Abstract:
:The Schneider membrane is the mucosa that covers the inner part of the maxillary sinus cavities. The free surface is a ciliated pseudostratified epithelium, while the deeper portion is a highly vascularized connective tissue. The stromal fraction, bordering the bony wall of the sinus, after tooth loss can exhibit increased osteoclastic activity resulting in resorption of the bone in the posterior maxilla. Goal of our study was to isolate and characterize mesenchymal progenitors in the Schneider's membrane connective net and to evaluate their self ability to differentiate toward osteoblastic lineage, in absence of osteoinductive factors and osteoconductive biomaterials of support. This should indicate that maxillary sinus membrane represents an useful an approachable source of MSCs for bone tissue engineering and cell therapy and owns the intrinsic capacity to restore maxillary bone after tooth loss without the needing of biomaterials.
journal_name
J Cell Physioljournal_title
Journal of cellular physiologyauthors
Graziano A,Benedetti L,Massei G,Cusella de Angelis MG,Ferrarotti F,Aimetti Mdoi
10.1002/jcp.24022subject
Has Abstractpub_date
2012-09-01 00:00:00pages
3278-81issue
9eissn
0021-9541issn
1097-4652journal_volume
227pub_type
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