Modulation of RNA editing by functional nucleolar sequestration of ADAR2.

abstract：:This paper explores the explanations for, and consequences of, the early appearance of food production outside the Fertile Crescent of Southwest Asia, where it originated in the 10th/9th millennia cal BC. We present evidence that cultivation appeared in Central Anatolia through adoption by indigenous foragers in the m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baird D,Fairbairn A,Jenkins E,Martin L,Middleton C,Pearson J,Asouti E,Edwards Y,Kabukcu C,Mustafaoğlu G,Russell N,Bar-Yosef O,Jacobsen G,Wu X,Baker A,Elliott S

更新日期：2018-04-03 00:00:00

abstract：:High-valent intermediates of binuclear nonheme iron enzymes are structurally unknown despite their importance for understanding enzyme reactivity. Nuclear resonance vibrational spectroscopy combined with density functional theory calculations has been applied to structurally well-characterized high-valent mono- and di...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park K,Bell CB 3rd,Liu LV,Wang D,Xue G,Kwak Y,Wong SD,Light KM,Zhao J,Alp EE,Yoda Y,Saito M,Kobayashi Y,Ohta T,Seto M,Que L Jr,Solomon EI

更新日期：2013-04-16 00:00:00

abstract：:Development of effective chemopreventive agents against prostate cancer (CaP) for humans requires conclusive evidence of their efficacy in animal models that closely emulates human disease. The autochthonous transgenic adenocarcinoma of the mouse prostate (TRAMP) model, which spontaneously develops metastatic CaP, is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gupta S,Hastak K,Ahmad N,Lewin JS,Mukhtar H

更新日期：2001-08-28 00:00:00

abstract：:BALB/c mice immunized with myeloma proteins 315 or 460 made antibodies to the individually specific ("idiotypic") determinants of these proteins and suppressed growth of the corresponding transplanted tumor cells (MOPC-315 or MOPC-460). Stable, variant MOPC-315 tumors that produce only the light chain of protein 315 g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lynch RG,Graff RJ,Sirisinha S,Simms ES,Eisen HN

更新日期：1972-06-01 00:00:00

abstract：:Helicobacter pylori is a Gram-negative bacterial pathogen with a small genome of 1.64-1.67 Mb. More than 20 putative DNA restriction-modification (R-M) systems, comprising more than 4% of the total genome, have been identified in the two completely sequenced H. pylori strains, 26695 and J99, based on sequence similari...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin LF,Posfai J,Roberts RJ,Kong H

更新日期：2001-02-27 00:00:00

abstract：:The primary structure of the precursor of urotensin I, a neuropeptide hormone from the caudal neurosecretory system of the carp Cyprinus carpio, has been determined by analyzing the nucleotide sequence of cloned DNA complementary to the mRNA encoding it. The precursor consists of 145 amino acid residues and the carbox...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ishida I,Ichikawa T,Deguchi T

更新日期：1986-01-01 00:00:00

abstract：:Genetic and taxonomic distances were computed for 3466 samples of human populations in Europe based on 97 allele frequencies and 10 cranial variables. Since the actual samples employed differed among the genetic systems studied, the genetic distances were computed separately for each system, as were matrices of geogra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sokal RR

更新日期：1988-03-01 00:00:00

abstract：:Entamoeba histolytica is a single cell eukaryote that is the etiologic agent of amoebic colitis. Core promoter elements of E. histolytica protein encoding genes include a TATA-like sequence (GTATTTAAAG/C) at -30, a novel element designated GAAC (GAACT) that has a variable location between TATA and the site of transcri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Singh U,Rogers JB,Mann BJ,Petri WA Jr

更新日期：1997-08-05 00:00:00

abstract：:There is not a single pharmaceutical that halts or even slows any neurodegenerative disease. Mounting evidence shows that prions cause many neurodegenerative diseases, and arguably, scrapie and Creutzfeldt-Jakob disease prions represent the best therapeutic targets. We report here that the previously identified 2-amin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berry DB,Lu D,Geva M,Watts JC,Bhardwaj S,Oehler A,Renslo AR,DeArmond SJ,Prusiner SB,Giles K

更新日期：2013-10-29 00:00:00

abstract：:The cDNA of the gene pds from tomato, encoding the carotenoid biosynthesis enzyme phytoene desaturase, was cloned, and its nucleotide sequence was determined. Cells of Escherichia coli that expressed the tomato pds gene could convert phytoene to zeta-carotene. This result suggests that one polypeptide, the product of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pecker I,Chamovitz D,Linden H,Sandmann G,Hirschberg J

