Abstract：
:DNA microarray technology provides a means to examine large numbers of molecular changes related to a biological process in a high throughput manner. This review discusses plausible utilities of this technology in prostate cancer research, including definition of prostate cancer predisposition, global profiling of gene expression patterns associated with cancer initiation and progression, identification of new diagnostic and prognostic markers, and discovery of novel patient classification schemes. The technology, at present, has only been explored in a limited fashion in prostate cancer research. Some hurdles to be overcome are the high cost of the technology, insufficient sample size and repeated experiments, and the inadequate use of bioinformatics. With the completion of the Human Genome Project and the advance of several highly complementary technologies, such as laser capture microdissection, unbiased RNA amplification, customized functional arrays (eg, single-nucleotide polymorphism chips), and amenable bioinformatics software, this technology will become widely used by investigators in the field. The large amount of novel, unbiased hypotheses and insights generated by this technology is expected to have a significant impact on the diagnosis, treatment, and prevention of prostate cancer. Finally, this review emphasizes existing, but currently underutilized, data-mining tools, such as multivariate statistical analyses, neural networking, and machine learning techniques, to stimulate wider usage.
journal_name
Curr Urol Repjournal_title
Current urology reportsauthors
Ho SM,Lau KMdoi
10.1007/s11934-002-0011-xkeywords:
subject
Has Abstractpub_date
2002-02-01 00:00:00pages
53-60issue
1eissn
1527-2737issn
1534-6285journal_volume
3pub_type
杂志文章,评审abstract：PURPOSE OF REVIEW:It has been firmly established that hexaminolevulinate-assisted blue light cystoscopy (HAL-BLC) reduces cancer recurrence rates. This review explores the impact of HAL-BLC on other meaningful outcomes in patients with bladder cancer, including disease progression, and earlier detection of disease at t...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-020-0966-5
更新日期：2020-04-04 00:00:00
abstract：PURPOSE OF REVIEW:Recurrent urinary tract infections are a common condition that can impact patients' quality of life. The purpose of this review is to summarize and analyze the literature regarding the distress that these infections can cause to patients and provide guidance to clinicians on how to improve care of the...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-018-0849-1
更新日期：2018-10-18 00:00:00
abstract：:Because the number of patients requiring oral anticoagulation (OA) is steadily growing, more and more patients requiring surgical treatment of benign prostatic hyperplasia (BPH) are on OA. Laser treatment of BPH was said to offer a higher quality of hemostasis than transurethral resection of the prostate (TURP). Thus,...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-010-0115-7
更新日期：2010-07-01 00:00:00
abstract：:Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is the most common category of clinical prostatitis. The etiologic factors of CP/CPPS still remain unknown, and standard therapies often fail to achieve sustainable amelioration of symptoms; therefore, various treatment therapies have been approached. Recently...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-011-0186-0
更新日期：2011-08-01 00:00:00
abstract：PURPOSE OF REVIEW:From health systems to individuals, nephrolithiasis is economically burdensome. The aim of the current paper is to characterize the financial burden of disease associated with nephrolithiasis with an emphasis on investigating treatment modality economic efficiency. RECENT FINDINGS:For small volume pr...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-020-00971-6
更新日期：2020-03-31 00:00:00
abstract：:Benign prostatic hyperplasia (BPH) is the most common urologic affliction in aging men, leading to adverse clinical outcomes in a significant proportion of the population. Serum prostate-specific antigen (PSA) has been established as a marker for prostate cancer for the past two decades but more recently has been reco...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-007-0072-y
更新日期：2007-07-01 00:00:00
abstract：PURPOSE OF REVIEW:The symptoms of lower urinary tract dysfunction (LUTD) including urinary incontinence, frequency, and urgency are among the most common reasons children are referred to pediatric urologists. Despite this, the workup for LUTD is often time consuming and a source of frustration for patients, parents, an...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-018-0784-1
更新日期：2018-04-06 00:00:00
abstract：PURPOSE OF REVIEW:The majority of enhancing renal masses cannot be characterized through imaging as malignant or benign; however, such characterization could save patients from unnecessary surgery and/or biopsy and associated morbidity. Herein, we review the recent literature on the emerging use of 99mTc-MIBI SPECT/CT ...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-017-0737-0
更新日期：2017-09-12 00:00:00
abstract：:Adolescents with varicoceles represent a large and heterogeneous group. This patient population has rapidly changing hormonal levels and may present at different stages of physical and pubertal development. At the same time, the adolescent varicocele is becoming a more widely appreciated and diagnosed entity with an e...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-009-0026-7
更新日期：2009-03-01 00:00:00
abstract：:As bladder reconstruction strategies evolve, a feasible and safe source of transplantable urothelium becomes a major consideration for patients with advanced bladder disease, particularly cancer. Pluripotent stem cells, such as embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), are attractive cand...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-014-0466-6
更新日期：2015-01-01 00:00:00
abstract：PURPOSE OF REVIEW:Inflatable penile prosthesis (IPP) is a treatment for erectile dysfunction. IPPs have undergone improvements; however, post-surgical infections still occur. Furthermore, the type of pathogens infecting the implants has changed recently from Gram-positive to Gram-negative bacteria and fungi due to adva...
