Comprehensive strategy for the design of precision drugs and identification of genetic signature behind proneness of the disease-a pharmacogenomic approach.

abstract：:Genomic structural variation is an important and abundant source of genetic and phenotypic variation. We previously reported an initial analysis of copy number variations (CNVs) in Angus cattle selected for resistance or susceptibility to gastrointestinal nematodes. In this study, we performed a large-scale analysis o...

journal_title：Functional & integrative genomics

authors： Hou Y,Liu GE,Bickhart DM,Matukumalli LK,Li C,Song J,Gasbarre LC,Van Tassell CP,Sonstegard TS

更新日期：2012-03-01 00:00:00

abstract：:Intronless genes, a characteristic feature of prokaryotes, constitute a significant portion of the eukaryotic genomes. Our analysis revealed the presence of 11,109 (19.9%) and 5,846 (21.7%) intronless genes in rice and Arabidopsis genomes, respectively, belonging to different cellular role and gene ontology categories...

journal_title：Functional & integrative genomics

authors： Jain M,Khurana P,Tyagi AK,Khurana JP

更新日期：2008-02-01 00:00:00

abstract：:Auxin response factors (ARFs) are recently discovered transcription factors that bind with auxin response elements (AuxRE, TGTCTC) to regulate the expression of early auxin-responsive genes. To our knowledge, the ARF gene family has never been characterized in cotton, the most important fiber crop in the world. In thi...

journal_title：Functional & integrative genomics

authors： Sun R,Wang K,Guo T,Jones DC,Cobb J,Zhang B,Wang Q

更新日期：2015-07-01 00:00:00

abstract：:The expression of many genes encoding transcriptional activators in prokaryotes and eukaryotes is upregulated through positive feedback activation. During positive feedback activation, a transcriptional activator binds to its own promoter and thus increases its own expression as well as the expression of its target ge...

journal_title：Functional & integrative genomics

authors： Schwechheimer C,Corke FM,Smith CH,Bevan M

更新日期：2000-05-01 00:00:00

abstract：:The response of a grass halophyte Spartina alterniflora at early stages of salt stress was investigated through generation and systematic analysis of expressed sequence tags (ESTs) from both leaf and root tissues. Random EST sequencing produced 1,227 quality ESTs, which were clustered into 127 contigs, and 368 were si...

journal_title：Functional & integrative genomics

authors： Baisakh N,Subudhi PK,Varadwaj P

更新日期：2008-08-01 00:00:00

abstract：:The root-knot nematode Meloidogyne incognita is among the most damaging plant-parasitic pests of several crops including cotton (Gossypium hirsutum) and tomato (Lycopersicon escultentum). Recently, a genome has become available for M. incognita, which greatly facilitates investigation of the interactions between M. in...

journal_title：Functional & integrative genomics

authors： Zhang Y,Wang Y,Xie F,Li C,Zhang B,Nichols RL,Pan X

更新日期：2016-03-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small RNAs (sRNAs) that regulate gene expression in development and adaptive responses to the environment. The early days in the sRNA field was one of the most exciting and promising moments in modern biology, attracting large investments to the understanding of the underlining mechanisms and th...

journal_title：Functional & integrative genomics

authors： Reis RS

更新日期：2017-05-01 00:00:00

abstract：:Seasonal estrus is a key factor limiting animal fertility, and understanding the molecular mechanisms that regulate animal estrus is important for improving animal fertility. The pituitary gland, which is the most important endocrine gland in mammals, plays an important role in regulating the physiological processes s...

journal_title：Functional & integrative genomics

authors： Li X,Li C,Xu Y,Yao R,Li H,Ni W,Quan R,Zhang M,Liu L,Yu S,Ullah Y,Hu R,Li Y,Guo T,Wang X,Hu S

更新日期：2020-07-01 00:00:00

abstract：:The ubiquitous cell membrane proteins called aquaporins are now firmly established as channel proteins that control the specific transport of water molecules across cell membranes in all living organisms. The aquaporins are thus likely to be of fundamental significance to all facets of plant growth and development aff...

journal_title：Functional & integrative genomics

authors： Forrest KL,Bhave M

更新日期：2007-10-01 00:00:00

abstract：:Comparative genomic analysis is the cornerstone of in silico-based approaches to understanding biological systems and processes across cereal species, such as rice, wheat and barley, in order to identify genes of agronomic interest. The size of the genomic repositories is nearly doubling every year, and this has signi...

journal_title：Functional & integrative genomics

authors： Bellgard M,Ye J,Gojobori T,Appels R

更新日期：2004-03-01 00:00:00

abstract：:The whole genome expression pattern of Arabidopsis in response to the auxinic herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) was evaluated using the Affymetrix ATH1-121501 array. Arabidopsis plants were grown in vitro and were exposed to 1 mM 2,4-D for 1 h, after which time gene transcription levels were measured. I...