更新日期：1992-06-01 00:00:00

abstract：:Control over the fluorescence of supramolecular assemblies is crucial for the development of chemosensors and light-emitting materials. Consequently, the postsynthetic modification of supramolecular structures via host-guest interactions has emerged as an efficient strategy in recent years that allows the facile tunin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang M,Yin S,Zhang J,Zhou Z,Saha ML,Lu C,Stang PJ

更新日期：2017-03-21 00:00:00

abstract：:ROOT MERISTEM GROWTH FACTOR (RGF) 1 is an important peptide hormone that regulates root growth. Upon binding to its receptor, RGFR1, RGF1 regulates the expression of two transcription factors, PLETHORA 1 and 2 (PLT1/2), to influence root meristem development. Here, we show that the ubiquitin-specific proteases UBP12 a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： An Z,Liu Y,Ou Y,Li J,Zhang B,Sun D,Sun Y,Tang W

更新日期：2018-01-30 00:00:00

abstract：:Species expanding into new habitats as a result of climate change or human introductions will frequently encounter resident competitors. Theoretical models suggest that such interspecific competition can alter the speed of expansion and the shape of expanding range boundaries. However, competitive interactions are rar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Legault G,Bitters ME,Hastings A,Melbourne BA

更新日期：2020-10-27 00:00:00

abstract：:The nuclear receptor corepressor, silencing mediator of retinoid and thyroid hormone receptors (SMRT), is recruited by a plethora of transcription factors to mediate lineage and signal-dependent transcriptional repression. We generated a knockin mutation in the receptor interaction domain (RID) of SMRT (SMRT(mRID)) th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nofsinger RR,Li P,Hong SH,Jonker JW,Barish GD,Ying H,Cheng SY,Leblanc M,Xu W,Pei L,Kang YJ,Nelson M,Downes M,Yu RT,Olefsky JM,Lee CH,Evans RM

更新日期：2008-12-16 00:00:00

abstract：:The assembly and composition of human excision nuclease were investigated by electrophoretic mobility shift assay and DNase I footprinting. Individual repair factors or any combination of up to four repair factors failed to form DNA-protein complexes of high specificity and stability. A stable complex of high specific...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wakasugi M,Sancar A

更新日期：1998-06-09 00:00:00

abstract：:We describe a synthetic ligand, "DAKLI" (Dynorphin A-analogue Kappa LIgand), related to the opioid peptide dynorphin A. A single reactive amino group at the extended carboxyl terminus permits various reporter groups to be attached, such as 125I-labeled Bolton-Hunter reagent, fluorescein isothiocyanate, or biotin. Thes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goldstein A,Nestor JJ Jr,Naidu A,Newman SR

更新日期：1988-10-01 00:00:00

abstract：:The apparent failure of infants to understand "object permanence" by reaching for hidden objects is perhaps the most striking and debated phenomenon in cognitive development. Of particular interest is the extent to which infants perceive and remember objects in a similar way to that of adults. Here we report two findi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaufman J,Csibra G,Johnson MH

更新日期：2005-10-18 00:00:00

abstract：:The amount of extra-pair paternity in socially monogamous bird species varies from 0% to 76% extra-pair offspring. The causes of this remarkable interspecific variation are largely unknown, although intraspecific analyses suggest that females seek extra-pair matings to improve the genetic quality of their offspring. I...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Petrie M,Doums C,Moller AP

更新日期：1998-08-04 00:00:00

abstract：:Plant genetic engineering led to the production of plant-derived mAb (mAbP), which provides a safe and economically feasible alternative to the current methods of antibody production in animal systems. In this study, the heavy and light chains of human anti-rabies mAb were expressed and assembled in planta under the c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ko K,Tekoah Y,Rudd PM,Harvey DJ,Dwek RA,Spitsin S,Hanlon CA,Rupprecht C,Dietzschold B,Golovkin M,Koprowski H

更新日期：2003-06-24 00:00:00

abstract：:Identification of genomic regions that control tissue-specific gene expression is currently problematic. ChIP and high-throughput sequencing (ChIP-seq) of enhancer-associated proteins such as p300 identifies some but not all enhancers active in a tissue. Here we show that co-occupancy of a chromatin region by multiple...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： He A,Kong SW,Ma Q,Pu WT

