Gene therapy--when a simple concept meets a complex reality. Review on gene therapy.

abstract：:The IbeA (ibe10) gene is an invasion determinant contributing to E. coli K1 invasion of the blood-brain barrier. This gene has been cloned and characterized from the chromosome of an invasive cerebrospinal fluid isolate of E. coli K1, strain RS218 (018:K1: H7). In the present study, a genetic island of meningitic E. c...

journal_title：Functional & integrative genomics

authors： Huang SH,Chen YH,Kong G,Chen SH,Besemer J,Borodovsky M,Jong A

更新日期：2001-09-01 00:00:00

abstract：:Fungal species are potential dye decomposers since these secrete spectra of extracellular enzymes involved in catabolism. However, cellular mechanisms underlying azo dye catalysis and detoxification are incompletely understood and obscure. A potential strain designated as Penicillium oxalicum SAR-3 demonstrated broad-...

journal_title：Functional & integrative genomics

authors： Saroj S,Kumar K,Prasad M,Singh RP

更新日期：2014-12-01 00:00:00

abstract：:Cotton (Gossypium spp.) is an imperative economic crop of the globe due to its natural textile fiber. Molecular mechanisms of fiber development have been greatly revealed in allotetraploid cotton but remained unexplored in Gossypium herbaceum. G. herbaceum can withstand the rigors of nature like drought and pests but ...

journal_title：Functional & integrative genomics

authors： Parekh MJ,Kumar S,Fougat RS,Zala HN,Pandit RJ

更新日期：2018-03-01 00:00:00

abstract：:GRAS domain genes are a group of important plant-specific transcription factors that have been reported to be involved in plant development. In order to know the roles of GRAS genes in grapevine, a widely cultivated fruit crop, the study on grapevine GRAS (VvGRAS) was carried out, and from which, 43 were identified fr...

journal_title：Functional & integrative genomics

authors： Sun X,Xie Z,Zhang C,Mu Q,Wu W,Wang B,Fang J

更新日期：2016-07-01 00:00:00

abstract：:The symbiotic N(2)-fixing alpha-proteobacterium Sinorhizobium meliloti has three replicons: a circular chromosome (3.7 Mb) and two smaller replicons, pSymA (1.4 Mb) and pSymB (1.7 Mb). Sequence analysis has revealed that an essential gene is carried on pSymB, which brings into question whether pSymB should be consider...

journal_title：Functional & integrative genomics

authors： Wong K,Finan TM,Golding GB

更新日期：2002-11-01 00:00:00

abstract：:Auxin response factors (ARFs) are recently discovered transcription factors that bind with auxin response elements (AuxRE, TGTCTC) to regulate the expression of early auxin-responsive genes. To our knowledge, the ARF gene family has never been characterized in cotton, the most important fiber crop in the world. In thi...

journal_title：Functional & integrative genomics

authors： Sun R,Wang K,Guo T,Jones DC,Cobb J,Zhang B,Wang Q

更新日期：2015-07-01 00:00:00

abstract：:The proneness of diseases and susceptibility towards drugs vary from person to person. At present, there is a strong demand for the personalization of drugs. The genetic signature behind proneness of the disease has been studied through a comprehensive 'octopodial approach'. All the genetic variants included in the ap...

journal_title：Functional & integrative genomics

authors： Iyer PM,Karthikeyan S,Sanjay Kumar P,Krishnan Namboori PK

更新日期：2017-07-01 00:00:00

abstract：:Genomic structural variation is an important and abundant source of genetic and phenotypic variation. We previously reported an initial analysis of copy number variations (CNVs) in Angus cattle selected for resistance or susceptibility to gastrointestinal nematodes. In this study, we performed a large-scale analysis o...

journal_title：Functional & integrative genomics

authors： Hou Y,Liu GE,Bickhart DM,Matukumalli LK,Li C,Song J,Gasbarre LC,Van Tassell CP,Sonstegard TS

更新日期：2012-03-01 00:00:00

abstract：:The ever-rising population of the twenty-first century together with the prevailing challenges, such as deteriorating quality of arable land and water, has placed a big challenge for plant breeders to satisfy human needs for food under erratic weather patterns. Rice, wheat, and maize are the major staple crops consume...

journal_title：Functional & integrative genomics

authors： Choudhary M,Wani SH,Kumar P,Bagaria PK,Rakshit S,Roorkiwal M,Varshney RK

更新日期：2019-09-01 00:00:00

abstract：:Abiotic stress tolerance is a complex trait regulated by multiple genes and gene networks in plants. A range of abiotic stresses are known to limit rice productivity. Meta-transcriptomics has emerged as a powerful approach to decipher stress-associated molecular network in model crops. However, retaining specificity o...

