Abstract：
:Erectile dysfunction (ED) often is caused by endothelial dysfunction and may be a sign that a patient has vascular disease elsewhere in the body. Risk factors for coronary artery disease such as lipid abnormalities, smoking, diabetes, and hypertension also are risk factors for ED. Oral therapy for ED, such as sildenafil, inhibits phosphodiesterase-5 (PDE-5) and the breakdown of cyclic guanosine monophosphate. PDE-5 inhibitors have been shown to be safe and effective for the therapy for ED, but remain contraindicated in patients receiving organic nitrates. These agents are mild vasodilators and are being investigated for their treatment potential for patients with pulmonary hypertension, heart failure, and endothelial dysfunction.
journal_name
Curr Urol Repjournal_title
Current urology reportsauthors
Kloner RAdoi
10.1007/s11934-003-0028-9keywords:
subject
Has Abstractpub_date
2003-12-01 00:00:00pages
466-71issue
6eissn
1527-2737issn
1534-6285journal_volume
4pub_type
杂志文章,评审abstract：PURPOSE OF REVIEW:Targeting PD-1/PD-L1 immune checkpoints is a new therapeutic tool in patients with locally advanced and metastatic clear cell renal cell carcinoma (CCRCC). The purpose of this review is to offer clinicians an updated translational insight into the current status of a therapeutic alternative that may i...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-019-0866-8
更新日期：2019-01-15 00:00:00
abstract：PURPOSE OF REVIEW:Bladder cancer care is costly due to long surveillance periods for non-muscle-invasive bladder cancer (NMIBC) and comorbidities associated with the surgical treatment of muscle-invasive bladder cancer (MIBC). We reviewed current evidence-based practices and propose quality metrics for NMIBC and MIBC. ...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-018-0856-2
更新日期：2018-10-24 00:00:00
abstract：PURPOSE OF REVIEW:Although benign, renal angiomyolipoma (AML) may lead to serious complications without appropriate management. The purpose of this review is to describe the role of and evidence for interventional radiology techniques in the management of patients with AML. RECENT FINDINGS:For patients with renal mass...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-017-0687-6
更新日期：2017-05-01 00:00:00
abstract：:The cholinergic system of the bladder includes muscarinic receptors distributed to detrusor myocytes and structures within mucosa including bladder afferent (sensory) nerves. The receptors have been shown to be involved in afferent signaling from the bladder, but it has not been established to what extent effects on t...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-008-0079-z
更新日期：2008-11-01 00:00:00
abstract：:Congenital abnormalities, cancer, trauma, infection, inflammation, iatrogenic injuries, and other conditions may lead to genitourinary organ damage or loss, requiring eventual reconstruction. Tissue engineering follows the principles of cell transplantation, materials science, and engineering toward the development of...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-001-0030-z
更新日期：2001-02-01 00:00:00
abstract：:The prostate-specific antigen (PSA) era has increased the rates of prostate cancer detection and treatment, while reducing the risk of death from prostate cancer in the US. Image-guided prostate biopsy techniques have led to stage migration and the detection and treatment of lower risk prostate cancers. Improved techn...
journal_title：Current urology reports
pub_type： 杂志文章
doi：10.1007/s11934-012-0285-6
更新日期：2012-12-01 00:00:00
abstract：:Bulking therapy for stress urinary incontinence in women continues to evolve from the standpoint of material science. Several new materials have recently been subjected to clinical trials with the aim of assessing efficacy and safety of these agents for possible device registration. These new additions run the gamut o...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-006-0012-2
更新日期：2006-09-01 00:00:00
abstract：PURPOSE OF REVIEW:Urolithiasis is a disease of prevalence across the world and up to a quarter of patients present with multiple stones. Most procedures carried out in this scenario are staged; however, there is a growing body of evidence to suggest bilateral simultaneous (BS) procedures are safe. We performed a system...