更新日期：2011-04-05 00:00:00

abstract：:Avian homologues of mammalian gamma delta and alpha beta T-cell antigen receptors, TCR1 and TCR2, have been identified with monoclonal antibodies. These TCR isotypes are associated with the avian CD3 proteins on the T-cell surface. During chick development, T-cell subpopulations bearing CD3/TCR1 or CD3/TCR2 receptor c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen CH,Sowder JT,Lahti JM,Cihak J,Lösch U,Cooper MD

更新日期：1989-04-01 00:00:00

abstract：:Flowering time (FT) is the developmental transition coupling an internal genetic program with external local and seasonal climate cues. The genetic loci sensitive to predictable environmental signals underlie local adaptation. We dissected natural variation in FT across a new global diversity set of 473 unique accessi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li Y,Huang Y,Bergelson J,Nordborg M,Borevitz JO

更新日期：2010-12-07 00:00:00

abstract：:During the developmental process of the Gram-negative soil bacterium Myxococcus xanthus, vegetatively growing rod cells differentiate to ultimately become metabolically quiescent and environmentally resistant myxospores encased within fruiting bodies. This program, initiated by nutrient deprivation, is propagated by b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tzeng L,Singer M

更新日期：2005-10-04 00:00:00

abstract：:Charybdotoxin (ChTX), a K+ channel blocker, depolarizes human peripheral T lymphocytes and renders them insensitive to activation by mitogen. We observed four types of K+ channels in human T cells: one voltage-activated, and three Ca(2+)-activated. To discern the mechanism by which ChTX depolarizes T cells, we examine...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leonard RJ,Garcia ML,Slaughter RS,Reuben JP

更新日期：1992-11-01 00:00:00

abstract：:Human breast cancers contain an RNA related to that of mouse mammary tumor virus. In 79% of the breast malignancies examined, this type of RNA is a 70S-component encapsulated with RNA-instructed DNA polymerase in a particle possessing the density characteristics of RNA tumor viruses. Further, the DNA synthesized by th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Axel R,Gulati SC,Spiegelman S

更新日期：1972-11-01 00:00:00

abstract：:Antibody modulation of T-cell coinhibitory (e.g., CTLA-4) or costimulatory (e.g., 4-1BB) receptors promotes clinical responses to a variety of cancers. Therapeutic cancer vaccination, in contrast, has produced limited clinical benefit and no curative therapies. The E6 and E7 oncoproteins of human papilloma virus (HPV)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bartkowiak T,Singh S,Yang G,Galvan G,Haria D,Ai M,Allison JP,Sastry KJ,Curran MA

更新日期：2015-09-22 00:00:00

abstract：:Fish stocks experiencing high fishing mortality show a tendency to mature earlier and at a smaller size, which may have a genetic component and therefore long-lasting economic and biological effects. To date, the economic effects of such ecoevolutionary dynamics have not been empirically investigated. Using 70 y of da...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eikeset AM,Richter A,Dunlop ES,Dieckmann U,Stenseth NC

更新日期：2013-07-23 00:00:00

abstract：:The pyridoxal phosphate-dependent enzyme, 1-aminocyclopropane-1-carboxylate synthase (ACS; EC 4.4.1.14), catalyzes the rate-limiting step in the ethylene biosynthetic pathway in plants. The Arabidopsis genome encodes nine ACS polypeptides that form eight functional (ACS2, ACS4-9, ACS11) and one nonfunctional (ACS1) ho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsuchisaka A,Theologis A

更新日期：2004-02-24 00:00:00

abstract：:The mitochondria are the major source of chronic oxidative stress, which has been implicated in the aging process. Along with other cellular changes, aged cells accumulate mutations in both their nuclear and mitochondrial genomes, and they contain increased amounts of oxidatively damaged mutagenic bases such as 7,8-di...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Szczesny B,Hazra TK,Papaconstantinou J,Mitra S,Boldogh I

更新日期：2003-09-16 00:00:00

abstract：:We recently have shown that mice deficient for the 86-kDa component (Ku80) of the DNA-dependent protein kinase exhibit growth retardation and a profound deficiency in V(D)J (variable, diversity, and joining) recombination. These defects may be related to abnormalities in DNA metabolism that arise from the inability of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nussenzweig A,Sokol K,Burgman P,Li L,Li GC

更新日期：1997-12-09 00:00:00