Abstract:
OBJECTIVES:To investigate the effects of two different regimens of androgenic-anabolic steroid (AAS) administration on serum lipid and lipoproteins, and recovery of these variables after drug cessation, as indicators of the risk for cardiovascular disease in healthy male strength athletes. METHODS:In a non-blinded study (study 1) serum lipoproteins and lipids were assessed in 19 subjects who self administered AASs for eight or 14 weeks, and in 16 non-using volunteers. In a randomised double blind, placebo controlled design, the effects of intramuscular administration of nandrolone decanoate (200 mg/week) for eight weeks on the same variables in 16 bodybuilders were studied (study 2). Fasting serum concentrations of total cholesterol, triglycerides, HDL-cholesterol (HDL-C), HDL2-cholesterol (HDL2-C), HDL3-cholesterol (HDL3-C), apolipoprotein A1 (Apo-A1), apolipoprotein B (Apo-B), and lipoprotein (a) (Lp(a)) were determined. RESULTS:In study 1 AAS administration led to decreases in serum concentrations of HDL-C (from 1.08 (0.30) to 0.43 (0.22) mmol/l), HDL2-C (from 0.21 (0.18) to 0.05 (0.03) mmol/l), HDL3-C (from 0.87 (0.24) to 0.40 (0.20) mmol/l, and Apo-A1 (from 1.41 (0.27) to 0.71 (0.34) g/l), whereas Apo-B increased from 0.96 (0.13) to 1.32 (0.28) g/l. Serum Lp(a) declined from 189 (315) to 32 (63) U/l. Total cholesterol and triglycerides did not change significantly. Alterations after eight and 14 weeks of AAS administration were comparable. No changes occurred in the controls. Six weeks after AAS cessation, serum HDL-C, HDL2-C, Apo-A1, Apo-B, and Lp(a) had still not returned to baseline concentrations. Administration of AAS for 14 weeks was associated with slower recovery to pretreatment concentrations than administration for eight weeks. In study 2, nandrolone decanoate did not influence serum triglycerides, total cholesterol, HDL-C, HDL2-C, HDL3-C, Apo-A1, and Apo-B concentrations after four and eight weeks of intervention, nor six weeks after withdrawal. However, Lp(a) concentrations decreased significantly from 103 (68) to 65 (44) U/l in the nandrolone decanoate group, and in the placebo group a smaller reduction from 245 (245) to 201 (194) U/l was observed. Six weeks after the intervention period, Lp(a) concentrations had returned to baseline values in both groups. CONCLUSIONS:Self administration of several AASs simultaneously for eight or 14 weeks produces comparable profound unfavourable effects on lipids and lipoproteins, leading to an increased atherogenic lipid profile, despite a beneficial effect on Lp(a) concentration. The changes persist after AAS withdrawal, and normalisation depends on the duration of the drug abuse. Eight weeks of administration of nandrolone decanoate does not affect lipid and lipoprotein concentrations, although it may selectively reduce Lp(a) concentrations. The effect of this on atherogenesis remains to be established.
journal_name
Br J Sports Medjournal_title
British journal of sports medicineauthors
Hartgens F,Rietjens G,Keizer HA,Kuipers H,Wolffenbuttel BHdoi
10.1136/bjsm.2003.000199keywords:
subject
Has Abstractpub_date
2004-06-01 00:00:00pages
253-9issue
3eissn
0306-3674issn
1473-0480journal_volume
38pub_type
临床试验,杂志文章,随机对照试验abstract:BACKGROUND:Improved oxygen uptake improves soccer performance as regards distance covered, involvements with the ball, and number of sprints. Large improvements in oxygen uptake have been shown using interval running. A similar physiological load arising from interval running could be obtained using the soccer ball in ...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.2004.012526
更新日期:2005-05-01 00:00:00
abstract:OBJECTIVE:To determine physical activity levels during phase IV cardiac rehabilitation in 31 male myocardial infarction patients (median age 62, range 53-77 years). METHODS:Patients recorded daily physical activity over 16 weeks in a diary. Diaries were analysed for total general physical activity (TGPA), leisure time...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.2003.010983
更新日期:2005-03-01 00:00:00
abstract:BACKGROUND:There seems to be a discrepancy between the available heat stress guidelines and the actual risk of heat-related illness among professional beach volleyball players competing under hot and humid conditions. OBJECTIVE:To monitor heat stress and record cases of heat-related medical forfeits on the Swatch FIVB...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsports-2012-091102
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:Blood lactate concentration (BLC) can be used to monitor relative exercise intensity. The highest BLC representing an equilibrium between lactate production and elimination is termed maximal lactate steady state (MLSS). MLSS is used to discriminate qualitatively between continuous exercise, which is limited ...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.35.3.192
更新日期:2001-06-01 00:00:00
abstract::The purpose of this investigation was to compare the effectiveness of using ratings of perceived exertion (RPE) with heart rate in the monitoring of exercise intensity during aerobic dance instruction. Thirty-eight students who enrolled in aerobic dance classes used heart rate to monitor exercise intensity while 38 ad...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.26.2.132
更新日期:1992-06-01 00:00:00
abstract:BACKGROUND:It is unclear whether world class endurance athletes, in contrast with less well trained subjects, increase their haemoglobin mass on a regimen of living high and training low (LHTL). OBJECTIVE:To assess whether haemoglobin mass increases in world class athletes on LHTL and whether this increase is associat...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.2005.019729
更新日期:2006-02-01 00:00:00
abstract::Regular physical exercise reduces cardiovascular morbidity and mortality. A small proportion of athletes, however, are at increased risk of exercise-related sudden cardiac death (SCD) as a result of quiescent cardiac anomalies. The preventable nature of such deaths has prompted the medical and sporting governing bodie...
