Abstract:
:The ultrastructural distribution of fibronectin immunoreactivity was investigated in the chicken embryo during late gastrulation. Sites of binding of anti-fibronectin antibodies were ascribed to the basal lamina and associated structures, and to the cell surface. The fibronectin-rich basal lamina was resolved into a lamina densa, which appears as a continuous, dense sheet, a lamina lucida, consisting of anchoring cords between lamina densa and epithelial cells, and a lamina intima, closely juxtaposed to the cell surface. Cell-surface labelling was also observed in mesoblast cells, and along the dorsal side of the deep-layer cells. The ventral side of the latter cells was poorly stained in the endophyllic crescent, except in coated pits, and more regularly stained at the level of definitive endoblast. Some structures associated with the basal lamina reacted intensely with anti-fibronectin antibodies. These are the interstitial bodies, which are aggregates of extracellular material, and a kind of fibril or tubule, embedded in a fibronectin matrix and mainly found in the endophyllic crescent. Some intracellular labelling was found in most deep-layer cells, in few epiblast cells, never in mesoblast cells. These results extend previous studies on the localization of fibronectin, and correlate its presence and surface topology with its postulated role in migration of mesoblast cells on the basal lamina which, chemically, constitutes an appropriate substrate.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Harrisson F,Vanroelen C,Vakaet Ldoi
10.1007/BF00217185subject
Has Abstractpub_date
1985-01-01 00:00:00pages
391-7issue
2eissn
0302-766Xissn
1432-0878journal_volume
241pub_type
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journal_title:Cell and tissue research
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