Abstract:
BACKGROUND:Salbutamol has been shown to mediate anabolic effects after intravenous administration. However, the mechanism responsible for the anabolic actions of salbutamol remains unknown. AIM:To investigate the potential mechanism by which salbutamol mediates anabolic effects in vitro. METHODS:The potential androgenic activity of salbutamol was investigated in vitro by the A-Screen assay that measures androgen-dependent inhibition of proliferation of the androgen receptor (AR)-positive human mammary carcinoma cell line, MCF7-AR1. RESULTS:The assay was validated with three known androgens; methyltrienolone (R1881), 5alpha-dihydrotestosterone (DHT) and danazol. IC50 values of R1881, DHT and danazol, 4.41x10(-11), 4.44x10(-11) and 1.08x10(-8) M, respectively, were in the ranges known from earlier studies. Our results demonstrate that salbutamol exhibits androgenic activity, with an IC50 value of 8.93x10(-6) M. Anti-estrogenic or cytotoxic effects, which might have interfered with the assay, were excluded by additional experiments on wild-type MCF7 and MCF7-AR1 cells, respectively. CONCLUSION:These data indicate that salbutamol exerts anabolic effects through androgen receptor agonistic activity in vitro.
journal_name
Br J Sports Medjournal_title
British journal of sports medicineauthors
von Bueren AO,Ma R,Schlumpf M,Lichtensteiger Wdoi
10.1136/bjsm.2007.035162subject
Has Abstractpub_date
2007-12-01 00:00:00pages
874-8; discussion 878issue
12eissn
0306-3674issn
1473-0480pii
bjsm.2007.035162journal_volume
41pub_type
杂志文章abstract:OBJECTIVE:The use of muscle balancing by the clinician to determine return to activity or discharge of a patient is not a well understood measure. Because of the lack of information on the poorly understood concept of eccentric/concentric (E/C) ratios at the ankle, the purpose was to determine the E/C ratios for the in...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.33.4.255
更新日期:1999-08-01 00:00:00
abstract:BACKGROUND:The highest velocity that a runner can sustain during middle distance races is defined by the intersection of the runner's individual velocity-time curve and the distance-time curve. The velocity-time curve is presumably fixed at the onset of a race; however, whereas the race distance is ostensibly fixed, th...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.36.2.102
更新日期:2002-04-01 00:00:00
abstract:BACKGROUND:In this study we describe (1) the implementation of a novel web-based injury and illness surveillance system (WEB-IISS) for use by a team of physicians at multisport events and (2) the incidence and characteristics of injuries and illness in athletes during the London 2012 Paralympic Games. METHODS:Overall,...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsports-2013-092375
更新日期:2013-05-01 00:00:00
abstract::After an interval of ten years, physically active and inactive male university teachers were re-examined across four measures; predicted maximum oxygen uptake, percentage body fat, personality and attitudes towards physical activity. Both groups showed a decrease in predicted oxygen uptake and an increase in body fat ...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.20.4.174
更新日期:1986-12-01 00:00:00
abstract::Mechanotransduction is the physiological process where cells sense and respond to mechanical loads. This paper reclaims the term "mechanotherapy" and presents the current scientific knowledge underpinning how load may be used therapeutically to stimulate tissue repair and remodelling in tendon, muscle, cartilage and b...
journal_title:British journal of sports medicine
pub_type: 杂志文章,评审
doi:10.1136/bjsm.2008.054239
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:In adults, exercise is a powerful and natural stimulator of immune cells and adhesion molecules. Far less is known about exercise responses during childhood and adolescence and whether or not exercise in "real life" activities of healthy adolescents influences immune responses. OBJECTIVE:To determine if str...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.2002.002576
更新日期:2004-04-01 00:00:00
abstract:BACKGROUND/AIM:The Achilles tendon is a tissue that responds to mechanical loads at a molecular and cellular level. In vitro and in vivo studies have shown that the expression of anabolic and/or catabolic proteins can change within hours of loading and return to baseline levels within 72 h. These biochemical changes ha...