journal_title：Functional & integrative genomics

authors： Raghavan C,Ong EK,Dalling MJ,Stevenson TW

更新日期：2005-01-01 00:00:00

abstract：:Although the economic value of wheat flour is determined by the complement of gluten proteins, these proteins have been challenging to study because of the complexity of the major protein groups and the tremendous sequence diversity among wheat cultivars. The completion of a high-quality wheat genome sequence from the...

journal_title：Functional & integrative genomics

authors： Altenbach SB,Chang HC,Simon-Buss A,Mohr T,Huo N,Gu YQ

更新日期：2020-01-01 00:00:00

abstract：:The aim of this study was to examine the effect of abscisic acid (ABA), sucrose, and auxin on grape fruit development and to assess the mechanism of these three factors on the grape fruit ripening process. Different concentrations of ABA, sucrose, and auxin were used to treat the grape fruit, and the ripening-related ...

journal_title：Functional & integrative genomics

authors： Jia H,Xie Z,Wang C,Shangguan L,Qian N,Cui M,Liu Z,Zheng T,Wang M,Fang J

更新日期：2017-07-01 00:00:00

abstract：:Late blight is a serious economic threat to potato crop, sometimes leading to complete crop loss. The resistance in potato to late blight can be qualitative or quantitative in nature. Qualitative resistance is not durable. Though quantitative resistance is durable, the breeding is challenging due to polygenic inherita...

journal_title：Functional & integrative genomics

authors： Yogendra KN,Pushpa D,Mosa KA,Kushalappa AC,Murphy A,Mosquera T

更新日期：2014-06-01 00:00:00

abstract：:Gene order is largely collinear in the small-grained cereals, a feature which has proved helpful in both marker development and positional cloning. The accuracy of a virtual gene order map ("genome zipper") for barley (Hordeum vulgare), developed by combining a genetic map of this species with a large number of gene l...

journal_title：Functional & integrative genomics

authors： Poursarebani N,Ariyadasa R,Zhou R,Schulte D,Steuernagel B,Martis MM,Graner A,Schweizer P,Scholz U,Mayer K,Stein N

更新日期：2013-08-01 00:00:00

abstract：:A cDNA library containing approximately 5,000 clones from germinating barley embryos was constructed and used to examine the variation in gene expression patterns during the first 4 days postimbibition. The expression profiles of embryos (including scutellum) from 4 to 96 h postimbibition were compared to a reference ...

journal_title：Functional & integrative genomics

authors： Watson L,Henry RJ

更新日期：2005-07-01 00:00:00

abstract：:As the amino acid storing organelle, the protein bodies provide nutrients for embryo development, seed germination and early seedling growth through storage proteolysis in cereal plants, such as wheat and rice. In protein bodies, the monomeric and polymeric prolamins, i.e. gliadins and glutenins, form gluten and play ...

journal_title：Functional & integrative genomics

authors： She M,Ye X,Yan Y,Howit C,Belgard M,Ma W

更新日期：2011-03-01 00:00:00

abstract：:The photosynthetic organs of the barley spike (lemma, palea, and awn) are considered resistant to drought. However, there is little information about gene expression in the spike organs under drought conditions. We compared response of the transcriptome of the lemma, palea, awn, and seed to drought stress using the Ba...

journal_title：Functional & integrative genomics

authors： Abebe T,Melmaiee K,Berg V,Wise RP

更新日期：2010-05-01 00:00:00

abstract：:Abiotic stress tolerance is a complex trait regulated by multiple genes and gene networks in plants. A range of abiotic stresses are known to limit rice productivity. Meta-transcriptomics has emerged as a powerful approach to decipher stress-associated molecular network in model crops. However, retaining specificity o...

journal_title：Functional & integrative genomics

authors： Smita S,Katiyar A,Lenka SK,Dalal M,Kumar A,Mahtha SK,Yadav G,Chinnusamy V,Pandey DM,Bansal KC

更新日期：2020-01-01 00:00:00

abstract：:In theory, gene therapy is a simple concept which holds great promise as a cure for disease. In practice, however, considerable obstacles have to be overcome, including problems with safe and efficient gene delivery and stable gene expression. This review gives an overview on the history of gene therapy and analyses s...

journal_title：Functional & integrative genomics

authors： Grosshans H

更新日期：2000-09-01 00:00:00

abstract：:Stem blister canker, caused by Botryosphaeria dothidea, is becoming the most serious disease of poplar in China. The molecular basis of the poplar in response to stem blister canker is not well understood. To reveal the global transcriptional changes of poplar to infection by B. dothidea, Solexa paired-end sequencing ...

