Cross-reactivity between sensitivity to thimerosal and photosensitivity to piroxicam in guinea pigs.

Abstract:

:Piroxicam (PXM) is a nonsteroidal anti-inflammatory drug which may induce a photosensitive eruption shortly after administration. We examined whether animals sensitized to thimerosal developed a photosensitivity to PXM. Male Hartley strain guinea pigs were sensitized to thimerosal, thiosalicylate and PXM separately. The open patch test was used to evaluate sensitization to each drug and cross-reactions between the drugs. Animals sensitized to thimerosal exhibited positive patch test reactions to thiosalicylate and positive photopatch test reactions to PXM. Both those sensitized to thiosalicylate and to PXM showed positive patch test reactions to PXM. This study demonstrated that thimerosal induces cross-sensitivity to PXM in vivo and that the common active component among these compounds may be thiosalicylate.

journal_name

Contact Dermatitis

journal_title

Contact dermatitis

authors

Kitamura K,Osawa J,Ikezawa Z,Nakajima H

doi

10.1111/j.1600-0536.1991.tb01769.x

subject

Has Abstract

pub_date

1991-07-01 00:00:00

pages

30-4

issue

1

eissn

0105-1873

issn

1600-0536

journal_volume

25

pub_type

杂志文章
  • Effect of test techniques of perfusion of neomycin sulfate patch tests. A comparative study with visual assessments.

    abstract::Effects of test techniques on neomycin patch test results have not been thoroughly investigated. This study focuses on effects of dose and application time of neomycin sulfate patch tests on test results. The effects are assessed both visually and by perfusion. 16 subjects positive to neomycin are retested with neomyc...

    journal_title:Contact dermatitis

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1034/j.1600-0536.2000.043005283.x

    authors: Bjarnason B,Flosadóttir E

    更新日期:2000-11-01 00:00:00

  • Higher allergenicity of high molecular weight hydrolysed wheat protein in cosmetics for percutaneous sensitization.

    abstract:BACKGROUND:Wheat protein derivatives are used in a variety of products worldwide. Gluten is commercially used 'as is' or with modifications such as hydrolysis, which is carried out to overcome its insolubility. Several cases of contact urticaria following exposure to hydrolysed wheat protein (HWP) in cosmetics or of an...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.2012.02168.x

    authors: Chinuki Y,Takahashi H,Dekio I,Kaneko S,Tokuda R,Nagao M,Fujisawa T,Morita E

    更新日期:2013-02-01 00:00:00

  • Patch testing with substances not included in the standard series.

    abstract::During a 5-year period, 3664 consecutive patients were patch tested in a private dermatology practice with the Standard Series of the International Contact Dermatitis Research Group (ICDRG). 454 of these were tested with one or more additional substances which were suspected of having caused their dermatitis. 194 of t...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.1983.tb04396.x

    authors: Veien NK,Hattel T,Justesen O,Nørholm A

    更新日期:1983-07-01 00:00:00

  • Patch test reactions to Biobans in metalworkers are often weak and not reproducible.

    abstract::Contact allergy to the industrial preservative group of Biobans has been reported in individual cases. We have performed a prospective study on 408 metalworkers who were tested with 6 different Biobans, formaldehyde and 5 other preservatives. Furthermore, retesting was performed after a time interval of 6 months to 4 ...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1034/j.1600-0536.2002.470106.x

    authors: Brinkmeier T,Geier J,Lepoittevin JP,Frosch PJ

    更新日期:2002-07-01 00:00:00

  • Sensitization potential of benzotriazole.

    abstract::Predictive guinea pig sensitization studies have been performed with commercial and purified 1H-benzotriazole. In only 3 animals, induced and challenged according to the maximization protocol with more than 100 times the normal use concentration, were slight erythemas elicited with the commercial grade of benzotriazol...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.1984.tb00024.x

    authors: Maurer T,Meier F

    更新日期:1984-03-01 00:00:00

  • A comparison of expression of surface-bound immunoglobulin E on antigen-presenting cells in cutaneous tissue between patients with allergic, irritant and atopic dermatitis.

    abstract::The expression of surface-bound immunoglobulin E by dendritic cells within cutaneous tissue has been compared in atopic and contact dermatitis. 45 patients were recruited into 4 groups using clinical criteria and patch testing to a standard series of allergens: atopic (12 cases), allergic contact dermatitis (14 cases)...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.1991.tb01799.x

    authors: Ward KA,Todd D,Thornton C,Walsh M,Burrows D

    更新日期:1991-08-01 00:00:00

  • Prevalence of foot eczema and associated occupational and non-occupational factors in patients with hand eczema.

