Abstract:
:The ultimate destiny of a cell to undergo division, differentiation, survival, and death results from an intricate balance between multiple regulators including oncogenes, tumor suppressor genes, and cell cycle associated proteins. Deregulation of the cell cycle machinery switches the phenotype from a normal cell to a cancerous cell. Fundamental alterations of tumor suppressor genes may result in an unregulated cell cycle with the accumulation of mutations and eventual neoplastic transformation. As such, one may define cancer as a genetic disease of the cell cycle. In this review, we will emphasize our current understanding of how the cell cycle machinery maintains cellular homeostasis by studying the consequences of its deregulation.
journal_name
J Cell Physioljournal_title
Journal of cellular physiologyauthors
Tonini T,Hillson C,Claudio PPdoi
10.1002/jcp.10117keywords:
subject
Has Abstractpub_date
2002-08-01 00:00:00pages
138-50issue
2eissn
0021-9541issn
1097-4652journal_volume
192pub_type
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