journal_title:British journal of sports medicine
pub_type: 杂志文章,随机对照试验
doi:10.1136/bjsports-2013-092713
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND/AIM:Consumer-based physical activity (PA) monitors have become popular tools to track PA behaviours. Currently, little is known about the validity of the measurements provided by consumer monitors. We aimed to compare measures of steps, energy expenditure (EE) and active minutes of four consumer monitors wit...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsports-2016-096990
更新日期:2018-07-01 00:00:00
abstract:OBJECTIVES:To investigate psychological correlates of exercise dependence in experienced and inexperienced bodybuilders and weightlifters. Secondary objectives included measuring social physique anxiety, bodybuilding identity, and social support among bodybuilders and weightlifters. METHODS:Thirty five experienced bod...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.34.6.431
更新日期:2000-12-01 00:00:00
abstract:INTRODUCTION:Rest until symptom-free, followed by a progressive stepwise return to activities, is often prescribed in the management of paediatric concussions. Recent evidence suggests prolonged rest may hinder recovery, and early resumption of physical activity may be associated with more rapid recovery postconcussion...
journal_title:British journal of sports medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/bjsports-2017-097981
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVE:To compare the prevalence of self reported, physician diagnosed osteoarthritis (OA) of the hip in ex-professional footballers with that in age matched controls in the general public. METHOD:A questionnaire was sent to the 92 football league and premiership managers to assess the prevalence of OA of various j...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.37.1.80
更新日期:2003-02-01 00:00:00
abstract:PURPOSE:To systematically review the scientific level of evidence for the 'Top 3' risk factors, screening tests and preventative exercises identified by a previously published survey of 44 premier league football (soccer) teams. Also, to provide an overall scientific level of evidence and graded recommendation based on...
journal_title:British journal of sports medicine
pub_type: 杂志文章,评审
doi:10.1136/bjsports-2014-094104
更新日期:2015-05-01 00:00:00
abstract::The objective is to provide guidance for pregnant women and obstetric care and exercise professionals on prenatal physical activity. The outcomes evaluated were maternal, fetal or neonatal morbidity, or fetal mortality during and following pregnancy. Literature was retrieved through searches of MEDLINE, EMBASE, PsycIN...
journal_title:British journal of sports medicine
pub_type: 杂志文章,实务指引
doi:10.1136/bjsports-2018-100056
更新日期:2018-11-01 00:00:00
abstract::It would seem that the development of a stress fracture results from unsuccessful adaptation of bone to a change in its mechanical environment caused by repetitive loading. It involves the physiological processes of microdamage production and remodelling. Whether the initiating factor is microdamage production or acti...
journal_title:British journal of sports medicine
pub_type: 杂志文章,评审
doi:10.1136/bjsm.30.3.200
更新日期:1996-09-01 00:00:00
abstract:BACKGROUND:Physical exercise is seen as a promising intervention to prevent or delay cognitive decline in individuals aged 50 years and older, yet the evidence from reviews is not conclusive. OBJECTIVES:To determine if physical exercise is effective in improving cognitive function in this population. DESIGN:Systemati...
journal_title:British journal of sports medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1136/bjsports-2016-096587
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVE:To examine differences in ad libitum fluid intake, comparing a 6% carbohydrate/electrolyte drink (CHO-E) and water, and associated differences in core temperature and other selected physiological and perceptual responses in adolescent athletes during tennis training in the heat. METHODS:Fourteen healthy, fit...
