Abstract:
:In the past decade, there has been an intense effort to comprehensively catalogue the expressed genes in the yeast Saccharomyces cerevisiae and to determine the absolute and relative abundance of transcript and protein levels under different cellular conditions. Several methods have been developed to monitor gene expression: DNA microarray analysis, Serial Analysis of Gene Expression (SAGE), kinetic RT-PCR and monitoring expression of beta-galactosidase fusion proteins. These techniques have been used to measure transcript and protein abundance in different developmental states and under different environmental stimuli. A wealth of expression data for yeast is now publicly available through several web sites. The expression information that exists has the obvious benefits of providing a better understanding of the gene expression patterns that accompany changes in a yeast cell's environmental and developmental states. This data has also, however, provided clues to unraveling the complicated questions surrounding gene regulation: why and how is gene expression controlled?
journal_name
Funct Integr Genomicsjournal_title
Functional & integrative genomicsauthors
Horak CE,Snyder Mdoi
10.1007/s10142-002-0065-3keywords:
subject
Has Abstractpub_date
2002-09-01 00:00:00pages
171-80issue
4-5eissn
1438-793Xissn
1438-7948journal_volume
2pub_type
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journal_title:Functional & integrative genomics
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journal_title:Functional & integrative genomics
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