Abstract：
:Testosterone (T) deficiency syndrome (TDS) is a prevalent condition, commonly managed with exogenous T. Despite an abundance of T formulations, alternative treatments are often sought for various reasons. To evaluate outcomes of alternative therapies, a PubMed search was performed of all publications that included men with TDS from 1990 through October 2013, with results summarized. Proposed mechanisms of action were also reviewed to provide a pathophysiologic basis for reported outcomes. Nonpharmacologic therapies that increase endogenous T are weight loss, exercise, and varicocelectomy, while medications used off-label include aromatase inhibitors, human chorionic gonadotropin, and selective estrogen receptor modulators. All reported therapies increase T, while changes in estradiol and adverse events vary by therapeutic class. Although limited data preclude direct comparisons between therapies, exercise and weight loss alone or in combination with medications may be considered first line. The role for surgical therapy in TDS remains undefined and requires further study.
journal_name
Curr Urol Repjournal_title
Current urology reportsauthors
Trost LW,Khera Mdoi
10.1007/s11934-014-0417-2subject
Has Abstractpub_date
2014-07-01 00:00:00pages
417issue
7eissn
1527-2737issn
1534-6285journal_volume
15pub_type
杂志文章,评审abstract：PURPOSE OF REVIEW:Bladder cancer care is costly due to long surveillance periods for non-muscle-invasive bladder cancer (NMIBC) and comorbidities associated with the surgical treatment of muscle-invasive bladder cancer (MIBC). We reviewed current evidence-based practices and propose quality metrics for NMIBC and MIBC. ...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-018-0856-2
更新日期：2018-10-24 00:00:00
abstract：:Partial nephrectomy has become an accepted treatment of cT1 renal masses as it provides improved long-term renal function compared to radical nephrectomy (Campbell et al. J Urol. 182:1271-9, 2009). Hilar clamping is utilized to help reduce bleeding and improve visibility during tumor resection. However, concern over r...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-016-0596-0
更新日期：2016-05-01 00:00:00
abstract：:Benign prostatic hyperplasia (BPH) is a common cause of lower urinary tract symptoms (LUTS) in men. Patients with BPH often present with a combination of obstructive and overactive bladder (OAB) symptoms. It is postulated that bladder outlet obstruction (BOO) from BPH results in concomitant OAB symptoms through ischem...
journal_title：Current urology reports
pub_type： 杂志文章
doi：10.1007/s11934-013-0363-4
更新日期：2013-12-01 00:00:00
abstract：PURPOSE OF REVIEW:Inflatable penile prosthesis (IPP) is a treatment for erectile dysfunction. IPPs have undergone improvements; however, post-surgical infections still occur. Furthermore, the type of pathogens infecting the implants has changed recently from Gram-positive to Gram-negative bacteria and fungi due to adva...
journal_title：Current urology reports
pub_type： 历史文章,杂志文章,评审
doi：10.1007/s11934-019-0874-8
更新日期：2019-01-30 00:00:00
abstract：:The benefit that patients with overactive bladder (OAB) experience with conservative management is an important aspect in the evaluation of this therapy. The first-line options include behavioral interventions, and several techniques are available. Clinical research indicates amelioration of individual symptoms with t...
journal_title：Current urology reports
pub_type： 杂志文章
doi：10.1007/s11934-012-0262-0
更新日期：2012-10-01 00:00:00
abstract：:The prostate-specific antigen (PSA) era has increased the rates of prostate cancer detection and treatment, while reducing the risk of death from prostate cancer in the US. Image-guided prostate biopsy techniques have led to stage migration and the detection and treatment of lower risk prostate cancers. Improved techn...
