Abstract：
:Membrane contact sites (MCSs), where the membranes of two organelles are closely apposed, are regions where small molecules such as lipids or calcium are exchanged between organelles. We have identified a conserved membrane-binding domain found exclusively in proteins at MCSs in Saccharomyces cerevisiae. The synaptotagmin-like-mitochondrial-lipid binding protein (SMP) domain is conserved across species. We show that all seven proteins that contain this domain in yeast localize to one of three MCSs. Human proteins with SMP domains also localize to MCSs when expressed in yeast. The SMP domain binds membranes and is necessary for protein targeting to MCSs. Proteins containing this domain could be involved in lipid metabolism. This is the first protein domain found exclusively in proteins at MCSs.
journal_name
J Cell Scijournal_title
Journal of cell scienceauthors
Toulmay A,Prinz WAdoi
10.1242/jcs.085118subject
Has Abstractpub_date
2012-01-01 00:00:00pages
49-58issue
Pt 1eissn
0021-9533issn
1477-9137pii
jcs.085118journal_volume
125pub_type
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