Characterizing Indeterminate Renal Masses with Molecular Imaging: the Role of 99mTc-MIBI SPECT/CT.

Abstract:

PURPOSE OF REVIEW:The majority of enhancing renal masses cannot be characterized through imaging as malignant or benign; however, such characterization could save patients from unnecessary surgery and/or biopsy and associated morbidity. Herein, we review the recent literature on the emerging use of 99mTc-MIBI SPECT/CT in preoperative differentiation of enhancing renal masses. RECENT FINDINGS:Recent reports have shown that 99mTc-MIBI SPECT/CT imaging can differentiate mitochondrial-rich, benign, or indolent renal masses from renal cell carcinoma. These studies demonstrate good correlation between a positive 99mTc-MIBI SPECT/CT scan and a pathologically proven diagnosis of renal oncocytoma and hybrid oncocytic/chromophobe tumor. In addition, there is excellent correlation between a negative scan and a diagnosis of clear cell subtype of renal cell carcinoma. Preoperative 99mTc-MIBI SPECT/CT offers a non-invasive method for differentiating renal lesions with low aggressiveness from other RCCs, in particular, clear cell renal cell carcinoma.

journal_name

Curr Urol Rep

journal_title

Current urology reports

authors

Reynolds AM,Porter KK

doi

10.1007/s11934-017-0737-0

subject

Has Abstract

pub_date

2017-09-12 00:00:00

pages

86

issue

11

eissn

1527-2737

issn

1534-6285

pii

10.1007/s11934-017-0737-0

journal_volume

18

pub_type

杂志文章,评审
  • Expectant Management of Low-Risk Bladder Cancer.

    abstract::Patients with one or more low-grade bladder tumors of the urinary bladder will often develop a subsequent tumor but these so called "recurrences" are almost always of similar grade and rarely invade beyond the basement membrane. Therefore, the clinician should try to minimize the morbidity associated with treating the...

    journal_title:Current urology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11934-015-0555-1

    authors: Smith ZL,Soloway MS

    更新日期:2015-12-01 00:00:00

  • The effect of 15-lipoxygenase-1 expression on cancer cells.

    abstract::Lipoxygenases oxidatively metabolize polyunsaturated fatty acids to a rich spectrum of biologically active products. One enzyme of the lipoxygenase family, Arachidonate 15-lipoxygenase-1 (arachidonate:oxygen 15-oxidoreductase, EC 1.13.11.33), is implicated in several forms of epithelial cell cancers, and provides a ra...

    journal_title:Current urology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11934-002-0066-8

    authors: Kelavkar U,Glasgow W,Eling TE

    更新日期:2002-06-01 00:00:00

  • Phalloplasty and penile implant surgery.

    abstract::Impotence is often accompanied by loss of phallic length. To enhance penile prosthesis surgery, it is possible to perform simple adjuvant procedures that will increase perceived or true length. This article presents an overview of these techniques, which may be categorized as involving removal or fixation of tissue ab...

    journal_title:Current urology reports

    pub_type: 杂志文章

    doi:10.1007/s11934-009-0075-y

    authors: Caso JR,Myers MD,Wiegand L,Rodriguez A,Hann S,Carrion R

    更新日期:2009-11-01 00:00:00

  • Diagnosis and management of adrenal cortical carcinoma.

    abstract::Adrenal cortical carcinoma is a relatively uncommon malignancy that represents a significant clinical challenge for the development of optimal treatment strategies. Historically, successful treatment has relied upon rapid identification of the lesion, accurate staging with diagnostic imaging, and complete surgical ext...

    journal_title:Current urology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11934-007-0024-6

    authors: Fulmer BR

    更新日期:2007-01-01 00:00:00

  • Management of Vaginal Mesh Exposures Following Female Pelvic Reconstructive Surgery.

    abstract:PURPOSE OF REVIEW:To discuss considerations and current evidence for the diagnosis and management of vaginal mesh exposures following female mesh-augmented anti-incontinence and pelvic organ prolapse surgery. RECENT FINDINGS:Since the introduction of mesh into female pelvic surgery, various applications have been repo...

    journal_title:Current urology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11934-020-01002-0

    authors: Kisby CK,Linder BJ

    更新日期:2020-10-30 00:00:00

  • Pathological Bases and Clinical Impact of Intratumor Heterogeneity in Clear Cell Renal Cell Carcinoma.