journal_title：Functional & integrative genomics

authors： Smita S,Katiyar A,Lenka SK,Dalal M,Kumar A,Mahtha SK,Yadav G,Chinnusamy V,Pandey DM,Bansal KC

更新日期：2020-01-01 00:00:00

abstract：:In silico analysis together with cloning, molecular characterization and heterologous expression reports that the hypothetical protein All5371 of Anabaena sp. PCC7120 is a novel hydroperoxide scavenging protein similar to AhpD of bacteria. The presence of E(X)11CX HC(X)3H motif in All5371 confers peroxidase activity a...

journal_title：Functional & integrative genomics

authors： Shrivastava AK,Singh S,Singh PK,Pandey S,Rai LC

更新日期：2015-01-01 00:00:00

abstract：:The ubiquitous cell membrane proteins called aquaporins are now firmly established as channel proteins that control the specific transport of water molecules across cell membranes in all living organisms. The aquaporins are thus likely to be of fundamental significance to all facets of plant growth and development aff...

journal_title：Functional & integrative genomics

authors： Forrest KL,Bhave M

更新日期：2007-10-01 00:00:00

abstract：:Rhizoctonia solani AG1-IA is a soil-borne necrotrophic pathogen that causes devastating rice sheath blight disease in rice-growing regions worldwide. Sclerotia play an important role in the life cycle of R. solani AG1-IA. In this study, RNA sequencing was used to investigate the transcriptomic dynamics of sclerotial d...

journal_title：Functional & integrative genomics

authors： Shu C,Zhao M,Anderson JP,Garg G,Singh KB,Zheng W,Wang C,Yang M,Zhou E

更新日期：2019-09-01 00:00:00

abstract：:In the past decade, there has been an intense effort to comprehensively catalogue the expressed genes in the yeast Saccharomyces cerevisiae and to determine the absolute and relative abundance of transcript and protein levels under different cellular conditions. Several methods have been developed to monitor gene expr...

journal_title：Functional & integrative genomics

authors： Horak CE,Snyder M

更新日期：2002-09-01 00:00:00

abstract：:Medicago sativa L. (alfalfa) 'Zhaodong' is an important forage legume that can safely survive in northern China where winter temperatures reach as low as -30 °C. Survival of alfalfa following freezing stress depends on the amount and revival ability of crown buds. In order to investigate the molecular mechanisms of fr...

journal_title：Functional & integrative genomics

authors： Song L,Jiang L,Chen Y,Shu Y,Bai Y,Guo C

更新日期：2016-09-01 00:00:00

abstract：:Culex pipiens mosquitoes are important disease vectors inhabiting temperate zones, worldwide. The seasonal reduction in temperature and photoperiod accompanying late summer and early fall prompts female mosquitoes to enter diapause, a stage of developmental arrest and physiological conditioning that enhances survival ...

journal_title：Functional & integrative genomics

authors： Hickner PV,Mori A,Zeng E,Tan JC,Severson DW

更新日期：2015-07-01 00:00:00

abstract：:GDSL-type esterase/lipase (GELP) is mainly characterized by a conserved GDSL domain at N terminus, and is widely found in all living species, both prokaryotes and eukaryotes. GELP gene family consists of a wide range of members playing important roles in plant physiological processes, such as development, stress respo...

journal_title：Functional & integrative genomics

authors： Cao Y,Han Y,Meng D,Abdullah M,Yu J,Li D,Jin Q,Lin Y,Cai Y

更新日期：2018-11-01 00:00:00

abstract：:Drought is a major abiotic stress affecting crop productivity and quality. As a class of noncoding RNA, microRNA (miRNA) plays important roles in plant growth, development, and stress response. However, their response and roles in tomato drought stress is largely unknown. Here, by using high-throughput sequencing, we ...

journal_title：Functional & integrative genomics

authors： Liu M,Yu H,Zhao G,Huang Q,Lu Y,Ouyang B

更新日期：2018-01-01 00:00:00

abstract：:Campylobacter jejuni remains a major cause of human gastroenteritis with estimated annual incidence rate of 450 million infections worldwide. C. jejuni is a major burden to public health in both socioeconomically developing and industrialized nations. Virulence determinants involved in C. jejuni pathogenesis are multi...

journal_title：Functional & integrative genomics

authors： Mehla K,Ramana J

更新日期：2017-01-01 00:00:00

abstract：:Natural selection drives species adaptations to biotic and abiotic stresses. Species distributed along a moisture gradient, such as Stipa purpurea, a dominant grass in alpine arid and semi-arid meadows on the Tibetan Plateau, provide an opportunity to evaluate the effects of long-term adaptation to differing degrees o...