journal_title：Current urology reports
pub_type： 杂志文章
doi：10.1007/s11934-012-0285-6
更新日期：2012-12-01 00:00:00
abstract：:Adolescents with varicoceles represent a large and heterogeneous group. This patient population has rapidly changing hormonal levels and may present at different stages of physical and pubertal development. At the same time, the adolescent varicocele is becoming a more widely appreciated and diagnosed entity with an e...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-009-0026-7
更新日期：2009-03-01 00:00:00
abstract：:Urgency and urinary urge incontinence are troublesome and complex symptoms that can complicate the diagnosis and treatment of stress urinary incontinence. Despite this fact, first-line intervention frequently is directed toward the incompetent bladder neck using surgical approaches. Persistent urgency or detrusor inst...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-004-0065-z
更新日期：2004-12-01 00:00:00
abstract：:Vaginal vault prolapse is a challenging form of pelvic organ prolapse that occurs in combination with cystocele, rectocele, or enterocele in nearly 75% of affected patients. Clinical presentation will vary depending on the associated defects. Any successful therapy for vaginal vault prolapse will depend on a thorough ...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-007-0038-0
更新日期：2007-09-01 00:00:00
abstract：:The increased detection of incidental renal masses has introduced new challenges into the management of patients with newly discovered renal masses. Much interest has been focused on the diagnostic accuracy and the prognostic ability of imaging studies. These studies have elucidated trends that can guide management bu...
journal_title：Current urology reports
pub_type： 杂志文章
doi：10.1007/s11934-009-0004-0
更新日期：2009-01-01 00:00:00
abstract：:Congenital abnormalities, cancer, trauma, infection, inflammation, iatrogenic injuries, and other conditions may lead to genitourinary organ damage or loss, requiring eventual reconstruction. Tissue engineering follows the principles of cell transplantation, materials science, and engineering toward the development of...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-001-0030-z
更新日期：2001-02-01 00:00:00
abstract：PURPOSE OF REVIEW:Intratumor heterogeneity is an inherent event in tumor development that is receiving much attention in the last years since it is responsible for most failures of current targeted therapies. The purpose of this review is to offer clinicians an updated insight of the multiple manifestations of a comple...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-018-0754-7
更新日期：2018-01-27 00:00:00
abstract：:Each of the three most common contemporary treatments for localized prostate cancer, radical prostatectomy, external beam radiotherapy, and brachytherapy, can have adverse effects on sexual health. Sexual health outcome can be improved by treatment-specific factors, such as the use of nerve-sparing technique during ra...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-004-0039-1
更新日期：2004-06-01 00:00:00
abstract：:Functional magnetic resonance imaging (fMRI) techniques enable noninvasive assessment of renal function. Diffusion-weighted imaging, diffusion tensor imaging, blood oxygen level-dependent MRI, magnetic resonance elastography, and arterial spin labeling are some of the emerging techniques that have potential to investi...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-011-0229-6
更新日期：2012-02-01 00:00:00
abstract：:The lack of reliable imaging tools in detecting prostate cancer makes a random biopsy still the standard of care to detect prostate cancer. To reduce the number of cores during a biopsy and therefore the risk of biopsy-related complications, an imaging tool which provides reliable guided biopsies is required. Transrec...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-013-0392-z
更新日期：2014-03-01 00:00:00
abstract：:Overactive bladder syndrome continues to be a significant burden for the general population. Current first-line medical therapy often includes antimuscarinic medications designed for overactive bladder. Poor efficacy and significant side effects of these antimuscarinic medications have left patients and physicians loo...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-010-0134-4
更新日期：2010-09-01 00:00:00
abstract：:Neoadjuvant cisplatin-based combination chemotherapy is an established standard for resectable muscle-invasive bladder cancer, a disease with a pattern of predominantly distant and early recurrences. Pathologic complete remission appears to be an intermediate surrogate for survival when employing combination chemother...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-012-0236-2
更新日期：2012-04-01 00:00:00
abstract：:Impotence is often accompanied by loss of phallic length. To enhance penile prosthesis surgery, it is possible to perform simple adjuvant procedures that will increase perceived or true length. This article presents an overview of these techniques, which may be categorized as involving removal or fixation of tissue ab...