    abstract:PURPOSE OF REVIEW:Intratumor heterogeneity is an inherent event in tumor development that is receiving much attention in the last years since it is responsible for most failures of current targeted therapies. The purpose of this review is to offer clinicians an updated insight of the multiple manifestations of a comple...

    journal_title:Current urology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11934-018-0754-7

    authors: López JI,Angulo JC

    更新日期:2018-01-27 00:00:00

  • Radical Prostatectomy for High-risk Localized or Node-Positive Prostate Cancer: Removing the Primary.

    abstract:PURPOSE OF REVIEW:We reviewed the literature to determine what role, if any, radical prostatectomy should play in the treatment of high-risk and/or node-positive prostate cancer. RECENT FINDINGS:The AUA, NCCN, and EAU all include radical prostatectomy as a treatment option for high-risk prostate cancer based on eviden...

    journal_title:Current urology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11934-017-0703-x

    authors: Matulay JT,DeCastro GJ

    更新日期:2017-07-01 00:00:00

  • Lymphadenectomy with robotic cystectomy.

    abstract::It is now established that an experienced, dedicated robotic surgeon can perform a high quality extended template pelvic lymph node dissection at the time of robot-assisted radical cystectomy. The evidence for this conclusion can be seen in comparing absolute lymph node counts, percent positive lymph nodes, and oncolo...

    journal_title:Current urology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11934-012-0288-3

    authors: Davis JW,Kamat AM

    更新日期:2013-02-01 00:00:00

  • Prostate-specific antigen and prostate-specific antigen derivatives as predictors of benign prostatic hyperplasia progression.

    abstract::Benign prostatic hyperplasia (BPH) is the most common urologic affliction in aging men, leading to adverse clinical outcomes in a significant proportion of the population. Serum prostate-specific antigen (PSA) has been established as a marker for prostate cancer for the past two decades but more recently has been reco...

    journal_title:Current urology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11934-007-0072-y

    authors: Levitt JM,Slawin KM

    更新日期:2007-07-01 00:00:00

  • Laparoscopic partial nephrectomy: technique and outcomes.

    abstract::Laparoscopic partial nephrectomy (LPN) was first described in 1992. Its increased use in recent years is a product of overall trends in surgery to minimize operative morbidity, as well as the downward stage migration of renal tumors detected incidentally through widespread medical imaging. Today the indications for LP...

    journal_title:Current urology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11934-009-0083-y

    authors: Berkman DS,Taneja SS

    更新日期:2010-02-01 00:00:00

  • Nocturnal Enuresis in the Adult.

    abstract:PURPOSE OF REVIEW:The goal of this paper is to describe the pathophysiology of adult nocturnal enuresis and develop a generalized approach for evaluation and treatment. RECENT FINDINGS:Although nocturnal enuresis (NE) impacts a significant proportion of the adult population, research on this topic remains lacking. In ...

    journal_title:Current urology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11934-020-00983-2

    authors: Katz EG,MacLachlan LS

    更新日期:2020-06-06 00:00:00

  • Does the prostatic vascular system contribute to the development of benign prostatic hyperplasia?

    abstract::Benign prostatic hyperplasia (BPH) is a disease condition characterized by abnormal prostate growth in conjunction with distinct lower urinary tract symptoms. This paper considers the extent to which the prostatic vascular system contributes to normal prostate growth control as well as whether abnormal blood flow patt...

    journal_title:Current urology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11934-002-0051-2

    authors: Ghafar MA,Puchner PJ,Anastasiadis AG,Cabelin MA,Buttyan R

    更新日期:2002-08-01 00:00:00

  • Pelvic ultrasound evaluation for benign prostatic hyperplasia: prediction of obstruction.

    abstract::Global improvements in water quality, management of infectious diseases, and other medical therapeutics have resulted in a growing population of healthy aging men. One obligate anatomic consequence of aging for these men is the development of benign prostatic hyperplasia (BPH) with secondary bladder outlet obstruction...

    journal_title:Current urology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11934-014-0403-8

    authors: Rukstalis DB

    更新日期:2014-05-01 00:00:00

  • High-Risk Non-Muscle-Invasive Bladder Cancer-Therapy Options During Intravesical BCG Shortage.

