MRL), is a technique that has shown high sensitivity (65-92...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-013-0389-7
更新日期:2014-03-01 00:00:00
abstract::Despite accumulating evidence that inflammation may affect the development of prostate cancer, responsible causes of intraprostatic inflammation remain elusive. This review presents epidemiologic literature on infections, particularly sexually transmitted and other ascending urogenital infections, as possible causes o...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-008-0042-z
更新日期:2008-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Laparoscopic kidney surgery is commonly used for living donor, partial, and total tumor nephrectomy. The successful emergence of laparoscopic technique was justified by the many benefits offered such as reduced blood loss, tissue trauma, pain, and hospital stay. However, this comes at the expense of p...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-018-0757-4
更新日期:2018-01-18 00:00:00
abstract::Laparoscopic surgery was originally developed by gynecologists and general surgeons. Based on their experience, the first successful laparoscopic procedures in urology were performed transperitoneally. However, this novel technique transformed traditionally retroperitoneal procedures into transperitoneal procedures, g...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-004-0020-z
更新日期:2004-04-01 00:00:00
abstract::Symptoms such as overactive bladder represent disorders of bladder control. Functional brain scanning by positron emission tomography and functional magnetic resonance imaging suggest that normal control is exerted by a network of regions in the emotional nervous system, including periaqueductal gray, thalamus, insula...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-004-0081-z
更新日期:2004-10-01 00:00:00
abstract::Laparoscopic adrenalectomy is considered to be the standard of care for the surgical excision of the adrenal gland. Since the initial report of laparoscopic adrenalectomy in 1992, it has evolved into a feasible and reproducible minimally invasive procedure for benign adrenal tumors. Transperitoneal and retroperitoneal...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-005-0070-x
更新日期:2005-02-01 00:00:00
abstract::Peyronie's disease (PD) is the occurrence of a fibrous inelastic scar of the tunica albuginea of the penis. It is a relatively common disorder among men, with a reported prevalence of 3% to 8%. It is often associated with penile pain, anatomical deformities in the erect state, and difficulty with intromission. Because...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-011-0212-2
更新日期:2011-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Patient-reported outcome measures (PROMs) are tools that are widely used by clinicians and researchers across different medical specialties. In this review, we examine the use of PROMs in the evaluation of female pelvic floor disorders (PFD). RECENT FINDINGS:PROM development in the assessment of urin...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-019-0888-2
更新日期:2019-03-27 00:00:00