journal_title:British journal of sports medicine
pub_type: 杂志文章,随机对照试验
doi:10.1136/bjsm.2005.023333
更新日期:2006-05-01 00:00:00
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journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.2007.039479
更新日期:2008-03-01 00:00:00
abstract::The purpose of this study was to examine selected physiological characteristics and pushing performance over a distance of five kilometres (5 km) in twelve wheelchair athletes (10 paraplegics and 2 tetraplegics). The physiological tests and 5 km wheelchair time trials were performed on a motorised treadmill adapted fo...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.21.3.130
更新日期:1987-09-01 00:00:00
abstract:OBJECTIVES:To investigate the physiological characteristics of subelite junior and senior rugby league players and establish performance standards for these athletes. METHODS:A total of 159 junior (under 16, 15, 14, and 13, n = 88) and senior (first grade, second grade, and under 19, n = 71) rugby league players (forw...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.36.5.334
更新日期:2002-10-01 00:00:00
abstract::A previously well 30 year old man presented with a short history of intra-articular mechanical locking, swelling, and anteromedial joint line pain. There was localised tenderness, and McMurray's test was positive. Arthroscopy revealed a 3.6 x 2.6 x 1.5 cm firm pedicular localised pigmented villonodular synovitis origi...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.37.4.368
更新日期:2003-08-01 00:00:00
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journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.2005.020743
更新日期:2006-06-01 00:00:00
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journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.2005.018366
更新日期:2005-09-01 00:00:00
abstract::A total of 266 patients with injuries to the knee sustained during sports activities were managed by arthroscopy and/or arthrotomy. All of them received systemic examination and a standard battery of knee stability tests. Fifty-three were examined by arthrography and all underwent arthrotomy for surgical correction of...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.27.2.87
更新日期:1993-06-01 00:00:00
abstract::The aim of this review is to provide a concise overview and update on recent advances in the field of physical activity in childhood and its effects on bone growth with an emphasis on the potential to prevent fractures. In addition, the review poses several unresolved questions in the field for future research. ...
journal_title:British journal of sports medicine
pub_type: 杂志文章,评审
doi:10.1136/bjsports-2011-090188
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:Improved oxygen uptake improves soccer performance as regards distance covered, involvements with the ball, and number of sprints. Large improvements in oxygen uptake have been shown using interval running. A similar physiological load arising from interval running could be obtained using the soccer ball in ...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.2004.012526
更新日期:2005-05-01 00:00:00
abstract::Anabolic androgenic steroids (AAS) are used illicitly at high doses by bodybuilders. The misuse of these drugs is associated with serious adverse effects to the liver, including cellular adenomas and adenocarcinomas. We report two very different cases of adult male bodybuilders who developed hepatocellular adenomas fo...
journal_title:British journal of sports medicine
pub_type: 杂志文章,评审
doi:10.1136/bjsm.2004.013599
更新日期:2005-05-01 00:00:00
abstract:OBJECTIVE:Para athletes reap significant health benefits from sport but are vulnerable to non-accidental harms. Little is known about the types and impacts of non-accidental harms Para athletes face. In this literature review, we summarise current knowledge and suggest priorities for future research related to non-acci...
journal_title:British journal of sports medicine
pub_type: 杂志文章,评审
doi:10.1136/bjsports-2018-099854
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:Tendinopathies of the rotator cuff muscles, biceps tendon and pectoralis major muscle are common causes of shoulder pain in athletes. Overuse insertional tendinopathy of pectoralis minor is a previously undescribed cause of shoulder pain in weightlifters/sportsmen. OBJECTIVES:To describe the clinical featur...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.2006.032383
更新日期:2007-08-01 00:00:00
abstract::Athletes such as skaters and skiers inhale large volumes of cold air during exercise and shift from nasal to mouth breathing. Endurance athletes, like cross-country skiers, perform at 80% or more of their maximal oxygen consumption and have minute ventilations in excess of 100 l/min. Cold air is always dry, and endura...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsports-2011-090822
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND:In the International Ski Federation (FIS), World Cup (WC) snowboard cross (SBX) and ski cross (SX), the injury incidence in individual qualification runs versus final runs in heats of four athletes is unknown. Objective To investigate the injury incidence in individual qualification runs versus final runs of...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsports-2011-090528
更新日期:2011-12-01 00:00:00