    abstract::Bladder cancer is the second commonest urinary tract malignancy with 70-80 % being non-muscle invasive (NMIBC) at diagnosis. Patients with high-risk NMIBC (T1/Tis, with high grade/G3, or CIS) represent a challenging group as they are at greater risk of recurrence and progression. Intravesical Bacilli Calmette-Guerin (...

    journal_title:Current urology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11934-016-0625-z

    authors: Veeratterapillay R,Heer R,Johnson MI,Persad R,Bach C

    更新日期:2016-09-01 00:00:00

  • Watchful waiting for small renal masses.

    abstract::Small renal masses (SRMs; < 4 cm in diameter) account for most renal tumors treated today. Incidental early detection of SRMs by abdominal imaging results in favorable grade and stage migration to renal cell carcinoma, and also increases detection of benign renal tumors. As a result, most SRMs manifest indolent biolog...

    journal_title:Current urology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11934-008-0006-3

    authors: Mattar K,Jewett MA

    更新日期:2008-01-01 00:00:00

  • Female sexual dysfunction following vaginal surgery: myth or reality?

    abstract::This article reviews the mechanisms by which vaginal surgery affects female sexual function and related pathophysiology to potential causes. The anatomy, neurovascular supply of the clitoris and introitus, and intrapelvic nerve supply are discussed as they apply to vaginal surgery. Methods to avoid neurovascular damag...

    journal_title:Current urology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11934-004-0091-x

    authors: Tunuguntla HS,Gousse AE

    更新日期:2004-10-01 00:00:00

  • Management of Pelvic Organ Prolapse After Radical Cystectomy.

    abstract:PURPOSE OF REVIEW:This article explores the anatomy, management options, and outcomes of pelvic organ prolapse with a female cystectomy patient. RECENT FINDINGS:There is a lack of data on surgical management outcomes for prolapse following radical cystectomy. However, most case series from tertiary referral centers sh...

    journal_title:Current urology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11934-019-0941-1

    authors: Lee D,Zimmern P

    更新日期:2019-10-15 00:00:00

  • Inflammation and prostate cancer: a focus on infections.

    abstract::Despite accumulating evidence that inflammation may affect the development of prostate cancer, responsible causes of intraprostatic inflammation remain elusive. This review presents epidemiologic literature on infections, particularly sexually transmitted and other ascending urogenital infections, as possible causes o...

    journal_title:Current urology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11934-008-0042-z

    authors: Sutcliffe S,Platz EA

    更新日期:2008-05-01 00:00:00

  • Urothelial effects of oral agents for overactive bladder.

    abstract::The cholinergic system of the bladder includes muscarinic receptors distributed to detrusor myocytes and structures within mucosa including bladder afferent (sensory) nerves. The receptors have been shown to be involved in afferent signaling from the bladder, but it has not been established to what extent effects on t...

    journal_title:Current urology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11934-008-0079-z

    authors: Andersson KE,Fullhase C,Soler R

    更新日期:2008-11-01 00:00:00

  • The Emergence of Kidney Stone Disease During Childhood-Impact on Adults.

    abstract:PURPOSE OF REVIEW:The goal of this chapter is to review the recent epidemiologic trends of kidney stone disease and discuss the impact of the increasing incidence of nephrolithiasis among children on adults with respect to extra-renal manifestations, surgical management, and secondary prevention. RECENT FINDINGS:Among...

    journal_title:Current urology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11934-017-0691-x

    authors: Bonzo JR,Tasian GE

    更新日期:2017-06-01 00:00:00

  • Health information technology in urologic care: current status and implications for quality of care.

    abstract::Health information technology (HIT) is expected to transform the delivery of health care in the United States, but implementation and adoption vary widely across settings, specialties, and geographies. Significant barriers to high-level adoption persist despite federal incentives to hospitals and health-care providers...

    journal_title:Current urology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11934-013-0356-3

    authors: Dowling RA

    更新日期:2013-12-01 00:00:00

  • The status of high-intensity focused ultrasound in the treatment of localized prostate cancer and the impact of a combined resection.

    abstract::To decrease side effects observed after high-intensity focused ultrasound (HIFU) treatment for localized prostate cancer and to re-establish normal micturition in a patient population that often presents with concomitant prostate enlargement, the impact of a combined transurethral resection of the prostate (TURP) and ...