journal_title：Current urology reports
pub_type： 杂志文章
doi：10.1007/s11934-019-0877-5
更新日期：2019-02-21 00:00:00
abstract：:The inability of urologists to consistently and effectively treat men with chronic pelvic pain syndrome (CPPS), also known as chronic abacterial prostatitis, is a source of great frustration. Botulinum toxin (BTX), a potent neurotoxin, can act on most of the peripheral nerves of the pelvis through a variety of mechani...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-010-0118-4
更新日期：2010-07-01 00:00:00
abstract：:The conservative treatment of stress urinary incontinence for women has many facets. Each intervention may have value and patients may benefit from simple, reversible recommendations and techniques versus invasive surgery. Starting with a thorough history, lifestyle modifications may lead to decreased incontinence. De...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-005-0056-8
更新日期：2005-09-01 00:00:00
abstract：:The use of injectable bulking agents into the submucosal layer of the pediatric urinary tract continues to grow. Treatment strategies for vesicoureteral reflux and urinary incontinence have changed with the introduction of dextranomer/hyaluronic acid as a minimally invasive option. Socially and medically debilitating ...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-006-0074-1
更新日期：2006-03-01 00:00:00
abstract：:Adolescents with varicoceles represent a large and heterogeneous group. This patient population has rapidly changing hormonal levels and may present at different stages of physical and pubertal development. At the same time, the adolescent varicocele is becoming a more widely appreciated and diagnosed entity with an e...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-009-0026-7
更新日期：2009-03-01 00:00:00
abstract：:Overactive bladder (OAB) affects millions of people in the United States, and as the population ages, the prevalence of OAB will invariably increase. Conventional therapy for OAB includes behavioral modification and anticholinergic medication. OAB treatment comes with significant economic impact. With anticholinergic ...
journal_title：Current urology reports
pub_type： 杂志文章
doi：10.1007/s11934-009-0054-3
更新日期：2009-09-01 00:00:00
abstract：:Despite the proven efficacy of oral therapy for erectile dysfunction (ED), some patients are unable to take these medications because of drug interactions (ie, sildenafil and nitroglycerin) or a lack of response. Topical agents represent another minimally invasive option for the treatment of ED. This review discusses ...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-002-0100-x
更新日期：2002-12-01 00:00:00
abstract：PURPOSE OF REVIEW:This review provides a critical literature overview of the risks and benefits of transplantectomy in patients with a failed allograft. Additionally, it offers a summary of related problems, primarily alloantibody sensitization in the event of nephrectomy and immunosuppression weaning. RECENT FINDINGS...
journal_title：Current urology reports
pub_type： 杂志文章
doi：10.1007/s11934-020-0957-6
更新日期：2020-01-18 00:00:00
abstract：PURPOSE OF REVIEW:Intratumor heterogeneity is an inherent event in tumor development that is receiving much attention in the last years since it is responsible for most failures of current targeted therapies. The purpose of this review is to offer clinicians an updated insight of the multiple manifestations of a comple...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-018-0754-7
更新日期：2018-01-27 00:00:00
abstract：:Each of the three most common contemporary treatments for localized prostate cancer, radical prostatectomy, external beam radiotherapy, and brachytherapy, can have adverse effects on sexual health. Sexual health outcome can be improved by treatment-specific factors, such as the use of nerve-sparing technique during ra...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-004-0039-1
更新日期：2004-06-01 00:00:00
abstract：:Recent studies have cast doubt on the reliability of serum total prostate-specific antigen as a biomarker for the detection and prognosis of prostate cancer. Biomarkers that can identify those men at risk for clinically significant prostate cancer are desperately needed. The search for biomarkers that may improve the ...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-005-0004-7
更新日期：2005-05-01 00:00:00
abstract：PURPOSE OF REVIEW:Therapeutic options for the management of lower urinary tract symptoms (LUTS) secondary to benign prostatic enlargement (BPE) have considerably increased in recent years. However, the ideal timing to initiate medical treatment of LUTS/BPE has not been fully established. The aim of this review was to s...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-018-0823-y
更新日期：2018-07-09 00:00:00
abstract：:Impotence is often accompanied by loss of phallic length. To enhance penile prosthesis surgery, it is possible to perform simple adjuvant procedures that will increase perceived or true length. This article presents an overview of these techniques, which may be categorized as involving removal or fixation of tissue ab...