journal_title：Current urology reports
pub_type： 历史文章,杂志文章,评审
doi：10.1007/s11934-019-0874-8
更新日期：2019-01-30 00:00:00
abstract：PURPOSE OF THE REVIEW:This review targets the latest literature on bladder preservation therapy with emphasis on trimodal therapy (TMT), highlighting its role in the management of muscle invasive bladder cancer (MIBC) and outlining future directions in bladder preservation research. RECENT FINDINGS:TMT is the most pro...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-018-0859-z
更新日期：2018-11-03 00:00:00
abstract：:Laparoscopic adrenalectomy is considered to be the standard of care for the surgical excision of the adrenal gland. Since the initial report of laparoscopic adrenalectomy in 1992, it has evolved into a feasible and reproducible minimally invasive procedure for benign adrenal tumors. Transperitoneal and retroperitoneal...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-005-0070-x
更新日期：2005-02-01 00:00:00
abstract：:Phthalates are part of a class of high-volume industrial chemicals used ubiquitously in health care as well as household products. Biomarker studies have confirmed the widespread presence of these chemicals in both humans and animals. As a class, phthalates have been implicated in diseases and birth anomalies of the g...
journal_title：Current urology reports
pub_type： 杂志文章
doi：10.1007/s11934-012-0261-1
更新日期：2012-08-01 00:00:00
abstract：:The presence of a sufficient amount of androgens is essential for adequate sexual function in men. Gonadal hormones profoundly affect cognitive functions and, therefore, are fundamental in maintaining sexual desire. The earliest manifestation of hypogonadism is diminished libido. Furthermore, androgens also act periph...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-011-0202-4
更新日期：2011-12-01 00:00:00
abstract：PURPOSE OF REVIEW:This review provides a critical literature overview of the risks and benefits of transplantectomy in patients with a failed allograft. Additionally, it offers a summary of related problems, primarily alloantibody sensitization in the event of nephrectomy and immunosuppression weaning. RECENT FINDINGS...
journal_title：Current urology reports
pub_type： 杂志文章
doi：10.1007/s11934-020-0957-6
更新日期：2020-01-18 00:00:00
abstract：:Robot-assisted surgery has changed the landscape of surgery. Implementation of robotics into most surgical specialties has left many educators challenged to develop the tools necessary to train and credential surgeons. Advances in robot-assisted surgery have led to the development of simulators and tools to assess ski...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-015-0508-8
更新日期：2015-06-01 00:00:00
abstract：:Symptoms such as overactive bladder represent disorders of bladder control. Functional brain scanning by positron emission tomography and functional magnetic resonance imaging suggest that normal control is exerted by a network of regions in the emotional nervous system, including periaqueductal gray, thalamus, insula...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-004-0081-z
更新日期：2004-10-01 00:00:00
abstract：:Significant clinical and basic science advances in the field of sexual medicine have facilitated investigation of the link between endothelial dysfunction and erectile dysfunction. Most sexual medicine practitioners accept the premise that in aging men with risk factors such as increased waist circumference, diabetes,...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-007-0054-0
更新日期：2007-11-01 00:00:00
abstract：:Overactive bladder syndrome continues to be a significant burden for the general population. Current first-line medical therapy often includes antimuscarinic medications designed for overactive bladder. Poor efficacy and significant side effects of these antimuscarinic medications have left patients and physicians loo...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-010-0134-4
更新日期：2010-09-01 00:00:00
abstract：:Impotence is often accompanied by loss of phallic length. To enhance penile prosthesis surgery, it is possible to perform simple adjuvant procedures that will increase perceived or true length. This article presents an overview of these techniques, which may be categorized as involving removal or fixation of tissue ab...
