Developmental loss of miniature N-methyl-D-aspartate receptor currents in NR2A knockout mice.

abstract：:During mitochondrial ATP synthesis, F1-ATPase-the portion of the ATP synthase that contains the catalytic and regulatory nucleotide binding sites-undergoes a series of concerted conformational changes that couple proton translocation to the synthesis of the high levels of ATP required for cellular function. In the str...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bianchet MA,Hullihen J,Pedersen PL,Amzel LM

更新日期：1998-09-15 00:00:00

abstract：:The neonatal Fc receptor for IgG (FcRn) is a distant member of the MHC class I protein family. It binds IgG and albumin in a pH-dependent manner and protects these from catabolism by diverting them from a degradative fate in lysosomes. In addition, FcRn-mediated IgG transport across epithelial barriers is responsible ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qiao SW,Kobayashi K,Johansen FE,Sollid LM,Andersen JT,Milford E,Roopenian DC,Lencer WI,Blumberg RS

更新日期：2008-07-08 00:00:00

abstract：:Polymorphism in materials often leads to significantly different physical properties--the rutile and anatase polymorphs of TiO2 are a prime example. Polytypism is a special type of polymorphism, occurring in layered materials when the geometry of a repeating structural layer is maintained but the layer-stacking sequen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luo H,Xie W,Tao J,Inoue H,Gyenis A,Krizan JW,Yazdani A,Zhu Y,Cava RJ

更新日期：2015-03-17 00:00:00

abstract：:The radial distributions of the Calpha and side-chain atoms in a sample of 13 native proteins have been examined. It is found that there are substantial differences in behavior between different atoms of the same amino acid. In particular, the Calpha atoms of polar residues show no particular preference for being far ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rackovsky S,Scheraga HA

更新日期：1977-12-01 00:00:00

abstract：:Acute glaucoma is a sight-threatening condition characterized by a sudden and substantial rise in intraocular pressure (IOP) and consequent retinal ganglion cell (RGC) death. Angle closure glaucoma, a common cause of glaucoma in Asia that affects tens of millions of people worldwide, often presents acutely with loss o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chi W,Li F,Chen H,Wang Y,Zhu Y,Yang X,Zhu J,Wu F,Ouyang H,Ge J,Weinreb RN,Zhang K,Zhuo Y

更新日期：2014-07-29 00:00:00

abstract：:We have examined the role of cyclooxygenase 2 (COX-2) in a model of inflammation in vivo. Carrageenan administration to the subcutaneous rat air pouch induces a rapid inflammatory response characterized by high levels of prostaglandins (PGs) and leukotrienes in the fluid exudate. The time course of the induction of CO...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Masferrer JL,Zweifel BS,Manning PT,Hauser SD,Leahy KM,Smith WG,Isakson PC,Seibert K

更新日期：1994-04-12 00:00:00

abstract：:Gametocytes are nonreplicative sexual forms that mediate malaria transmission to a mosquito vector. They are generated from asexual blood-stage parasites that proliferate in the circulation. However, little is known about how this transition is genetically regulated. Here, we report that an Apetala2 (AP2) family trans...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yuda M,Iwanaga S,Kaneko I,Kato T

更新日期：2015-10-13 00:00:00

abstract：:An enzymatic activity, having the properties expected of a B-specific host-controlled modification enzyme, has been purified from an extract of Escherichia coli strain B. This activity renders the unmodified replicative form of phage fd resistant to B-specific restriction and is only present in strains carrying intact...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kühnlein U,Linn S,Arber W

更新日期：1969-06-01 00:00:00

abstract：:Unlike tailed bacteriophages, which use a preformed tail for transporting their genomes into a host bacterium, the ssDNA bacteriophage ΦX174 is tailless. Using cryo-electron microscopy and time-resolved small-angle X-ray scattering, we show that lipopolysaccharides (LPS) form bilayers that interact with ΦX174 at an ic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sun Y,Roznowski AP,Tokuda JM,Klose T,Mauney A,Pollack L,Fane BA,Rossmann MG

更新日期：2017-12-26 00:00:00

abstract：:One-electron oxidation of zinc tetraphenylbacteriochlorin and its metal-free base yielded stable cation radicals. Electron spin resonance hyperfine splittings were assigned by selective deuterations. These results indicate that the protons of the saturated rings of the bacteriochlorins carry large spin densities, in a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fajer J,Borg DC,Forman A,Felton RH,Dolphin D,Vegh L