    abstract:BACKGROUND:Foot eczema often occurs in combination with hand eczema. However, in contrast to the situation with hand eczema, knowledge about foot eczema is scarce, especially in occupational settings. OBJECTIVE:To evaluate the prevalence of foot eczema and associated factors in patients with hand eczema taking part in...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/cod.12370

    authors: Brans R,Hübner A,Gediga G,John SM

    更新日期:2015-08-01 00:00:00

  • Guinea pig maximization test of the bark extract from pawpaw, Asimina triloba (Annonaceae).

    abstract::Several acetogenins, characteristic of the Annonaceae, have been found to exhibit pesticidal and feeding-deterrent activities against a variety of pests and are undergoing commercial development as pesticides. The sensitizing potential of one of these plants, pawpaw, Asimina triloba Dunal, was examined in the current ...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.1993.tb04533.x

    authors: Avalos J,Rupprecht JK,McLaughlin JL,Rodriguez E

    更新日期:1993-07-01 00:00:00

  • Formaldehyde is a significant allergen in women with hand eczema.

    abstract::Among patients consecutively patch tested at St John's from 1984-1989, the prevalence rate of formaldehyde sensitivity was 2.2% for men and 3.7% for women. During these 6 years, 117 women were primarily sensitized by formaldehyde, of whom 61 (52%) had hand eczema. Exposure was occupational in 12% and domestic in 88%. ...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.1991.tb01874.x

    authors: Cronin E

    更新日期:1991-11-01 00:00:00

  • Frequency of sensitization to 13 common preservatives in Switzerland. Swiss Contact Dermatitis Research Group.

    abstract::From February 1989 to January 1990, the Swiss Contact Dermatitis Research Group conducted a 1-year study to examine the frequency of sensitization to a series of 13 common preservatives. A group of 2295 consecutive outpatients with suspected allergic contact dermatitis (age range 7-90 years, with a mean age of 42; 911...

    journal_title:Contact dermatitis

    pub_type: 杂志文章,多中心研究,评审

    doi:10.1111/j.1600-0536.1994.tb00597.x

    authors: Perrenoud D,Bircher A,Hunziker T,Suter H,Bruckner-Tuderman L,Stäger J,Thürlimann W,Schmid P,Suard A,Hunziker N

    更新日期:1994-05-01 00:00:00

  • Delayed hypersensitivity drug reactions diagnosed by patch testing.

    abstract::Drug reactions are a common problem in hospital inpatients and outpatients. Oral or parenteral drug challenges are valuable diagnostic aids, but time consuming. We review attempts to diagnose delayed hypersensitivity drug eruptions by patch testing. We review control data, and offer an operational definition that migh...

    journal_title:Contact dermatitis

    pub_type: 杂志文章,评审

    doi:10.1111/j.1600-0536.1993.tb03555.x

    authors: Calkin JM,Maibach HI

    更新日期:1993-11-01 00:00:00

  • Concurrent sensitization to metals and occupation.

    abstract:BACKGROUND:Cosensitization to nickel, cobalt and chromium occurs in the general population and in some occupational groups. OBJECTIVES:To estimate the isolated and concurrent occurrence of nickel, cobalt and chromium contact sensitization and their association with individual and occupational risk factors. PATIENTS/M...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.2012.02100.x

    authors: Rui F,Bovenzi M,Prodi A,Fortina AB,Romano I,Corradin MT,Filon FL

    更新日期:2012-12-01 00:00:00

  • Patch testing with a mixture of 2 phenol-formaldehyde resins.

    abstract::1310 patients were routinely patch tested with a paratertiary-butylphenol-formaldehyde resin (PTBP-F-R), a resol resin based on phenol and formaldehyde (P-F-R-2), and a mixture of these 2 resins. Approximately 2.5 times more patients with contact allergy to phenol-formaldehyde resins were diagnosed when routinely patc...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.1988.tb05507.x

    authors: Bruze M

    更新日期:1988-08-01 00:00:00

  • Patch testing and sensitization to multiple drugs.

    abstract:BACKGROUND:Adverse drug reactions pose an increasing diagnostic challenge in hospitals and in outpatient clinics. When consecutive or repeated allergic drug eruptions are suspected, patch testing is a useful diagnostic tool for determining the causative drugs. OBJECTIVES:The aim of the study was to identify patient ca...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/cod.12076

    authors: Liippo J,Pummi K,Hohenthal U,Lammintausta K

    更新日期:2013-11-01 00:00:00

  • Nickel contact allergy and menstrual cycle.