journal_title：Functional & integrative genomics

authors： Yang Y,Li X,Kong X,Ma L,Hu X,Yang Y

更新日期：2015-05-01 00:00:00

abstract：:The oomycete pathogen Plasmopara viticola (Berk. et Curt.) Berl. et de Toni is the causing agent of the destructive downy mildew disease in grapevine. Despite the advances towards elucidation of grapevine resistance mechanisms to downy mildew, increased knowledge of the biological and genetic components of the pathosy...

journal_title：Functional & integrative genomics

authors： Figueiredo A,Monteiro F,Fortes AM,Bonow-Rex M,Zyprian E,Sousa L,Pais MS

更新日期：2012-06-01 00:00:00

abstract：:A cDNA library containing approximately 5,000 clones from germinating barley embryos was constructed and used to examine the variation in gene expression patterns during the first 4 days postimbibition. The expression profiles of embryos (including scutellum) from 4 to 96 h postimbibition were compared to a reference ...

journal_title：Functional & integrative genomics

authors： Watson L,Henry RJ

更新日期：2005-07-01 00:00:00

abstract：:The response of a grass halophyte Spartina alterniflora at early stages of salt stress was investigated through generation and systematic analysis of expressed sequence tags (ESTs) from both leaf and root tissues. Random EST sequencing produced 1,227 quality ESTs, which were clustered into 127 contigs, and 368 were si...

journal_title：Functional & integrative genomics

authors： Baisakh N,Subudhi PK,Varadwaj P

更新日期：2008-08-01 00:00:00

abstract：:Intronless genes, a characteristic feature of prokaryotes, constitute a significant portion of the eukaryotic genomes. Our analysis revealed the presence of 11,109 (19.9%) and 5,846 (21.7%) intronless genes in rice and Arabidopsis genomes, respectively, belonging to different cellular role and gene ontology categories...

journal_title：Functional & integrative genomics

authors： Jain M,Khurana P,Tyagi AK,Khurana JP

更新日期：2008-02-01 00:00:00

abstract：:The whole genome expression pattern of Arabidopsis in response to the auxinic herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) was evaluated using the Affymetrix ATH1-121501 array. Arabidopsis plants were grown in vitro and were exposed to 1 mM 2,4-D for 1 h, after which time gene transcription levels were measured. I...

journal_title：Functional & integrative genomics

authors： Raghavan C,Ong EK,Dalling MJ,Stevenson TW

更新日期：2005-01-01 00:00:00

abstract：:In grapes (Vitis vinifera L.), exogenous gibberellic acid (GA3) is applied at different stages of bunch development to achieve desirable bunch shape and berry size in seedless grapes used for table purpose. RNA sequence-based transcriptome analysis was used to understand the mechanism of GA3 action at cluster emergenc...

journal_title：Functional & integrative genomics

authors： Upadhyay A,Maske S,Jogaiah S,Kadoo NY,Gupta VS

更新日期：2018-07-01 00:00:00

abstract：:Nuclear genomes of human, animals, and plants are organized into subunits called chromosomes. When isolated into aqueous suspension, mitotic chromosomes can be classified using flow cytometry according to light scatter and fluorescence parameters. Chromosomes of interest can be purified by flow sorting if they can be ...

journal_title：Functional & integrative genomics

authors： Doležel J,Vrána J,Safář J,Bartoš J,Kubaláková M,Simková H

更新日期：2012-08-01 00:00:00

abstract：:Carefully analyzed expression profiles can serve as a valuable reference for deciphering gene functions. We exploited the potential of whole genome microarrays to measure the spatial and temporal expression profiles of rice genes in 19 stages of vegetative and reproductive development. We could verify expression of 22...

journal_title：Functional & integrative genomics

authors： Sharma R,Agarwal P,Ray S,Deveshwar P,Sharma P,Sharma N,Nijhawan A,Jain M,Singh AK,Singh VP,Khurana JP,Tyagi AK,Kapoor S

更新日期：2012-06-01 00:00:00

abstract：:The assembly of a 1.3-Mb size region of the wheat genome has provided the opportunity to study a recent nuclear mitochondrial DNA insertion (NUMT). In the present study, we have studied two bacterial artificial chromosomes (BACs) and characterized a 52-kb NUMT segment from the tetraploid and hexaploid wheat BAC librar...

journal_title：Functional & integrative genomics

authors： Zhang J,Jia J,Breen J,Kong X

更新日期：2011-12-01 00:00:00

abstract：:EST-derived microsatellites or simple sequence repeats (eSSR) occur in expressed sequence tags (EST). Here we report characteristics of eSSRs in the wheat genome, construction of consensus chromosome bin maps of SSR-containing ESTs ((SSR)ESTs), and development of eSSR markers for the 21 wheat chromosomes. A Perl scrip...

journal_title：Functional & integrative genomics

authors： Peng JH,Lapitan NL

更新日期：2005-04-01 00:00:00