Abstract：
:Benign prostatic hyperplasia (BPH) is the most common urologic affliction in aging men, leading to adverse clinical outcomes in a significant proportion of the population. Serum prostate-specific antigen (PSA) has been established as a marker for prostate cancer for the past two decades but more recently has been recognized as an equally important marker of BPH presence and progression. Over this time, the discovery and study of multiple isoforms of PSA have led to even more sensitive and specific methods to differentiate BPH from prostate cancer. Herein we review the expression, processing, and biochemistry of PSA and its derivatives and discuss the potential of these isoforms, both individually and in combination, to serve as determinants of BPH severity and progression.
journal_name
Curr Urol Repjournal_title
Current urology reportsauthors
Levitt JM,Slawin KMdoi
10.1007/s11934-007-0072-ysubject
Has Abstractpub_date
2007-07-01 00:00:00pages
269-74issue
4eissn
1527-2737issn
1534-6285journal_volume
8pub_type
杂志文章,评审abstract：PURPOSE OF REVIEW:The majority of enhancing renal masses cannot be characterized through imaging as malignant or benign; however, such characterization could save patients from unnecessary surgery and/or biopsy and associated morbidity. Herein, we review the recent literature on the emerging use of 99mTc-MIBI SPECT/CT ...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-017-0737-0
更新日期：2017-09-12 00:00:00
abstract：:The development of a lymphocele after pelvic surgery is a well-documented complication, especially where pelvic lymph node dissection (PLND) is part of the operation. However, not all lymphoceles are symptomatic and require treatment. Most lymphoceles spontaneously resolve, and even lymphoceles that become symptomatic...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-014-0445-y
更新日期：2014-10-01 00:00:00
abstract：:Symptoms such as overactive bladder represent disorders of bladder control. Functional brain scanning by positron emission tomography and functional magnetic resonance imaging suggest that normal control is exerted by a network of regions in the emotional nervous system, including periaqueductal gray, thalamus, insula...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-004-0081-z
更新日期：2004-10-01 00:00:00
abstract：:Overactive bladder syndrome continues to be a significant burden for the general population. Current first-line medical therapy often includes antimuscarinic medications designed for overactive bladder. Poor efficacy and significant side effects of these antimuscarinic medications have left patients and physicians loo...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-010-0134-4
更新日期：2010-09-01 00:00:00
abstract：:Most children born with spina bifida, the most common disabling congenital abnormality, have normal renal function. If left untreated, more than half of these children will have serious renal deterioration by age 5. This deterioration is secondary to hostile neurogenic changes of the bladder. Renal development should ...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-008-0027-y
更新日期：2008-03-01 00:00:00
abstract：PURPOSE OF REVIEW:This review provides a critical literature overview of the risks and benefits of transplantectomy in patients with a failed allograft. Additionally, it offers a summary of related problems, primarily alloantibody sensitization in the event of nephrectomy and immunosuppression weaning. RECENT FINDINGS...
journal_title：Current urology reports
pub_type： 杂志文章
doi：10.1007/s11934-020-0957-6
更新日期：2020-01-18 00:00:00
abstract：:Adrenal cortical carcinoma is a relatively uncommon malignancy that represents a significant clinical challenge for the development of optimal treatment strategies. Historically, successful treatment has relied upon rapid identification of the lesion, accurate staging with diagnostic imaging, and complete surgical ext...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-007-0024-6
更新日期：2007-01-01 00:00:00
abstract：:The lack of reliable imaging tools in detecting prostate cancer makes a random biopsy still the standard of care to detect prostate cancer. To reduce the number of cores during a biopsy and therefore the risk of biopsy-related complications, an imaging tool which provides reliable guided biopsies is required. Transrec...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-013-0392-z
更新日期：2014-03-01 00:00:00
abstract：:Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a prevalent disease for which there is no standardized therapy. Traditional treatments have included antibiotics, α-blockers, and anti-inflammatories, but those have not proven to be efficacious therapies through many clinical trials. Alternative therapies,...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-011-0188-y
更新日期：2011-08-01 00:00:00
abstract：:Laparoscopic radical nephrectomy can be efficaciously performed by either the transperitoneal or the retroperitoneal laparoscopic approach. The primary indication for selecting one approach over another has historically depended on the individual surgeon's experience and training. With either technique, laparoscopy ad...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-002-0030-7
更新日期：2002-04-01 00:00:00
abstract：:To decrease side effects observed after high-intensity focused ultrasound (HIFU) treatment for localized prostate cancer and to re-establish normal micturition in a patient population that often presents with concomitant prostate enlargement, the impact of a combined transurethral resection of the prostate (TURP) and ...
journal_title：Current urology reports
pub_type： 临床试验,杂志文章
doi：10.1007/s11934-003-0077-0
更新日期：2003-06-01 00:00:00
abstract：:The increased detection of incidental renal masses has introduced new challenges into the management of patients with newly discovered renal masses. Much interest has been focused on the diagnostic accuracy and the prognostic ability of imaging studies. These studies have elucidated trends that can guide management bu...