journal_title：Current urology reports
pub_type： 杂志文章
doi：10.1007/s11934-009-0075-y
更新日期：2009-11-01 00:00:00
abstract：PURPOSE OF REVIEW:The goal of this chapter is to review the recent epidemiologic trends of kidney stone disease and discuss the impact of the increasing incidence of nephrolithiasis among children on adults with respect to extra-renal manifestations, surgical management, and secondary prevention. RECENT FINDINGS:Among...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-017-0691-x
更新日期：2017-06-01 00:00:00
abstract：:Significant progress has been made over the past 15 years regarding the development of bladder control and the evaluation and management of pediatric voiding dysfunction. Incontinence is a problem of significant social consequence that is commonly due to dysfunctional voiding (ie, discoordination between the detrusor ...
journal_title：Current urology reports
pub_type： 杂志文章
doi：10.1007/s11934-010-0099-3
更新日期：2010-03-01 00:00:00
abstract：:This article reviews the mechanisms by which vaginal surgery affects female sexual function and related pathophysiology to potential causes. The anatomy, neurovascular supply of the clitoris and introitus, and intrapelvic nerve supply are discussed as they apply to vaginal surgery. Methods to avoid neurovascular damag...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-004-0091-x
更新日期：2004-10-01 00:00:00
abstract：PURPOSE OF REVIEW:There are an estimated 33 million men and women with overactive bladder (OAB) in the USA. Despite the prevalence of OAB, it remains a frequently misdiagnosed condition. OAB has shared symptomatology with other common urologic conditions, namely recurrent urinary tract infections (UTIs). Here, we will ...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-018-0839-3
更新日期：2018-09-13 00:00:00
abstract：:Benign prostatic hyperplasia (BPH) is a common cause of lower urinary tract symptoms (LUTS) in men. Patients with BPH often present with a combination of obstructive and overactive bladder (OAB) symptoms. It is postulated that bladder outlet obstruction (BOO) from BPH results in concomitant OAB symptoms through ischem...
journal_title：Current urology reports
pub_type： 杂志文章
doi：10.1007/s11934-013-0363-4
更新日期：2013-12-01 00:00:00
abstract：:Partial nephrectomy has become an accepted treatment of cT1 renal masses as it provides improved long-term renal function compared to radical nephrectomy (Campbell et al. J Urol. 182:1271-9, 2009). Hilar clamping is utilized to help reduce bleeding and improve visibility during tumor resection. However, concern over r...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-016-0596-0
更新日期：2016-05-01 00:00:00
abstract：:Bulking therapy for stress urinary incontinence in women continues to evolve from the standpoint of material science. Several new materials have recently been subjected to clinical trials with the aim of assessing efficacy and safety of these agents for possible device registration. These new additions run the gamut o...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-006-0012-2
更新日期：2006-09-01 00:00:00
abstract：PURPOSE OF REVIEW:The classification of morphologically normal sperm has been progressively redefined. Concurrently, our understanding of the significance of sperm morphology in relation to male factor infertility has evolved. In this review, we will discuss the evolution of sperm morphology assessment and factors that...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-019-0911-7
更新日期：2019-06-15 00:00:00
abstract：:Erectile dysfunction (ED) is common after radical prostatectomy (RP). ED has a negative impact on health-related quality of life. Penile rehabilitation is defined as the use of any drug or device at or after RP to maximize erectile function recovery. The purpose of penile rehabilitation is the prevention of corpus cav...
journal_title：Current urology reports
pub_type： 杂志文章,评审
doi：10.1007/s11934-009-0037-4
更新日期：2009-05-01 00:00:00
