EFFECT OF TETRACYCLINES ON THE INTRACELLULAR AMINO ACIDS OF MOLDS.

Abstract:

:Freeman, Bob A. (University of Chicago, Chicago, Ill.) and Richard Circo. Effect of tetracyclines on the intracellular amino acids of molds. J. Bacteriol. 86:38-44. 1963.-The tetracycline antibiotics were shown to alter the amino acid metabolism of molds whose growth is not markedly affected. Eight molds were grown in the presence of these antiobiotics; four exhibited a general reduction in the concentration of the intracellular amino acids, except for glutamic acid and alanine. In most of these four cultures, the tetracyclines also caused the complete disappearance of arginine, lysine, proline, phenylalanine, and tyrosine from the intracellular amino acid pool. The significance of these observations and the usefulness of the method in the study of the mechanisms of antibiotic action are discussed.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

FREEMAN BA,CIRCO R

doi

10.1128/JB.86.1.38-44.1963

keywords:

subject

Has Abstract

pub_date

1963-07-01 00:00:00

pages

38-44

eissn

0021-9193

issn

1098-5530

journal_volume

86

pub_type

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