Immunolocalisation of P2X and P2Y nucleotide receptors in the rat nasal mucosa.

Abstract:

:Purinoceptor subtypes were localised to various tissue types present within the nasal cavity of the rat, using immunohistochemical methods. P2X3 receptor immunoreactivity was localised in the primary olfactory neurones located both in the olfactory epithelium and vomeronasal organs (VNO) and also on subepithelial nerve fibres in the respiratory region. P2X5 receptor immunoreactivity was found in the squamous, respiratory and olfactory epithelial cells of the rat nasal mucosa. P2X7 receptor immunoreactivity was also expressed in epithelial cells and colocalised with caspase 9 (an apoptotic marker), suggesting an association with apoptosis and epithelial turnover. P2Y1 receptor immunoreactivity was found within the respiratory epithelium and submucosal glandular tissue. P2Y2 receptor immunoreactivity was localised to the mucus-secreting cells within the VNO. The possible functional roles of these receptors are discussed.

journal_name

Cell Tissue Res

journal_title

Cell and tissue research

authors

Gayle S,Burnstock G

doi

10.1007/s00441-004-0979-2

keywords:

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

27-36

issue

1

eissn

0302-766X

issn

1432-0878

journal_volume

319

pub_type

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