更新日期：1974-03-01 00:00:00

abstract：:Practicing a motor skill triggers a process of memory consolidation that continues for hours after practice has ended, and becomes manifest in an improved skill at later testing. We used a sequential motor task (finger-to-thumb opposition task) to show that, in humans, the formation of motor skill memories essentially...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fischer S,Hallschmid M,Elsner AL,Born J

更新日期：2002-09-03 00:00:00

abstract：:Defining prospective pathways by which zoonoses evolve and emerge as human pathogens is critical for anticipating and controlling both natural and deliberate pandemics. However, predicting tenable pathways of animal-to-human movement has been hindered by challenges in identifying reservoir species, cultivating zoonoti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Becker MM,Graham RL,Donaldson EF,Rockx B,Sims AC,Sheahan T,Pickles RJ,Corti D,Johnston RE,Baric RS,Denison MR

更新日期：2008-12-16 00:00:00

abstract：:Classical studies suggest that high-level cognitive decisions (e.g., choosing between financial options) are suboptimal. In contrast, low-level decisions (e.g., choosing where to put your feet on a rocky ridge) appear near-optimal: the perception-cognition gap. Moreover, in classical tasks, people appear to put too mu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jarvstad A,Hahn U,Rushton SK,Warren PA

更新日期：2013-10-01 00:00:00

abstract：:We report here on the isolation and characterization of a serotonin (5HT) transporter from Drosophila melanogaster. A 3.1-kb complementary DNA clone (dSERT) was found to encode a protein of 622 amino acid residues with a predicted molecular mass of approximately 69 kDa and a putative transmembrane topology characteris...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Demchyshyn LL,Pristupa ZB,Sugamori KS,Barker EL,Blakely RD,Wolfgang WJ,Forte MA,Niznik HB

更新日期：1994-05-24 00:00:00

abstract：:A site has been found that is required for repression of the Escherichia coli araBAD operon. This site was detected by the in vivo properties of deletion mutants. In vitro protection studies with DNase I and dimethylsulfate showed that araC protein can specifically bind in this area to nucleotides lying at position -2...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dunn TM,Hahn S,Ogden S,Schleif RF

更新日期：1984-08-01 00:00:00

abstract：:Glycan-protein interactions are emerging as important modulators of membrane protein organization and dynamics, regulating multiple cellular functions. In particular, it has been postulated that glycan-mediated interactions regulate surface residence time of glycoproteins and endocytosis. How this precisely occurs is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Torreno-Pina JA,Castro BM,Manzo C,Buschow SI,Cambi A,Garcia-Parajo MF

更新日期：2014-07-29 00:00:00

abstract：:Visual transduction in Drosophila is a G protein-coupled phospholipase C-mediated process that leads to depolarization via activation of the transient receptor potential (TRP) calcium channel. Inactivation-no-afterpotential D (INAD) is an adaptor protein containing PDZ domains known to interact with TRP. Immunoprecipi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shieh BH,Zhu MY,Lee JK,Kelly IM,Bahiraei F

更新日期：1997-11-11 00:00:00

abstract：:Selection of aptamers from nucleic acid libraries by in vitro evolution represents a powerful method of identifying high-affinity ligands for a broad range of molecular targets. Nevertheless, a sizeable fraction of proteins remain difficult targets due to inherently limited chemical diversity of nucleic acids. We have...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Davies DR,Gelinas AD,Zhang C,Rohloff JC,Carter JD,O'Connell D,Waugh SM,Wolk SK,Mayfield WS,Burgin AB,Edwards TE,Stewart LJ,Gold L,Janjic N,Jarvis TC

更新日期：2012-12-04 00:00:00

abstract：:Canavan's disease (CD) is a fatal, hereditary disorder of CNS development that has been linked to mutations in the gene for the enzyme aspartoacylase (ASPA) (EC 3.5.1.15). ASPA acts to hydrolyze N-acetylaspartate (NAA) into l-aspartate and acetate, but the connection between ASPA deficiency and the failure of proper C...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Madhavarao CN,Arun P,Moffett JR,Szucs S,Surendran S,Matalon R,Garbern J,Hristova D,Johnson A,Jiang W,Namboodiri MA