journal_title：Current urology reports
pub_type： 杂志文章
doi：10.1007/s11934-009-0075-y
更新日期：2009-11-01 00:00:00
abstract：:Peyronie's disease (PD) is the occurrence of a fibrous inelastic scar of the tunica albuginea of the penis. It is a relatively common disorder among men, with a reported prevalence of 3% to 8%. It is often associated with penile pain, anatomical deformities in the erect state, and difficulty with intromission. Because...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-011-0212-2
更新日期：2011-12-01 00:00:00
abstract：PURPOSE OF REVIEW:This review provides a critical literature overview of the risks and benefits of transplantectomy in patients with a failed allograft. Additionally, it offers a summary of related problems, primarily alloantibody sensitization in the event of nephrectomy and immunosuppression weaning. RECENT FINDINGS...
journal_title：Current urology reports
pub_type： 杂志文章
doi：10.1007/s11934-020-0957-6
更新日期：2020-01-18 00:00:00
abstract：:The objective of this review is to discuss the main goals of pelvic organ prolapse repair. Pelvic organ prolapse symptoms are variable, and prolapse degree does not necessarily correlate with perceived symptoms or other associated conditions including urinary, defecatory, and sexual dysfunction. Treatment for pelvic o...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-013-0385-y
更新日期：2014-02-01 00:00:00
abstract：:Recent studies have cast doubt on the reliability of serum total prostate-specific antigen as a biomarker for the detection and prognosis of prostate cancer. Biomarkers that can identify those men at risk for clinically significant prostate cancer are desperately needed. The search for biomarkers that may improve the ...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-005-0004-7
更新日期：2005-05-01 00:00:00
abstract：PURPOSE OF REVIEW:The goal of this paper was to review the novel treatment modality of high-intensity transurethral directional ultrasound for prostate cancer. RECENT FINDINGS:Prostate cancer is a heterogeneous disease with some patients electing for active surveillance and focal therapies instead of definitive treatm...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-020-01020-y
更新日期：2021-01-06 00:00:00
abstract：:DNA microarray technology provides a means to examine large numbers of molecular changes related to a biological process in a high throughput manner. This review discusses plausible utilities of this technology in prostate cancer research, including definition of prostate cancer predisposition, global profiling of gen...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-002-0011-x
更新日期：2002-02-01 00:00:00
abstract：:Inflatable penile prosthesis (IPP) is an effective treatment for erectile dysfunction in patients' refractory to oral or injectable treatment. While the rate of infection has decreased over the past decade, it is still the most feared complication of IPP placement. Here, we assemble possible patient and surgical facto...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-015-0554-2
更新日期：2015-12-01 00:00:00
abstract：PURPOSE OF REVIEW:Urethral strictures that are refractory to initial management present unique challenges to the reconstructive surgeon. Treatment trends have shifted as new tissue resources are becoming available. There is renewed interest in old methods as skill and technique have improved. We describe the scope of t...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-018-0769-0
更新日期：2018-02-26 00:00:00
abstract：PURPOSE OF THE REVIEW:To update the most relevant literature regarding complex vascular cases in kidney transplant setting involving the graft, especially during the harvesting procedure and back-table preparation from the subsequent implant. RECENT FINDINGS:Challenging situations affecting the kidney graft such as mu...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-020-0955-8
更新日期：2020-01-31 00:00:00
abstract：:Correct staging of prostate cancer at initial diagnosis, as well as accurate staging and tumor localization with biochemical recurrence, remains generally inaccurate with current imaging techniques. Newer modalities are being investigated to accurately identify patients with prostate cancer at different stages of dise...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-006-0018-9
更新日期：2006-05-01 00:00:00
abstract：:Significant clinical and basic science advances in the field of sexual medicine have facilitated investigation of the link between endothelial dysfunction and erectile dysfunction. Most sexual medicine practitioners accept the premise that in aging men with risk factors such as increased waist circumference, diabetes,...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-007-0054-0
更新日期：2007-11-01 00:00:00
abstract：:This article reviews the mechanisms by which vaginal surgery affects female sexual function and related pathophysiology to potential causes. The anatomy, neurovascular supply of the clitoris and introitus, and intrapelvic nerve supply are discussed as they apply to vaginal surgery. Methods to avoid neurovascular damag...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-004-0091-x
更新日期：2004-10-01 00:00:00