journal_title:British journal of sports medicine
pub_type: 杂志文章,评审
doi:10.1136/bjsm.2008.054874
更新日期:2009-09-01 00:00:00
abstract:OBJECTIVES:Physical inactivity has been associated with significant increases in disease morbidity and mortality. This study assessed the association between physical activity and (1) health resource use and (2) health resource use costs. DESIGN AND PARTICIPANTS:The responses from 24 281 respondents >65 years to the C...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.2008.057216
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND:Gymnasts practise many hours a week, and symptoms from injuries do not seem to stop them from continuing with practice. They may even compete with symptoms from injuries, which could increase the risk of reinjury, or of the occurrence of a more severe injury. OBJECTIVES:To investigate whether team gymnasts ...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.2002.001990
更新日期:2004-08-01 00:00:00
abstract::The purpose of this study was to formulate a simplistic method of assessing human structural dysplasia and to validate a classification system that would objectively categorize the type and extent of such dysplasia through the use of indices. Anthropometric measurements were taken from a sample of 222 male college stu...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.18.1.22
更新日期:1984-03-01 00:00:00
abstract::Reports on reproducibility of lactate markers usually considered only two trials. The authors assessed reproducibility of power output at seven markers in 11 fit subjects over at least six trials under tightly controlled conditions. Subjects undertook incremental exercises (50 W start, +50 W every 3 min to exhaustion)...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.2010.076380
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Concussion in sport typically recovers clinically within 10 days of injury. In some cases, however, symptoms may be prolonged or complications may develop. The objectives of the current paper are to review the literature regarding the difficult concussion and to provide recommendations for an approach to the...
journal_title:British journal of sports medicine
pub_type: 杂志文章,评审
doi:10.1136/bjsports-2013-092255
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:Athletic groin pain (AGP) is an encompassing term for the multitude of chronic conditions presenting as pain in the inguinal region. The purpose of this review was to compare the return to play rates (RTPrate) and return to play times (RTPtime) between surgical and rehabilitation interventions in the treatme...
journal_title:British journal of sports medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1136/bjsports-2014-093715
更新日期:2015-11-01 00:00:00
abstract:OBJECTIVES:To identify physical activity that is beneficial for the maintenance of bone strength with increasing age by examining the relation between bone mineral density (BMD) and chronic endurance training in men. BMD at the proximal femur, its subregions, and the lumbar spine, and serum testosterone were compared b...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.34.4.273
更新日期:2000-08-01 00:00:00
abstract::The second international consensus conference on the scapula was held in Lexington Kentucky. The purpose of the conference was to update, present and discuss the accumulated knowledge regarding scapular involvement in various shoulder injuries and highlight the clinical implications for the evaluation and treatment of...
journal_title:British journal of sports medicine
pub_type: 共识发展会议,杂志文章
doi:10.1136/bjsports-2013-092425
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND:No previous study on adult football involving several different countries has investigated the incidence and pattern of injuries at the highest club competitive level. OBJECTIVE:To investigate the risk exposure, risk of injury, and injury pattern of footballers involved in UEFA Champions League and internat...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.2004.014571
更新日期:2005-08-01 00:00:00
abstract::The central governor model has recently been proposed as a general model to explain the phenomenon of fatigue. It proposes that the subconscious brain regulates power output (pacing strategy) by modulating motor unit recruitment to preserve whole body homoeostasis and prevent catastrophic physiological failure such as...
