Illusory motion perception in blindsight.

abstract：:A high proportion of human B cells carry B-cell receptors (BCRs) that are autoreactive. Inhibitory receptors such as CD22 can downmodulate autoreactive BCR responses. With its extracellular domain, CD22 binds to sialic acids in α2,6 linkages in cis, on the surface of the same B cell or in trans, on other cells. Sialic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Müller J,Obermeier I,Wöhner M,Brandl C,Mrotzek S,Angermüller S,Maity PC,Reth M,Nitschke L

更新日期：2013-07-23 00:00:00

abstract：:Human Creutzfeldt-Jakob disease (CJD) and similar neurodegenerative diseases such as sheep scrapie are caused by a variety of related infectious agents. They are associated with abnormal host prion protein (PrP), which is assessed by limited proteolysis to yield resistant PrP bands (PrP-res). Although PrP-res has been...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arjona A,Simarro L,Islinger F,Nishida N,Manuelidis L

更新日期：2004-06-08 00:00:00

abstract：:ATP-dependent DNA supercoiling catalyzed by Escherichia coli DNA gyrase was inhibited by oxolinic acid, a compound similar to but more potent than nalidixic acid and a known inhibitor of DNA replication in E. coli. The supercoiling activity of DNA gyrase purified from nalidixic acid-resistant mutant (nalA(R)) bacteria...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gellert M,Mizuuchi K,O'Dea MH,Itoh T,Tomizawa JI

更新日期：1977-11-01 00:00:00

abstract：:Online education is rapidly expanding in response to rising demand for higher and continuing education, but many online students struggle to achieve their educational goals. Several behavioral science interventions have shown promise in raising student persistence and completion rates in a handful of courses, but evid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kizilcec RF,Reich J,Yeomans M,Dann C,Brunskill E,Lopez G,Turkay S,Williams JJ,Tingley D

更新日期：2020-06-30 00:00:00

abstract：:Citrus bacterial canker (CBC) caused by Xanthomonas axonopodis pv. citri (Xac) was first documented in India and Java in the mid 19th century. Since that time, the known distribution of the disease has steadily increased. Concurrent with the dispersion of the pathogen, the diversity of described strains continues to i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li W,Song Q,Brlansky RH,Hartung JS

更新日期：2007-11-20 00:00:00

abstract：:Benzophenones are among the most useful photocrosslinking agents in biology. We have evolved an orthogonal aminoacyl-tRNA synthetase/tRNA pair that makes possible the in vivo incorporation of p-benzoyl-l-phenylalanine into proteins in Escherichia coli in response to the amber codon, TAG. This unnatural amino acid was ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chin JW,Martin AB,King DS,Wang L,Schultz PG

更新日期：2002-08-20 00:00:00

abstract：:Methane can be converted to triose dihydroxyacetone (DHA) by chemical processes with formaldehyde as an intermediate. Carbon dioxide, a by-product of various industries including ethanol/butanol biorefineries, can also be converted to formaldehyde and then to DHA. DHA, upon entry into a cell and phosphorylation to DHA...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang L,Chauliac D,Rhee MS,Panneerselvam A,Ingram LO,Shanmugam KT

更新日期：2018-04-24 00:00:00

abstract：:Several of the best-studied sex differences in the mammalian brain are ascribed to the hormonal control of cell death. This conclusion is based primarily on correlations between pyknotic cell counts in development and counts of mature neurons in adulthood; the molecular mechanisms of hormone-regulated, sexually dimorp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Forger NG,Rosen GJ,Waters EM,Jacob D,Simerly RB,de Vries GJ

更新日期：2004-09-14 00:00:00

abstract：:The X gene product encoded by the hepatitis B virus, termed pX, is a promiscuous transactivator of a variety of viral and cellular genes under the control of diverse cis-acting elements. Although pX does not appear to directly bind DNA, pX-responsive elements include the NF-kappa B, AP-1, and CRE (cAMP response elemen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Williams JS,Andrisani OM

更新日期：1995-04-25 00:00:00

abstract：:This article extends our previous quantitative analysis of the relationship between the dynamics of the primary structure of DNA and mutagenesis associated with single-strand lesions to an analysis of the production and processing of endogenous double-strand breaks (EDSBs) and to their implications for oncogenesis. We...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vilenchik MM,Knudson AG

