Abstract:
:Several proteins that have substantially diverged during evolution retain similar three-dimensional structures and biological function inspite of poor sequence identity. The database on Genomic Distribution of protein structural domain Superfamilies (GenDiS) provides record for the distribution of 4001 protein domains organized as 1194 structural superfamilies across 18,997 genomes at various levels of hierarchy in taxonomy. GenDiS database provides a survey of protein domains enlisted in sequence databases employing a 3-fold sequence search approach. Lineage-specific literature is obtained from the taxonomy database for individual protein members to provide a platform for performing genomic and phyletic studies across organisms. The database documents residual properties and provides alignments for the various superfamily members in genomes, offering insights into the rational design of experiments and for the better understanding of a superfamily. GenDiS database can be accessed at http://www.ncbs.res.in/~faculty/mini/gendis/home.html.
journal_name
Nucleic Acids Resjournal_title
Nucleic acids researchauthors
Pugalenthi G,Bhaduri A,Sowdhamini Rdoi
10.1093/nar/gki087keywords:
subject
Has Abstractpub_date
2005-01-01 00:00:00pages
D252-5issue
Database issueeissn
0305-1048issn
1362-4962pii
33/suppl_1/D252journal_volume
33pub_type
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