Abstract:
:Mismatch repair (MMR) systems are central to maintaining genome stability in prokaryotes and eukaryotes. MMR proteins play a fundamental role in avoiding mutations, primarily by removing misincorporation errors that occur during DNA replication. MMR proteins also act during genetic recombination in steps that include repairing mismatches in heteroduplex DNA, modulating meiotic crossover control, removing 3' non-homologous tails during double-strand break repair, and preventing recombination between divergent sequences. In this review we will, first, discuss roles for MMR proteins in repairing mismatches that occur during recombination, particularly during meiosis. We will also explore how studying this process has helped to refine models of double-strand break repair, and particularly to our understanding of gene conversion gradients. Second, we will examine the role of MMR proteins in repressing homeologous recombination, i.e. recombination between divergent sequences. We will also compare the requirements for MMR proteins in preventing homeologous recombination to the requirements for these proteins in mismatch repair.
journal_name
Cytogenet Genome Resjournal_title
Cytogenetic and genome researchauthors
Surtees JA,Argueso JL,Alani Edoi
10.1159/000080593keywords:
subject
Has Abstractpub_date
2004-01-01 00:00:00pages
146-59issue
3-4eissn
1424-8581issn
1424-859Xpii
80593journal_volume
107pub_type
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