Glycosaminoglycans inhibit Candida albicans adherence to extracellular matrix proteins.

Abstract:

:The ability of Candida albicans to adhere to subendothelial extracellular matrix (ECM) may be important in the pathogenesis of disseminated candidiasis. ECM proteins, such as fibronectin, laminin, and types I and IV collagen bind C. albicans avidly. These proteins all possess heparin-binding domains. The influence of the glycosaminoglycans (GAGS) including heparin, heparan sulfate and dextran sulfate on C. albicans adherence to subendothelial ECM and ECM proteins was studied. It was demonstrated that the GAGS inhibited C. albicans adherence to ECM and ECM proteins. This possibly occurred by the GAGS binding to the ECM proteins and, in so doing, masking a preferred ligand for C. albicans adherence.

journal_name

FEMS Microbiol Lett

authors

Klotz SA,Smith RL

doi

10.1016/0378-1097(92)90026-k

keywords:

subject

Has Abstract

pub_date

1992-12-01 00:00:00

pages

205-8

issue

2-3

eissn

0378-1097

issn

1574-6968

journal_volume

78

pub_type

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