更新日期：2003-10-28 00:00:00

abstract：:The receptor-like tyrosine kinase (Ryk), a Wnt receptor, is important for cell fate determination during corticogenesis. During neuronal differentiation, the Ryk intracellular domain (ICD) is cleaved. Cleavage of Ryk and nuclear translocation of Ryk-ICD are required for neuronal differentiation. However, the mechanism...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang WH,Choi SH,Moon BS,Cai M,Lyu J,Bai J,Gao F,Hajjali I,Zhao Z,Campbell DB,Weiner LP,Lu W

更新日期：2017-12-12 00:00:00

abstract：:Deamidation of asparaginyl and glutaminyl residues causes time-dependent changes in charge and conformation of peptides and proteins. Quantitative and experimentally verified predictive calculations of the deamidation rates of 1,371 asparaginyl residues in a representative collection of 126 human proteins have been pe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Robinson NE,Robinson AB

更新日期：2001-10-23 00:00:00

abstract：:To characterize the region on human IgG1 responsible for its high-affinity interaction with the human Fc gamma receptor class I (Fc gamma RI), we have analyzed the binding properties of a series of genetically engineered chimeric antidinitrophenyl antibodies with identical murine antibody combining sites and hybrid Ig...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chappel MS,Isenman DE,Everett M,Xu YY,Dorrington KJ,Klein MH

更新日期：1991-10-15 00:00:00

abstract：:Blindsight is a phenomenon in which human patients with damage to striate cortex deny any visual sensation in the resultant visual field defect but can nonetheless detect and localize stimuli when persuaded to guess. Although monkeys with striate lesions have also been shown to exhibit some residual vision, it is not ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moore T,Rodman HR,Repp AB,Gross CG

更新日期：1995-08-29 00:00:00

abstract：:Although the future often seems intangible, we can make it more concrete by imagining prospective events. Here, using functional MRI, we demonstrate a mechanism by which the ventromedial prefrontal cortex supports such episodic simulations, and thereby contributes to affective foresight: This region supports processes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benoit RG,Szpunar KK,Schacter DL

更新日期：2014-11-18 00:00:00

abstract：:The adenosine deaminases that act on RNA (ADARs) catalyze the site-specific conversion of adenosine to inosine (A to I) in primary mRNA transcripts, thereby affecting the splicing pattern or coding potential of mature mRNAs. Although the subnuclear localization of A-to-I editing has not been precisely defined, ADARs h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sansam CL,Wells KS,Emeson RB

更新日期：2003-11-25 00:00:00

abstract：:Precipitates of hemoglobin, termed Heinz bodies, occur in a fraction of erythrocytes after removal of the spleen and are also observed in aged erythrocytes. This implies that precipitates of hemoglobin might play a particular role in senescent cell recognition. By using immunofluorescence microscopy, evidence is prese...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schlüter K,Drenckhahn D

更新日期：1986-08-01 00:00:00

abstract：:When the lactose (lac) permease of Escherichia coli is expressed from the lac promoter at relatively low rates, deletion of amino acid residues 2-8 (delta 7) or 2-9 (delta 8) from the hydrophilic N terminus has a relatively minor effect on the ability of the permease to catalyze active lactose transport. Activity is e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bibi E,Stearns SM,Kaback HR

更新日期：1992-04-15 00:00:00

abstract：:Dietary restriction has been shown to have several health benefits including increased insulin sensitivity, stress resistance, reduced morbidity, and increased life span. The mechanism remains unknown, but the need for a long-term reduction in caloric intake to achieve these benefits has been assumed. We report that w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Anson RM,Guo Z,de Cabo R,Iyun T,Rios M,Hagepanos A,Ingram DK,Lane MA,Mattson MP

更新日期：2003-05-13 00:00:00

abstract：:Studies of tumors from human familial adenomatous polyposis, sporadic colon cancer, and mouse and rat models of intestinal cancer indicate that the majority of early adenomas develop through loss of normal function of the Adenomatous polyposis coli (APC) gene. In murine models of familial adenomatous polyposis, specif...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Amos-Landgraf JM,Irving AA,Hartman C,Hunter A,Laube B,Chen X,Clipson L,Newton MA,Dove WF

