Abstract:
:The therapeutic efficacy of thalidomide in erythema nodosum leprosum suggests that thalidomide might play a useful therapeutic role in other human immune-complex diseases. Thalidomide has shown anti-inflammatory or immunosuppressive actions in several animal models. Current evidence suggests that its rapid activity in ENL may result from suppression of neutrophil chemotaxis and phagocytosis. Scattered anecdotal clinical reports of apparent response to thalidomide in various autoimmune diseases are hardly conclusive, but underline the desirability of appropriate pilot trials of thalidomide in autoimmune diseases, particularly those in which immune complex deposition plays a prominent role. Provided that a contraindication in fertile women is strictly observed, thalidomide therapy appears to be quite safe.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Hendler SS,McCarty MFdoi
10.1016/0306-9877(83)90009-9subject
Has Abstractpub_date
1983-04-01 00:00:00pages
437-43issue
4eissn
0306-9877issn
1532-2777pii
0306-9877(83)90009-9journal_volume
10pub_type
杂志文章abstract::Pre-implantation genetic diagnosis (PGD) is a powerful clinical tool to identify embryos with or at risk of specific genetic diseases before implantation in utero after in vitro fertilization (IVF). PGD is performed on embryo biopsies that are obtained by aspiration of one or two cells from pre-implantation embryos at...
journal_title:Medical hypotheses
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pub_type: 杂志文章
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journal_title:Medical hypotheses
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journal_title:Medical hypotheses
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pub_type: 杂志文章
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更新日期:2015-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2011-08-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2012-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2010-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.mehy.2009.02.024
更新日期:2009-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0306-9877(92)90057-j
更新日期:1992-12-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2011.05.002
更新日期:2011-09-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.1998.0808
更新日期:2000-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2009.03.053
更新日期:2009-12-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2007.07.040
更新日期:2008-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.mehy.2012.06.004
更新日期:2012-09-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2018-08-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.1998.0756
更新日期:1999-10-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2004.03.040
更新日期:2004-01-01 00:00:00
abstract::The staggering number of publications featuring the use of stem cells has revolutionized regenerative medicine research. Preclinical studies indicate that allogeneic human mesenchymal stem cells (MSCs) may be useful for the treatment of several clinical disorders, including sepsis, acute renal failure, acute myocardia...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2011.01.010
更新日期:2011-04-01 00:00:00
abstract::Arthritis is inflammation in a joint often with joint damage, usually accompanied by pain, swelling and stiffness, resulting from infection, trauma, degenerative changes, metabolic disturbances, autoimmune or other causes. It occurs in various forms, including rheumatoid arthritis, osteoarthritis, bacterial arthritis ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2005.06.021
更新日期:2005-01-01 00:00:00
abstract::Immune competence is considered as a state of equilibrium between humoral and cellular immunity. This notion fits well with the functionally antagonistic cytokine profiles in cell groups of CD4(+)-helper cells as described by Mosmann and Coffman. The Th-1 cells release mainly IL-2, IL-12 and IFN gamma and thereby stim...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/s0306-9877(96)90130-9
更新日期:1996-06-01 00:00:00
abstract:BACKGROUND:Somatization is a multisomatoform disorder characterized by medically unexplained, functional or psychosomatic symptoms. Similar somatic symptoms are key components of depression and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). METHODS:This paper reviews the evidence that such symptoms are o...
journal_title:Medical hypotheses
pub_type: 杂志文章,评审
doi:10.1016/j.mehy.2012.02.023
更新日期:2012-06-01 00:00:00