journal_title:British journal of sports medicine
pub_type: 杂志文章,评审
doi:10.1136/bjsm.2005.023028
更新日期:2006-07-01 00:00:00
abstract:BACKGROUND:Research on injuries in racing drivers is limited. OBJECTIVE:To gain more information about such injuries. METHODS:Injuries recorded during and after races between 1996 and 2000 were investigated using the medical charts from the circuit medical centre at Fuji Speedway, which is one of the biggest circuits...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.2003.007674
更新日期:2004-10-01 00:00:00
abstract:OBJECTIVE:The introduction of shoulder pads has coincided with a rise in shoulder impact injuries in the game of rugby. In this study, the effect of shoulder pads on impact force attenuation was quantified. DESIGN:Four different commercially available shoulder pads were tested for material properties. Hard and soft ob...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.2008.047449
更新日期:2010-02-01 00:00:00
abstract::The question of whether altitude training can enhance subsequent sea-level performance has been well investigated over many decades. However, research on this topic has focused on athletes from individual or endurance sports, with scant number of studies on team-sport athletes. Questions that need to be answered inclu...
journal_title:British journal of sports medicine
pub_type: 杂志文章,评审
doi:10.1136/bjsports-2013-092764
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:Screening to prevent sudden cardiac death remains a contentious topic in sport and exercise medicine. The aim of this study was to assess whether the use of a standardised criteria tool improves the accuracy of ECG interpretation by physicians screening athletes. METHODS:Design: Randomised control trial. St...
journal_title:British journal of sports medicine
pub_type: 杂志文章,随机对照试验
doi:10.1136/bjsports-2013-093360
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:In competitive alpine skiing, there is a controversy regarding the sex-related risk of injury. OBJECTIVE:To compare the risk of injury in female versus male World Cup (WC) alpine skiers. METHODS:Injuries were recorded through the International Ski Federation Injury Surveillance System for six consecutive w...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsports-2013-092206
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVES:As physical activity is promoted as part of a healthy lifestyle, sports injuries are becoming an important public health concern in many countries. The objective of this study is to investigate rates of sports injuries before and after implementation of a WHO Safe Community program. METHODS:Sports injury da...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.2004.014472
更新日期:2005-07-01 00:00:00
abstract:BACKGROUND:Home and supervised exercise programmes consisting of stretching and eccentric exercises have been recommended for the management of lateral elbow tendinopathy (LET). No studies have examined their comparative efficacy effectiveness. OBJECTIVE:In this study, whether a home exercise programme is more success...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.2008.049759
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:Salbutamol has been shown to mediate anabolic effects after intravenous administration. However, the mechanism responsible for the anabolic actions of salbutamol remains unknown. AIM:To investigate the potential mechanism by which salbutamol mediates anabolic effects in vitro. METHODS:The potential androge...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.2007.035162
更新日期:2007-12-01 00:00:00
abstract::Athletes such as skaters and skiers inhale large volumes of cold air during exercise and shift from nasal to mouth breathing. Endurance athletes, like cross-country skiers, perform at 80% or more of their maximal oxygen consumption and have minute ventilations in excess of 100 l/min. Cold air is always dry, and endura...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsports-2011-090822
更新日期:2012-05-01 00:00:00
abstract::In 1975 the authors sent a questionnaire to all players in the Norwegian First Division League Clubs to record the incidence of head injuries due to heading. The conclusion of the questionnaire is that there seems to be a low percentage of serious head injuries. None of the players had been operated on for epi- or sub...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.15.3.163
更新日期:1981-09-01 00:00:00
abstract:OBJECTIVE:To investigate the stride pattern of different age groups of veteran runners in a marathon road race. METHODS:This kinematic study investigated the stride pattern (stride length, stride period, velocity, stance time, and non-stance time) for 151 runners (78 men aged up to 75-80, 73 women aged up to 60-64) at...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.2006.026252
更新日期:2006-07-01 00:00:00
abstract:AIMS:To prospectively follow a cohort of elite young male professional soccer players with sequential symptom questionnaires and imaging of the anterior pelvis to determine the prevalence and severity of imaging findings. METHODS:34 male athletes (mean age 16.5 years) underwent clinical examination, history/symptom qu...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsports-2013-092932
更新日期:2015-02-01 00:00:00
abstract:AIM:The purpose of this study was to investigate the relationship between physical workload and injury risk in elite youth football players. METHODS:The workload data and injury incidence of 32 players were monitored throughout 2 seasons. Multiple regression was used to compare cumulative (1, 2, 3 and 4-weekly) loads ...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsports-2015-095820
更新日期:2017-03-01 00:00:00