The Failing Kidney Transplant Allograft. Transplant Nephrectomy: Current State-of-the-Art.

Abstract:

PURPOSE OF REVIEW:This review provides a critical literature overview of the risks and benefits of transplantectomy in patients with a failed allograft. Additionally, it offers a summary of related problems, primarily alloantibody sensitization in the event of nephrectomy and immunosuppression weaning. RECENT FINDINGS:Transplant nephrectomy has high morbidity and mortality rates. The morbidity of transplant nephrectomy (4.3 to 82%) is mostly due to hemorrhage or infection. Mortality rates range from 1.2 to 39%, and most are due to sepsis. Transvascular graft embolization has been described as a less invasive alternative technique for the management of symptomatic graft rejection, with minimal complications compared with transplantectomy. The number of patients with a failed allograft returning to dialysis is increasing. The role of allograft nephrectomy in the management of asymptomatic transplant failure is still controversial and up today continues to depend on the usual clinical practice of each institution. The less invasive transvascular embolization could have applicability in asymptomatic patients with the obvious lower morbidity and mortality rate.

journal_name

Curr Urol Rep

journal_title

Current urology reports

authors

Gómez-Dos-Santos V,Lorca-Álvaro J,Hevia-Palacios V,Fernández-Rodríguez AM,Diez-Nicolás V,Álvarez-Rodríguez S,Burgos JB,Guerrero CS,Burgos-Revilla FJ

doi

10.1007/s11934-020-0957-6

subject

Has Abstract

pub_date

2020-01-18 00:00:00

pages

4

issue

1

eissn

1527-2737

issn

1534-6285

pii

10.1007/s11934-020-0957-6

journal_volume

21

pub_type

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