journal_title：Functional & integrative genomics

authors： Liao W,Ji L,Wang J,Chen Z,Ye M,Ma H,An X

更新日期：2014-09-01 00:00:00

abstract：:EST-derived microsatellites or simple sequence repeats (eSSR) occur in expressed sequence tags (EST). Here we report characteristics of eSSRs in the wheat genome, construction of consensus chromosome bin maps of SSR-containing ESTs ((SSR)ESTs), and development of eSSR markers for the 21 wheat chromosomes. A Perl scrip...

journal_title：Functional & integrative genomics

authors： Peng JH,Lapitan NL

更新日期：2005-04-01 00:00:00

abstract：:MicroRNAs (miRNAs) play a pivotal role in post-transcriptional regulation of gene expression in plants. In this study, we investigate miRNAs in an agronomically important common tobacco in China, named Honghua Dajinyuan (a drought-tolerant cultivar). Here, we report a comprehensive analysis of miRNA expression profile...

journal_title：Functional & integrative genomics

authors： Yin F,Gao J,Liu M,Qin C,Zhang W,Yang A,Xia M,Zhang Z,Shen Y,Lin H,Luo C,Pan G

更新日期：2014-06-01 00:00:00

abstract：:Microarray experiments are being increasingly used in molecular biology. A common task is to detect genes with differential expression across two experimental conditions, such as two different tissues or the same tissue at two time points of biological development. To take proper account of statistical variability, so...

journal_title：Functional & integrative genomics

authors： Huang X,Pan W

更新日期：2002-08-01 00:00:00

abstract：:The IbeA (ibe10) gene is an invasion determinant contributing to E. coli K1 invasion of the blood-brain barrier. This gene has been cloned and characterized from the chromosome of an invasive cerebrospinal fluid isolate of E. coli K1, strain RS218 (018:K1: H7). In the present study, a genetic island of meningitic E. c...

journal_title：Functional & integrative genomics

authors： Huang SH,Chen YH,Kong G,Chen SH,Besemer J,Borodovsky M,Jong A

更新日期：2001-09-01 00:00:00

abstract：:Carefully analyzed expression profiles can serve as a valuable reference for deciphering gene functions. We exploited the potential of whole genome microarrays to measure the spatial and temporal expression profiles of rice genes in 19 stages of vegetative and reproductive development. We could verify expression of 22...

journal_title：Functional & integrative genomics

authors： Sharma R,Agarwal P,Ray S,Deveshwar P,Sharma P,Sharma N,Nijhawan A,Jain M,Singh AK,Singh VP,Khurana JP,Tyagi AK,Kapoor S

更新日期：2012-06-01 00:00:00

abstract：:Cotton (Gossypium spp.) is an imperative economic crop of the globe due to its natural textile fiber. Molecular mechanisms of fiber development have been greatly revealed in allotetraploid cotton but remained unexplored in Gossypium herbaceum. G. herbaceum can withstand the rigors of nature like drought and pests but ...

journal_title：Functional & integrative genomics

authors： Parekh MJ,Kumar S,Fougat RS,Zala HN,Pandit RJ

更新日期：2018-03-01 00:00:00

abstract：:Winter wheat lines can achieve cold acclimation (development of tolerance to freezing temperatures) and vernalization (delay in transition from vegetative to reproductive phase) in response to low non-freezing temperatures. To describe cold-acclimation-specific processes and pathways, we utilized cold acclimation tran...

journal_title：Functional & integrative genomics

authors： Karki A,Horvath DP,Sutton F

更新日期：2013-03-01 00:00:00

abstract：:Nuclear genomes of human, animals, and plants are organized into subunits called chromosomes. When isolated into aqueous suspension, mitotic chromosomes can be classified using flow cytometry according to light scatter and fluorescence parameters. Chromosomes of interest can be purified by flow sorting if they can be ...

journal_title：Functional & integrative genomics

authors： Doležel J,Vrána J,Safář J,Bartoš J,Kubaláková M,Simková H

更新日期：2012-08-01 00:00:00

abstract：:Jatropha curcas is a new promising bioenergy crop due to the high oil content in its seeds that can be converted into biodiesel. Seed size, a major determinant of Jatropha oil yield, is a target trait for Jatropha breeding. Due to the vital roles of phytohormone auxin in controlling seed and fruit development, we scre...

journal_title：Functional & integrative genomics

authors： Ye J,Liu P,Zhu C,Qu J,Wang X,Sun Y,Sun F,Jiang Y,Yue G,Wang C

更新日期：2014-12-01 00:00:00