    journal_title:Current urology reports

    pub_type: 临床试验,杂志文章

    doi:10.1007/s11934-003-0077-0

    authors: Chaussy C,Thüroff S

    更新日期:2003-06-01 00:00:00

  • Impact of alpha blockers, 5-alpha reductase inhibitors and combination therapy on sexual function.

    abstract::Medical treatments for lower urinary tract symptoms due to benign prostatic hyperplasia are frequently associated with changes in sexual function. While these medications are generally well-tolerated and have both reduced and delayed more invasive surgical options, the ramifications of long-term chronic use are largel...

    journal_title:Current urology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11934-014-0441-2

    authors: Welliver C,Butcher M,Potini Y,McVary KT

    更新日期:2014-10-01 00:00:00

  • DNA microarrays in prostate cancer.

    abstract::DNA microarray technology provides a means to examine large numbers of molecular changes related to a biological process in a high throughput manner. This review discusses plausible utilities of this technology in prostate cancer research, including definition of prostate cancer predisposition, global profiling of gen...

    journal_title:Current urology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11934-002-0011-x

    authors: Ho SM,Lau KM

    更新日期:2002-02-01 00:00:00

  • Conservative strategies for the treatment of stress urinary incontinence.

    abstract::The conservative treatment of stress urinary incontinence for women has many facets. Each intervention may have value and patients may benefit from simple, reversible recommendations and techniques versus invasive surgery. Starting with a thorough history, lifestyle modifications may lead to decreased incontinence. De...

    journal_title:Current urology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11934-005-0056-8

    authors: Dwyer NT,Kreder KJ

    更新日期:2005-09-01 00:00:00

  • Conservative management options for Peyronie's disease.

    abstract::Peyronie's disease is an acquired condition that presents clinically with a palpable induration, a distinct plaque, or a curvature of the erect penis. At times, the erections are painful. Erectile dysfunction (ED) often is associated with Peyronie's disease. The current era of phosphodiesterase therapy for the treatme...

    journal_title:Current urology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11934-005-0041-2

    authors: Jack GS,Gonzalez-Cadavid N,Rajfer J

    更新日期:2005-11-01 00:00:00

  • Evaluation and management of outlet obstruction in women without anatomical abnormalities on physical exam or cystoscopy.

    abstract::Bladder outlet obstruction (BOO) in women can be either anatomic or functional. Anatomic causes for BOO are often readily apparent by history and physical exam. On the other hand, causes for functional obstruction, including dysfunctional voiding, primary bladder neck obstruction, and detrusor-external sphincter dyssy...

    journal_title:Current urology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11934-012-0267-8

    authors: Hickling D,Aponte M,Nitti V

    更新日期:2012-10-01 00:00:00

  • An update on phthalates and male reproductive development and function.

    abstract::Phthalates are part of a class of high-volume industrial chemicals used ubiquitously in health care as well as household products. Biomarker studies have confirmed the widespread presence of these chemicals in both humans and animals. As a class, phthalates have been implicated in diseases and birth anomalies of the g...

    journal_title:Current urology reports

    pub_type: 杂志文章

    doi:10.1007/s11934-012-0261-1

    authors: Grady R,Sathyanarayana S

    更新日期:2012-08-01 00:00:00

  • Biomarkers for the detection and prognosis of prostate cancer.

    abstract::Recent studies have cast doubt on the reliability of serum total prostate-specific antigen as a biomarker for the detection and prognosis of prostate cancer. Biomarkers that can identify those men at risk for clinically significant prostate cancer are desperately needed. The search for biomarkers that may improve the ...

    journal_title:Current urology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11934-005-0004-7

    authors: Hernandez J,Canby-Hagino E,Thompson IM

    更新日期:2005-05-01 00:00:00

  • Adjuvant methods to improve results of local bladder irrigations by chemotherapy for NMIBC.

    abstract::Non-muscle-invasive bladder cancer is characterized by frequent recurrences requiring repeated transurethral resections and carries a risk of progression to muscle-invasive disease. The routinely used, passive diffusion irrigation of the bladder with mitomycin C has achieved limited success in avoiding these events. W...

    journal_title:Current urology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11934-012-0302-9

    authors: Freifeld Y,Dekel Y,Stein A

    更新日期:2013-04-01 00:00:00