更新日期：2012-02-07 00:00:00

abstract：:The recent demonstration of K+ channel dysfunction in fibroblasts from Alzheimer disease (AD) patients and past observations of Ca(2+)-mediated K+ channel modulation during memory storage suggested that AD, which is characterized by memory loss and other cognitive deficits, might also involve dysfunction of intracellu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ito E,Oka K,Etcheberrigaray R,Nelson TJ,McPhie DL,Tofel-Grehl B,Gibson GE,Alkon DL

更新日期：1994-01-18 00:00:00

abstract：:A promising strategy for DNA sequencing exploits transposons to provide mobile sites for the binding of sequencing primers. For such a strategy to be maximally efficient, the location and orientation of the transposon must be readily determined and the insertion sites should be randomly distributed. We demonstrate an ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Strausbaugh LD,Bourke MT,Sommer MT,Coon ME,Berg CM

更新日期：1990-08-01 00:00:00

abstract：:Of the microsomal P450 cytochromes, the ethanol-inducible isoform, P450 2E1, is believed to be predominant in leading to oxidative damage, including the generation of radical species that contribute to lipid peroxidation, and in the reductive beta-scission of lipid hydroperoxides to give hydrocarbons and aldehydes. In...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bestervelt LL,Vaz AD,Coon MJ

更新日期：1995-04-25 00:00:00

abstract：:Addition of acetylcholine to growing cultures of mouse neuroblastoma cells induced a 37-fold increase in the specific activity of acetylcholinesterase (EC 3.1.1.7). Morphological changes, consisting of neurite-extensions, were also observed during the logarithmic phase of growth of cells stimulated with acetylcholine....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harkins J,Arsenault M,Schlesinger K,Kates J

更新日期：1972-11-01 00:00:00

abstract：:We isolated mutant strains of the facultative anaerobe Salmonella typhimurium that grow either aerobically or anaerobically. Strict anaerobic mutants contained a defective DNA topoisomerase I gene (topI), while strict aerobic mutants contained a defective DNA gyrase subunit A gene (gyrA, also nalA). Topoisomerase I ac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamamoto N,Droffner ML

更新日期：1985-04-01 00:00:00

abstract：:We have investigated the frequency of p53 mutations in B- and T-cell human lymphoid malignancies, including acute lymphoblastic leukemia, the major subtypes of non-Hodgkin lymphoma, and chronic lymphocytic leukemia. p53 exons 5-9 were studied by using genomic DNA from 197 primary tumors and 27 cell lines by single-str...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gaidano G,Ballerini P,Gong JZ,Inghirami G,Neri A,Newcomb EW,Magrath IT,Knowles DM,Dalla-Favera R

更新日期：1991-06-15 00:00:00

abstract：:Mouse L929 cells were incubated with antibody-targeted liposomes containing oligodeoxyribonucleotides (oligomers). When the oligomer was a 15-mer complementary to the 5'-end region of the mRNA encoding the N protein of vesicular stomatitis virus, the cells became less permissive for multiplication of that virus; great...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leonetti JP,Machy P,Degols G,Lebleu B,Leserman L

更新日期：1990-04-01 00:00:00

abstract：:In Gram-negative bacteria, the outer membrane contains primarily β-barrel transmembrane proteins and lipoproteins. The insertion and assembly of β-barrel outer-membrane proteins (OMPs) is mediated by the β-barrel assembly machinery (BAM) complex, the core component of which is the 16-stranded transmembrane β-barrel Ba...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lundquist K,Bakelar J,Noinaj N,Gumbart JC

更新日期：2018-08-21 00:00:00

abstract：:The TCR is an alpha beta heterodimer, a part of the multimeric structure through which physiological T-cell activation occurs. The expression of TCR alpha chain is greatly diminished in a beta-chain-deficient mutant Jurkat cell line (J.RT3-T3.5). The relationship between the expression of the TCR alpha and beta chains...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chung S,Strominger JL

更新日期：1995-04-25 00:00:00

abstract：:Recombinant DNA techniques have been combined with somatic cell genetic methods to identify, isolate, and amplify fragments of human DNA localized at specific regions of human chromosome 11 selected as a model system. A library of genomic DNA segments has been constructed, in lambda Charon 4A bacteriophage, from the D...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gusella JF,Keys C,VarsanyiBreiner A,Kao FT,Jones C,Puck TT,Housman D

更新日期：1980-05-01 00:00:00