Abstract:
:The Rho-family proteins make up a major branch of the Ras superfamily of small GTPases. To date, 22 human genes encoding at least 25 proteins have been described. The best known 'classical' members are RhoA, Rac1 and Cdc42. Highly related isoforms of these three proteins have not been studied as intensively, in part because it has been assumed that they are functionally identical to their better-studied counterparts. This now appears not to be the case. Variations in C-terminal-signaled modifications and subcellular targeting cause otherwise highly biochemically related isoforms (e.g. RhoA, RhoB and RhoC) to exhibit surprisingly divergent biological activities. Whereas the classical Rho GTPases are regulated by GDP/GTP cycling, other Rho GTPases are also regulated by other mechanisms, particularly by transcriptional regulation. Newer members of the family possess additional sequence elements beyond the GTPase domain, which suggests they exhibit yet other mechanisms of regulation.
journal_name
J Cell Scijournal_title
Journal of cell scienceauthors
Wennerberg K,Der CJdoi
10.1242/jcs.01118keywords:
subject
Has Abstractpub_date
2004-03-15 00:00:00pages
1301-12issue
Pt 8eissn
0021-9533issn
1477-9137pii
117/8/1301journal_volume
117pub_type
杂志文章,评审abstract::Notch signalling is used throughout the animal kingdom to spatially and temporally regulate cell fate, proliferation and differentiation. Its importance is reflected in the dramatic effects produced on both development and health by small variations in the strength of the Notch signal. The Down-syndrome-associated kin...
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journal_title:Journal of cell science
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journal_title:Journal of cell science
pub_type: 杂志文章
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doi:
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journal_title:Journal of cell science
pub_type: 杂志文章
doi:
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journal_title:Journal of cell science
pub_type: 杂志文章
doi:
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journal_title:Journal of cell science
pub_type: 杂志文章
doi:10.1242/jcs.085118
更新日期:2012-01-01 00:00:00
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journal_title:Journal of cell science
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更新日期:2009-06-15 00:00:00
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journal_title:Journal of cell science
pub_type: 杂志文章
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更新日期:2011-10-15 00:00:00
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journal_title:Journal of cell science
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更新日期:2018-05-04 00:00:00
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journal_title:Journal of cell science
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doi:10.1242/jcs.145565
更新日期:2014-07-01 00:00:00
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journal_title:Journal of cell science
pub_type: 杂志文章
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