Abstract：
:The toxin delivery system described herein would allow for the selective killing of tumor cells overexpressing the epidermal growth factor receptor (EGFR). Tumor cells often overexpress EGFR, because it allows the cells to divide more quickly. Past delivery systems targeting this receptor have been ineffective due to a lack of specificity that results in harm to surrounding tissue and damage to organs such as the liver. The technique presented here is different, because it presents the possibility of delivering toxin only to the tumor area and almost exclusively to the tumor cells. Delivery is localized to the tumor tissue through the use of EGF conjugated magnetoliposomes. These are liposomes that have magnets imbedded in their bilayer, allowing for selective heating and release of a drug when the magnetoliposome is under an oscillating magnetic field. To create an additional level of specificity, the delivery system will consist of two EGF-bound components that must interact within the endosome of a cell for the toxin to be released. If a tumor cell overexpresses EGFR by 5-fold, then each of its endosomes will have 5 times more receptors than those of a normal cell. Therefore, the tumor cell's endosome has a 5 times greater chance of containing one EGF-bound component and a 25 times greater chance of containing both components. Since both components are necessary for toxin release, the tumor cells will receive 25 times more toxin than the normal cells. Theoretically, it is possible to produce a three or four component system that would deliver 125 or 625 times more toxin to the tumor cells.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Kullberg M,Mann K,Owens JLdoi
10.1016/j.mehy.2004.07.033keywords:
subject
Has Abstractpub_date
2005-01-01 00:00:00pages
468-70issue
3eissn
0306-9877issn
1532-2777pii
S0306-9877(04)00472-4journal_volume
64pub_type
杂志文章abstract：:Circumstantial evidence links neuropathological changes in postencephalitic Parkinson's disease and amyotrophic lateral sclerosis on Guam to the 1918 influenza pandemic. Postencephalitic Parkinson's disease and amyotrophic lateral sclerosis have neuronal neurofibrillary tangles that anatomically correlate with clinica...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.2000.1224
更新日期：2002-03-01 00:00:00
abstract：:The favourable effects of eicosapentaenoic acid (EPA)- and doco-sahexaenoic acid (DHA)-rich diets (marine fish, fish oil) on several risk factors for cardiovascular disease are well established. The present survey describes possible new indications for diets supplemented with long-chain n-3 fatty acids. During a stand...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(91)90169-y
更新日期：1991-09-01 00:00:00
abstract：:I have previously assumed that stem tumour cells are 'para-embryonal cells' (PECs) poor or missing in major histocompatibility complex (MHC) antigens. PECs might induce adjoining differentiated hyperplastic cells to also express tumoral phenotype and properties, thus transforming them into 'differentiated para-embryon...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(98)90213-4
更新日期：1998-05-01 00:00:00
abstract：:COVID-19 (coronavirus disease 2019) pandemic due to infection with SARS-CoV-2 has led to the death of thousands of adults worldwide. It is now clear that the hyper-inflammatory response triggered by SARS-CoV-2 plays a major role in disease severity and lethality of the infection. Macrophages are innate immune cells th...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2020.110073
更新日期：2020-10-01 00:00:00
abstract：:Interferon-alpha (IFN) is widely used in the treatment of certain cancers and viral infections, including hepatitis C (HCV). Unfortunately, depression is a common side effect of IFN therapy, affecting approximately a third of HCV patients receiving IFN therapy. Studies have shown that selective serotonin reuptake inhi...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2005.01.026
更新日期：2005-01-01 00:00:00
abstract：:Recent studies suggest that blood-borne metabolites of gut microbiota, such as trimethylamine N-oxide (TMAO) are involved in the aetiology of cardiovascular diseases and may serve as markers of cardiovascular risk. To enter the bloodstream the microbiota-derived molecules need to pass the gut-blood barrier (GBB). The ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2016.11.012
更新日期：2017-01-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(02)00294-3
更新日期：2003-08-01 00:00:00
abstract：:Functional, excessive-possibly temporary-deficiencies of the trace element zinc can change immune functions prematurely from predominantly cellular Th1 responses to humoral Th2 responses. T helper (Th1) cells produce cytokines such as interleukin-2 (IL-2) and interferon gamma, thereby controlling viral infections and ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(97)90244-9
更新日期：1997-07-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(91)90284-6
更新日期：1991-08-01 00:00:00
abstract：:For American medical historiography, to borrow from Dickens, these are the best of times and the worst of times. These are the times when rigorous scholarship has been brought to bear on the field (with great improvement in the quality of research) and when medicine is disappearing from its own history. These are the ...
journal_title：Medical hypotheses
pub_type： 历史文章,杂志文章
doi：10.1016/0306-9877(92)90079-r
更新日期：1992-06-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2016.05.030
更新日期：2016-08-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2018.08.028
更新日期：2018-11-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(79)90072-0
更新日期：1979-08-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2019.109370
更新日期：2019-11-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2010.10.035
更新日期：2011-03-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(81)90124-9
更新日期：1981-11-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2018.04.024
更新日期：2018-07-01 00:00:00
abstract：:The per review system for the assessment of research proposals is widely respected by working scientists. Nevertheless two problems associated with the operation of this system by the US National Institutes of Health are identified. First the scientist has no control over which committee will review an application and...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(76)80019-9
更新日期：1976-01-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2009.10.013
更新日期：2010-03-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(77)90043-3
更新日期：1977-01-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2018.02.023
更新日期：2018-05-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.2001.1532
更新日期：2002-06-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：2020-02-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 信件
doi：10.1016/j.mehy.2020.110244
更新日期：2020-10-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(83)90009-9
更新日期：1983-04-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2015.08.025
更新日期：2015-12-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.2001.1511
更新日期：2002-02-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(96)90046-8
更新日期：1996-07-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2004.12.018
更新日期：2005-01-01 00:00:00
abstract：:This hypothesis clearly proposes the true and previously undiscovered cause of male homosexuality or bisexuality and in most cases the predictability in infancy of the development of this sexuality in adulthood. It is based on compelling new evidence which has accumulated over many years. The fetal and neonatal period...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2016.06.006
更新日期：2016-09-01 00:00:00
