Abstract:
:Genetic strategies for the post-genomic sequence age will be designed to provide information about gene function in a myriad of physiological processes. Here an ENU mutagenesis program (http://reprogenomics.jax.org) is described that is generating a large resource of mutant mouse models of infertility; male and female mutants with defects in a wide range of reproductive processes are being recovered. Identification of the genes responsible for these defects, and the pathways in which these genes function, will advance the fields of reproduction research and medicine. Importantly, this program has potential to reveal novel human contraceptive targets.
journal_name
Cytogenet Genome Resjournal_title
Cytogenetic and genome researchauthors
Lessard C,Pendola JK,Hartford SA,Schimenti JC,Handel MA,Eppig JJdoi
10.1159/000078192keywords:
subject
Has Abstractpub_date
2004-01-01 00:00:00pages
222-7issue
2-4eissn
1424-8581issn
1424-859Xpii
78192journal_volume
105pub_type
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