Natural vegetable fats in the prevention of irritant contact dermatitis.

Abstract:

:Chronic irritant contact dermatitis (ICD) is one of the most pressing problems in occupational medicine and is common in the food processing industry. To date, protective creams that fulfil the special requirements in the foodstuffs industry have not been available. Therefore, we studied the efficacy of pre-exposure application of natural vegetable fats in the prevention of experimentally induced ICD. A panel of 20 healthy volunteers was tested with a repetitive irritation test using sodium lauryl sulfate (SLS) as a standard irritant in a randomized study. Application sites were assessed clinically and by the use of bioengineering techniques (evaporimetry, chromametry, and corneometry). Rape seed and palm fats showed significant protective potential. Gas-chromatographic analysis revealed differences in the fatty acid composition of the vegetable. Higher content of linoleic acid and lower content of oleic acid was associated with beneficial effects. Our results are a new approach in the prevention of ICD and towards the development of new protective preparations for workplaces in the foodstuffs industry.

journal_name

Contact Dermatitis

journal_title

Contact dermatitis

authors

Schliemann-Willers S,Wigger-Alberti W,Kleesz P,Grieshaber R,Elsner P

doi

10.1034/j.1600-0536.2002.460102.x

keywords:

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

6-12

issue

1

eissn

0105-1873

issn

1600-0536

pii

cod460102

journal_volume

46

pub_type

临床试验,杂志文章,随机对照试验
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