Ability of human sera to neutralise the activity of Vero cytotoxins VT1, VT2 and variant forms of VT2.

Abstract:

:Sera, from 17 patients with diarrhoea or haemolytic uraemic syndrome, and six healthy adults, were tested for neutralisation of Vero cytotoxins (VT). For all 17 patients there was evidence of infection with Escherichia coli O157. Sera from two controls but from none of the patients neutralised VT1, although two patients were infected by strains producing VT1 and VT2. Sera from all six controls and 14 patients neutralised VT2 derived from strains 933 and E32511, but not variant forms of VT2 derived from strains E32511, E57, B2F1 and H.1.8. This neutralising activity warrants further investigation, especially as many O157 VTEC carry both VT2 and VT2 variant genes.

journal_name

FEMS Microbiol Lett

authors

Scotland SM,Said B,Thomas A,Rowe B

doi

10.1111/j.1574-6968.1994.tb06652.x

subject

Has Abstract

pub_date

1994-01-15 00:00:00

pages

285-9

issue

2-3

eissn

0378-1097

issn

1574-6968

journal_volume

115

pub_type

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