RESISTANCE AND CROSS RESISTANCE OF ESCHERICHIA COLI S MUTANTS TO THE RADIOMIMETIC AGENT NITROFURAZONE.

Abstract:

:Woody-Karrer, Pearl (Palo Alto Medical Research Foundation, Palo Alto, Calif.) and Joseph Greenberg. Resistance and cross resistance of Escherichia coli S mutants to the radiomimetic agent nitrofurazone. J. Bacteriol. 85:1208-1216. 1963.-Cross-resistance relationships are described for 73 mutants of Escherichia coli strain S selected in one step for resistance to nitrofurazone. The test agents included ultraviolet radiation, five radiomimetic compounds, and penicillin; 12 different types of mutants could be selected. Two of these were chemoresistant, three were identical to radioresistant types previously isolated by use of other radiomimetic agents, and seven represented previously unobserved radioresistant types. The majority of radioresistant strains did not respond to plating-medium reactivation after ultraviolet radiation, despite the ultraviolet radiation responses of several minority representative strains. The data presented indicate that radioresistance in E. coli S does not involve resistance to most toxic agents; on the other hand, cross resistance to radiomimetic compounds is not restricted to alkylating agents.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

WOODY-KARRER P,GREENBERG J

doi

10.1128/JB.85.6.1208-1216.1963

keywords:

subject

Has Abstract

pub_date

1963-06-01 00:00:00

pages

1208-16

eissn

0021-9193

issn

1098-5530

journal_volume

85

pub_type

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