Abstract:
:When spores of the anaerobic bacterium Clostridium novyi-NT are systemically injected into animals, they germinate exclusively within the hypoxic regions of cancers. The germinated bacteria destroy adjacent tumor cells but spare a rim of well oxygenated tumor cells that subsequently expand. Surprisingly, we found that approximately 30% of mice treated with such spores were cured of their cancers despite the viable tumor rim initially remaining after spore germination. The mechanism underlying this effect was shown to be immune-mediated, because cured animals rejected a subsequent challenge of the same tumor. Similar effects were observed in rabbits with intrahepatic tumors. It was particularly notable that the induced immune response, when combined with the bacteriolytic effects of C. novyi-NT, could eradicate large established tumors.
journal_name
Proc Natl Acad Sci U S Aauthors
Agrawal N,Bettegowda C,Cheong I,Geschwind JF,Drake CG,Hipkiss EL,Tatsumi M,Dang LH,Diaz LA Jr,Pomper M,Abusedera M,Wahl RL,Kinzler KW,Zhou S,Huso DL,Vogelstein Bdoi
10.1073/pnas.0406242101keywords:
subject
Has Abstractpub_date
2004-10-19 00:00:00pages
15172-7issue
42eissn
0027-8424issn
1091-6490pii
0406242101journal_volume
101pub_type
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