    abstract::According to some reports in the literature, the hormonal fluctuations which occur during the menstrual cycle may affect the clinical expression of contact allergy to a greater or lesser degree. In clinical practice, too, patient history often shows exacerbation of the contact dermatitis during the days immediately pr...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.0105-1873.2005.00588.x

    authors: Bonamonte D,Foti C,Antelmi AR,Biscozzi AM,Naro ED,Fanelli M,Loverro G,Angelini G

    更新日期:2005-06-01 00:00:00

  • Contamination by nickel, copper and zinc during the handling of euro coins.

    abstract::The introduction of the euro has revived interest in the risk of nickel allergy due to the handling of coins. In the present work, the transfer of metallic contamination during the manipulation of coins is examined by means of leaching experiments and manipulation tests. It is shown that pre-existing metallic species ...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1034/j.1600-0536.2003.00028.x

    authors: Fournier PG,Govers TR

    更新日期:2003-04-01 00:00:00

  • An epidemic of allergic contact dermatitis caused by a new allergen, caprylhydroxamic acid, in moisturizers.

    abstract:BACKGROUND:In 2016, dermatologists in Finland suspected contact allergy in several patients using moisturizers under the trade name Apobase®. Following a formulation change, Phenostat™, which is a mixture of phenoxyethanol, caprylhydroxamic acid, and methylpropanediol, was used as a preservative in Apobase® moisturizer...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/cod.12787

    authors: Ackermann L,Virtanen H,Korhonen L,Laukkanen A,Huilaja L,Riekki R,Hasan T

    更新日期:2017-09-01 00:00:00

  • Laser Doppler perfusion imaging for the documentation of flare-up in contact allergy to gold.

    abstract::A healed or healing allergic contact dermatitis is easily reactivated to a flare-up if the patient is provoked systemically with his particular allergen. 5 patients with contact allergy to gold were patch tested with a serial dilution of gold sodium thiosulfate. 1 to 2 months later, when positive test reactions were h...

    journal_title:Contact dermatitis

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1600-0536.1999.tb06103.x

    authors: Möller H,Björkner B,Bruze M,Lundqvist K,Wollmer P

    更新日期:1999-09-01 00:00:00

  • Late skin reaction to iodixanol (Visipaque): clinical manifestations, patch test study, and histopathological evaluation.

    abstract::Late reactions to iodinated contrast media are frequent. Cutaneous manifestations are the commonest, in which maculopapular exanthema, a type of cutaneous presentation, is widespread. Controversy exists about the utility of the skin test in the management of these reactions. The aim of this study is to analyse the cli...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.2006.00957.x

    authors: Delgado-Jimenez Y,Perez-Gala S,Aragüés M,Sanchez-Perez J,Garcia-Diez A

    更新日期:2006-12-01 00:00:00

  • Sensitization to olive oil (olea europeae).

    abstract::Sensitization to olive oil is seldom reported in the literature. By use of epicutaneous tests a delayed type of hypersensitivity to pure freshly-prepared olive oil could be demonstrated in two patients. Patch tests with certain major constituents of olive oil; the methyl ester of linoleic acid, the glyceryl ester of p...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.1981.tb04086.x

    authors: van Joost T,Smitt JH,van Ketel WG

    更新日期:1981-11-01 00:00:00

  • Oral challenge with metal salts. (I). Vesicular patch-test-negative hand eczema.

    abstract::202 patients, 68 males and 134 females, with patch-test-negative, symmetrical vesicular hand eczema were challenged orally in a controlled study with 2.5 mg nickel, 2.5 mg chromium and 1 mg cobalt given as salts of the respective metals. Initially a mixture of the 3 metal salts was given, and if this produced a flare ...

    journal_title:Contact dermatitis

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1600-0536.1983.tb04437.x

    authors: Veien NK,Hattel T,Justesen O,Nørholm A

    更新日期:1983-09-01 00:00:00

  • Ethnic variation in the skin irritation response.

    abstract::There is a widespread, but largely unsubstantiated, view that certain skin types may be more susceptible to the effect of skin irritants than others. One expression of this would be that certain ethnic groups may also be more likely to experience skin irritation. As a consequence, when evaluating the skin compatibilit...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1034/j.1600-0536.2001.450605.x

    authors: Foy V,Weinkauf R,Whittle E,Basketter DA

    更新日期:2001-12-01 00:00:00

  • Bacteria and soluble oil dermatitis.