journal_title：Current urology reports
pub_type： 杂志文章
doi：10.1007/s11934-009-0075-y
更新日期：2009-11-01 00:00:00
abstract：:High-intensity focused ultrasound (HIFU) is an emerging, noninvasive, local treatment of prostate cancer with 15 years of clinical experience, during which about 30,000 HIFU treatments have been performed worldwide. In this paper, we review relevant publications regarding the means by which new and old prostate cancer...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-011-0184-2
更新日期：2011-06-01 00:00:00
abstract：PURPOSE OF REVIEW:There are an estimated 33 million men and women with overactive bladder (OAB) in the USA. Despite the prevalence of OAB, it remains a frequently misdiagnosed condition. OAB has shared symptomatology with other common urologic conditions, namely recurrent urinary tract infections (UTIs). Here, we will ...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-018-0839-3
更新日期：2018-09-13 00:00:00
abstract：:With the advent of intracytoplasmic injection, the management of azoospermia has become ever more important. Gametic manipulation to produce biological offspring is not feasible unless sperm from the azoospermic male patient is obtainable. This article provides an overview of the diagnosis and treatment of azoospermia...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-001-0038-4
更新日期：2001-12-01 00:00:00
abstract：:Increasing evidence recently has pointed toward a relationship between lower urinary tract symptoms (LUTS) and the presence of metabolic syndrome. This relationship has been supported by recent epidemiologic findings. Possible pathophysiologic links also have been proposed to explain the relationship between these two...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-996-0008-y
更新日期：2006-07-01 00:00:00
abstract：:Molecular imaging of prostate cancer is in a dynamic phase of development. Currently approved techniques are limited and researchers have been working on novel agents to improve accuracy in targeting and detecting prostate tumors. In addition, the complexity of various prostate cancer states also contributes to the ch...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-016-0575-5
更新日期：2016-03-01 00:00:00
abstract：:Complementary and alternative medicine (CAM) has recently attracted national attention in the United States because of its widespread use and associated cost. CAM covers a broad spectrum of healing philosophies and approaches. Despite its widespread use, little is known about its safety, efficacy, cost effectiveness, ...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-001-0084-y
更新日期：2001-06-01 00:00:00
abstract：:For patients with muscle-invasive bladder cancer, the decision to undergo radical cystectomy or bladder preservation treatment must incorporate survival differences, toxicity, and quality of life. Our objective was to review patient-reported outcomes for bladder preservation treatment with a focus on patients eligible...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-015-0547-1
更新日期：2015-11-01 00:00:00
abstract：:Because the number of patients requiring oral anticoagulation (OA) is steadily growing, more and more patients requiring surgical treatment of benign prostatic hyperplasia (BPH) are on OA. Laser treatment of BPH was said to offer a higher quality of hemostasis than transurethral resection of the prostate (TURP). Thus,...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-010-0115-7
更新日期：2010-07-01 00:00:00
abstract：:Medical treatments for lower urinary tract symptoms due to benign prostatic hyperplasia are frequently associated with changes in sexual function. While these medications are generally well-tolerated and have both reduced and delayed more invasive surgical options, the ramifications of long-term chronic use are largel...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-014-0441-2
更新日期：2014-10-01 00:00:00
abstract：:Urinary tract infections (UTI) remain one of the most prevalent and frustrating morbidities for neurogenic bladder patients, and death attributed to urosepsis in the spinal cord injury (SCI) patient is higher when compared to the general population. Risk factors include urinary stasis, high bladder pressures, bladder ...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-014-0433-2
更新日期：2014-09-01 00:00:00
