Abstract:
:The tubercle bacillus parasitizes macrophages by inhibiting phagosome maturation into the phagolysosome. This phenomenon underlies the tuberculosis pandemic involving 2 billion people. We report here how Mycobacterium tuberculosis causes phagosome maturation arrest. A glycosylated M. tuberculosis phosphatidylinositol [mannose-capped lipoarabinomannan (ManLAM)] interfered with the phagosomal acquisition of the lysosomal cargo and syntaxin 6 from the trans-Golgi network. ManLAM specifically inhibited the pathway dependent on phosphatidylinositol 3-kinase activity and phosphatidylinositol 3-phosphate-binding effectors. These findings identify ManLAM as the M. tuberculosis product responsible for the inhibition of phagosomal maturation.
journal_name
Proc Natl Acad Sci U S Aauthors
Fratti RA,Chua J,Vergne I,Deretic Vdoi
10.1073/pnas.0737613100keywords:
subject
Has Abstractpub_date
2003-04-29 00:00:00pages
5437-42issue
9eissn
0027-8424issn
1091-6490pii
0737613100journal_volume
100pub_type
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