    abstract::Simultaneous investigation of the bacterial flora of a soluble oil in use as a metalworking fluid and of the skin of machine operatives exposed to that soluble oil did not support the hypothesis that bacteria in soluble oil emulsions colonise the skin and either initiate or maintain the dermatitis associated with solu...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.1980.tb03873.x

    authors: Rycroft RJ

    更新日期:1980-01-01 00:00:00

  • Skin irritant reactivity following experimental cumulative irritant contact dermatitis.

    abstract::Despite the frequency of irritant contact dermatitis, very little is known about the duration of barrier function impairment following cumulative irritant contact dermatitis. We studied post-irritation irritant reactivity by assessing the response to SLS irritation in previously irritated sites. Cumulative irritant co...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.1994.tb00725.x

    authors: Widmer J,Elsner P,Burg G

    更新日期:1994-01-01 00:00:00

  • Contact dermatitis. A review.

    abstract::In recent years, there has been a dramatic rise in our understanding of contact dermatitis. This paper is a review of our knowledge of the mechanisms involved in contact dermatitis and related phenomena, the investigation of these events and the emergence of significant new allergens during the last 5 years. ...

    journal_title:Contact dermatitis

    pub_type: 杂志文章,评审

    doi:10.1111/j.1600-0536.1987.tb01382.x

    authors: Andersen KE,Benezra C,Burrows D,Camarasa J,Dooms-Goossens A,Ducombs G,Frosch P,Lachapelle JM,Lahti A,Menné T

    更新日期:1987-02-01 00:00:00

  • Hand eczema in a prospectively-followed cohort of office-workers.

    abstract::A cohort of initially 111 office apprentices was prospectively followed for the duration of their training (2 and 3 years, respectively). The point prevalence of (slight) irritant or atopic hand eczema was 18.9% in the initial and 25.0% in the final examinations. Altogether, 37 cases of (slight) hand eczema were noted...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:

    authors: Uter W,Pfahlberg A,Gefeller O,Schwanitz HJ

    更新日期:1998-02-01 00:00:00

  • Chlorothalonil, a possible cause of erythema dyschromicum perstans (ashy dermatitis).

    abstract::We studied 39 patients with erythema-dyschromicum-perstans-like dermatitis seen at Changuinola Hospital in Panama. They were compared with 41 controls. The 2 groups were native field workers of the banana plantations exposed to many pesticides. In 34 patients, there was a positive patch test reaction to 2,4,5,6-1,3-te...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.1996.tb02360.x

    authors: Penagos H,Jimenez V,Fallas V,O'Malley M,Maibach HI

    更新日期:1996-10-01 00:00:00

  • Cobalt release and complications resulting from the use of dental prostheses.

    abstract:BACKGROUND:Cobalt release from dental prostheses has been shown to elicit allergic reactions in cobalt-allergic patients. It is therefore important to investigate whether these prostheses are possible sources of sensitization. OBJECTIVES:To assess (i) cobalt release from dental prostheses and (ii) allergic reactions t...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/cod.12649

    authors: Al-Imam H,Benetti AR,Özhayat EB,Pedersen AM,Johansen JD,Thyssen JP,Jellesen MS,Gotfredsen K

    更新日期:2016-12-01 00:00:00

  • Pustular reactions to hexafluorosilicate in foam rubber.

    abstract::A case is reported of a foam rubber carrier with pustular lesions on the arms, wrists, thighs and trunk. Scratch and patch testing with the foam rubber components was negative. Animal testing revealed sodium hexafluorosilicate (Na2SiF6), one of the ingredients of the foam rubber, to be a pustulogen on previously damag...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.1985.tb01038.x

    authors: Dooms-Goossens A,Loncke J,Michiels JL,Degreef H,Wahlberg J

    更新日期:1985-01-01 00:00:00

  • Epidemiological, clinical and allergological observations on pompholyx.

    abstract::We have studied a group of 104 patients with pompholyx, to investigate the relationship between allergological factors and its etiopathogenesis. The following examinations were performed: blood sampling (routine tests and IgE levels), allergological tests (patch, prick, intradermal, and oral provovation tests with nic...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.1992.tb00862.x

    authors: Lodi A,Betti R,Chiarelli G,Urbani CE,Crosti C

    更新日期:1992-01-01 00:00:00