journal_title：Current urology reports
pub_type： 杂志文章
doi：10.1007/s11934-009-0004-0
更新日期：2009-01-01 00:00:00
abstract：:Several minimally invasive approaches to treatment of ureteropelvic junction obstruction are now in the urologist's armamentarium. This review provides in-depth analysis of endopyelotomy, endopyeloplasty, and laparoscopic pyeloplasty and suggests a treatment algorithm for proper patient selection to improve efficacy a...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-007-0064-y
更新日期：2007-03-01 00:00:00
abstract：:Global improvements in water quality, management of infectious diseases, and other medical therapeutics have resulted in a growing population of healthy aging men. One obligate anatomic consequence of aging for these men is the development of benign prostatic hyperplasia (BPH) with secondary bladder outlet obstruction...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-014-0403-8
更新日期：2014-05-01 00:00:00
abstract：PURPOSE OF REVIEW:The goal of this paper was to review the novel treatment modality of high-intensity transurethral directional ultrasound for prostate cancer. RECENT FINDINGS:Prostate cancer is a heterogeneous disease with some patients electing for active surveillance and focal therapies instead of definitive treatm...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-020-01020-y
更新日期：2021-01-06 00:00:00
abstract：:The most important change in urology during the past decade was the development of minimally invasive surgery, particularly laparoscopy. However, the main drawback of laparoscopy is a steep learning curve, which results from the significant changes in the surgical environment. Although laparoscopy can provide importan...
journal_title：Current urology reports
pub_type： 杂志文章
doi：10.1007/s11934-003-0040-0
更新日期：2003-04-01 00:00:00
abstract：:Health information technology (HIT) is expected to transform the delivery of health care in the United States, but implementation and adoption vary widely across settings, specialties, and geographies. Significant barriers to high-level adoption persist despite federal incentives to hospitals and health-care providers...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-013-0356-3
更新日期：2013-12-01 00:00:00
abstract：:Overactive bladder (OAB) affects millions of people in the United States, and as the population ages, the prevalence of OAB will invariably increase. Conventional therapy for OAB includes behavioral modification and anticholinergic medication. OAB treatment comes with significant economic impact. With anticholinergic ...
journal_title：Current urology reports
pub_type： 杂志文章
doi：10.1007/s11934-009-0054-3
更新日期：2009-09-01 00:00:00
abstract：PURPOSE OF REVIEW:Patient-reported outcome measures (PROMs) are tools that are widely used by clinicians and researchers across different medical specialties. In this review, we examine the use of PROMs in the evaluation of female pelvic floor disorders (PFD). RECENT FINDINGS:PROM development in the assessment of urin...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-019-0888-2
更新日期：2019-03-27 00:00:00
abstract：:Focal therapy for prostate cancer has emerged an interesting concept as a less morbid option for the treatment of localized low-risk disease. Despite the growing interest in focal therapy, this approach has not yet gained sufficient popularity nor provided enough data to be discussed outside the experimental applicati...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-010-0100-1
更新日期：2010-05-01 00:00:00
abstract：:Impotence is often accompanied by loss of phallic length. To enhance penile prosthesis surgery, it is possible to perform simple adjuvant procedures that will increase perceived or true length. This article presents an overview of these techniques, which may be categorized as involving removal or fixation of tissue ab...
journal_title：Current urology reports
pub_type： 杂志文章
doi：10.1007/s11934-009-0075-y
更新日期：2009-11-01 00:00:00
abstract：PURPOSE OF REVIEW:From health systems to individuals, nephrolithiasis is economically burdensome. The aim of the current paper is to characterize the financial burden of disease associated with nephrolithiasis with an emphasis on investigating treatment modality economic efficiency. RECENT FINDINGS:For small volume pr...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-020-00971-6
更新日期：2020-03-31 00:00:00
abstract：PURPOSE OF REVIEW:Male urethral stricture disease is characterized by the formation of scar tissue within the urethra resulting in lower urinary tract symptoms, infection, and potentially kidney dysfunction. There is significant variability in clinical practice for the treatment of urethral stricture. We sought to summ...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-018-0771-6
更新日期：2018-02-26 00:00:00
abstract：PURPOSE OF REVIEW:Amid the opioid crisis, postoperative pain management is a major challenge for practitioners. Recent pain management guidelines emphasize the importance of using regional anesthesia as part of opioid-sparing multimodal analgesia. This report aims to review recent evidence regarding the utilization of ...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-019-0883-7
更新日期：2019-03-23 00:00:00
abstract：:Surgical techniques to repair hypospadias have undergone remarkable advances in recent years with the development and widespread use of dorsal urethral plate incision to facilitate urethroplasty. Clinical studies of the technique have shown excellent cosmesis and low complication rates for dorsal plate incision (DPI) ...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-001-0008-x
更新日期：2001-04-01 00:00:00
abstract：PURPOSE OF REVIEW:For many diseases that place a large burden on our health care system, men often have worse health outcomes than women. As the largest single provider of health care to men in the USA, the Veterans Health Administration (VA) has the potential to serve as leader in the delivery of improved men's health...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-017-0733-4
更新日期：2017-09-18 00:00:00
abstract：:DNA microarray technology provides a means to examine large numbers of molecular changes related to a biological process in a high throughput manner. This review discusses plausible utilities of this technology in prostate cancer research, including definition of prostate cancer predisposition, global profiling of gen...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-002-0011-x
更新日期：2002-02-01 00:00:00
abstract：:Author Siamak Daneshmand would like to note that this article published in Current Urology Reports inadvertently did not disclose financial information that could possibly be a conflict of interest. ...
journal_title：Current urology reports
pub_type： 杂志文章,已发布勘误
doi：10.1007/s11934-019-0890-8
更新日期：2019-04-05 00:00:00
abstract：:There is substantial variability in the extent of the node dissection performed during radical cystectomy for bladder cancer. Here, we review the diagnostic assessment of lymph node metastasis and the prognostic and therapeutic benefit for pelvic node dissection for bladder cancer. A review of the applicable urologic ...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-012-0235-3
更新日期：2012-04-01 00:00:00
abstract：:Patients diagnosed with prostate cancer who elect to pursue active treatment of their disease must choose among the many available treatment alternatives. Several treatment options now exist for similar-stage disease (clinical T1-3N0M0), including radical prostatectomy, external beam radiation, prostate brachytherapy ...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-000-0034-0
更新日期：2000-05-01 00:00:00