更新日期：2005-04-05 00:00:00

abstract：:Converging TGF-beta and insulin-like neuroendocrine signaling pathways regulate whether Caenorhabditis elegans develops reproductively or arrests at the dauer larval stage. We examined whether neurotransmitters act in the dauer entry or recovery pathways. Muscarinic agonists promote recovery from dauer arrest induced ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tissenbaum HA,Hawdon J,Perregaux M,Hotez P,Guarente L,Ruvkun G

更新日期：2000-01-04 00:00:00

abstract：:The production of hybridomas between immunologically activated T cells and malignant T-cell lines offers a potentially unlimited source of soluble T-cell-derived products. Recently, human T-T hybrids have been described; however, their use has been hampered by slow growth and chromosomal instability due at least in pa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Foung SK,Sasaki DT,Grumet FC,Engleman EG

更新日期：1982-12-01 00:00:00

abstract：:To explore protein space from a global perspective, we consider 9,710 SCOP (Structural Classification of Proteins) domains with up to 70% sequence identity and present all similarities among them as networks: In the "domain network," nodes represent domains, and edges connect domains that share "motifs," i.e., signifi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nepomnyachiy S,Ben-Tal N,Kolodny R

更新日期：2014-08-12 00:00:00

abstract：:In vivo phage display identifies peptides that selectively home to the vasculature of individual organs, tissues, and tumors. Here we report the identification of a cyclic nonapeptide, CPGPEGAGC, which homes to normal breast tissue with a 100-fold selectivity over nontargeted phage. The homing of the phage is inhibite...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Essler M,Ruoslahti E

更新日期：2002-02-19 00:00:00

abstract：:There is controversy over the nature of the disturbance in brain development that underpins attention-deficit/hyperactivity disorder (ADHD). In particular, it is unclear whether the disorder results from a delay in brain maturation or whether it represents a complete deviation from the template of typical development....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shaw P,Eckstrand K,Sharp W,Blumenthal J,Lerch JP,Greenstein D,Clasen L,Evans A,Giedd J,Rapoport JL

更新日期：2007-12-04 00:00:00

abstract：:Many first-line cancer drugs are natural products or are derived from them by chemical modification. The trioxacarcins are an emerging class of molecules of microbial origin with potent antiproliferative effects, which may derive from their ability to covalently modify duplex DNA. All trioxacarcins appear to be deriva...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Švenda J,Hill N,Myers AG

更新日期：2011-04-26 00:00:00

abstract：:In vitro, polynucleotide phosphorylase of Escherichia coli can both synthesize RNA by using nucleotide diphosphates as precursors and exonucleolytically degrade RNA in the presence of inorganic phosphate. However, because of the high in vivo concentration of inorganic phosphate in exponentially growing cells, it has b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mohanty BK,Kushner SR

更新日期：2000-10-24 00:00:00

abstract：:Human activities have increased N availability dramatically in terrestrial and aquatic ecosystems. Extensive research demonstrates that local plant species diversity generally declines in response to nutrient enrichment, yet the mechanisms for this decline remain unclear. Based on an analysis of >900 species responses...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Suding KN,Collins SL,Gough L,Clark C,Cleland EE,Gross KL,Milchunas DG,Pennings S

更新日期：2005-03-22 00:00:00

abstract：:Previous work indicated that the light chains of a monotypic immunoglobulins G2-K and M-K from a single patient (Ti1) are identical. Our present data show that the monotypic immunoglobulins G and M share idiotypic determinants not present in their isolated light chains or in any of a large number of other immunoglobul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang AC,Wilson KS,Hopper JE,Fudenberg HH,Nisonoff A

更新日期：1970-06-01 00:00:00

abstract：:Time courses of 13C labeling from alanine and ethanol in perfused mouse livers have been followed by NMR. The enrichment at specific carbons of glucose, glutamate, glutamine, aspartate, acetate, acetoacetate, beta-hydroxybutyrate, and lactate has been measured. The specific labeling of glutamate in the presence of lab...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cohen SM,Shulman RG,McLaughlin AC

更新日期：1979-10-01 00:00:00

abstract：:Short oxygen-halogen interactions have been known in organic chemistry since the 1950s and recently have been exploited in the design of supramolecular assemblies. The present survey of protein and nucleic acid structures reveals similar halogen bonds as potentially stabilizing inter- and intramolecular interactions t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Auffinger P,Hays FA,Westhof E,Ho PS

更新日期：2004-11-30 00:00:00