Abstract:
:Chlamydophila pneumoniae infection is associated with a range of diseases including pneumonia, asthma and heart disease. Although an obligate intracellular pathogen, high levels of antigen-specific antibody are induced and serology is frequently used to diagnose these infections. Proteins targeted by the humoral response include the major outer membrane protein (MOMP) and outer membrane protein 2 (OMP2). Using human anti-chlamydial sera we have defined the B cell epitopes recognized on MOMP and OMP2. Peptides from MOMP, unlike OMP2, were not strongly recognized. Two of these epitopes when linked to an inert carrier reacted strongly with high-titer anti-C. pneumoniae sera.
journal_name
FEMS Microbiol Lettjournal_title
FEMS microbiology lettersauthors
Cunningham AF,Ward MEdoi
10.1016/S0378-1097(03)00650-5keywords:
subject
Has Abstractpub_date
2003-10-10 00:00:00pages
73-9issue
1eissn
0378-1097issn
1574-6968pii
S0378109703006505journal_volume
227pub_type
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