Comprehensive strategy for the design of precision drugs and identification of genetic signature behind proneness of the disease-a pharmacogenomic approach.

abstract：:In the past decade, there has been an intense effort to comprehensively catalogue the expressed genes in the yeast Saccharomyces cerevisiae and to determine the absolute and relative abundance of transcript and protein levels under different cellular conditions. Several methods have been developed to monitor gene expr...

journal_title：Functional & integrative genomics

authors： Horak CE,Snyder M

更新日期：2002-09-01 00:00:00

abstract：:The Maize Gene Discovery Project (MGDP) is a 5-year NSF-funded plant genome initiative that began in 1998. The MGDP collaboration involves researchers at six universities from diverse disciplines with the common goal of discovering new maize genes and developing tools for the phenotypic characterization of maize mutan...

journal_title：Functional & integrative genomics

authors： Lunde CF,Morrow DJ,Roy LM,Walbot V

更新日期：2003-03-01 00:00:00

abstract：:Seasonal estrus is a key factor limiting animal fertility, and understanding the molecular mechanisms that regulate animal estrus is important for improving animal fertility. The pituitary gland, which is the most important endocrine gland in mammals, plays an important role in regulating the physiological processes s...

journal_title：Functional & integrative genomics

authors： Li X,Li C,Xu Y,Yao R,Li H,Ni W,Quan R,Zhang M,Liu L,Yu S,Ullah Y,Hu R,Li Y,Guo T,Wang X,Hu S

更新日期：2020-07-01 00:00:00

abstract：:Late blight is a serious economic threat to potato crop, sometimes leading to complete crop loss. The resistance in potato to late blight can be qualitative or quantitative in nature. Qualitative resistance is not durable. Though quantitative resistance is durable, the breeding is challenging due to polygenic inherita...

journal_title：Functional & integrative genomics

authors： Yogendra KN,Pushpa D,Mosa KA,Kushalappa AC,Murphy A,Mosquera T

更新日期：2014-06-01 00:00:00

abstract：:Genomic structural variation is an important and abundant source of genetic and phenotypic variation. We previously reported an initial analysis of copy number variations (CNVs) in Angus cattle selected for resistance or susceptibility to gastrointestinal nematodes. In this study, we performed a large-scale analysis o...

journal_title：Functional & integrative genomics

authors： Hou Y,Liu GE,Bickhart DM,Matukumalli LK,Li C,Song J,Gasbarre LC,Van Tassell CP,Sonstegard TS

更新日期：2012-03-01 00:00:00

abstract：:MicroRNAs, small regulatory molecules with significant impacts on the transcriptional network of all living organisms, have been the focus of several studies conducted mostly on modern wheat cultivars. In this study, we investigated miRNA repertoires of modern durum wheat and its wild relatives, with differing degrees...

journal_title：Functional & integrative genomics

authors： Akpinar BA,Kantar M,Budak H

更新日期：2015-09-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small RNAs (sRNAs) that regulate gene expression in development and adaptive responses to the environment. The early days in the sRNA field was one of the most exciting and promising moments in modern biology, attracting large investments to the understanding of the underlining mechanisms and th...

journal_title：Functional & integrative genomics

authors： Reis RS

更新日期：2017-05-01 00:00:00

abstract：:In theory, gene therapy is a simple concept which holds great promise as a cure for disease. In practice, however, considerable obstacles have to be overcome, including problems with safe and efficient gene delivery and stable gene expression. This review gives an overview on the history of gene therapy and analyses s...

journal_title：Functional & integrative genomics

authors： Grosshans H

更新日期：2000-09-01 00:00:00

abstract：:Microarray experiments are being increasingly used in molecular biology. A common task is to detect genes with differential expression across two experimental conditions, such as two different tissues or the same tissue at two time points of biological development. To take proper account of statistical variability, so...

journal_title：Functional & integrative genomics

authors： Huang X,Pan W

更新日期：2002-08-01 00:00:00

abstract：:Campylobacter jejuni remains a major cause of human gastroenteritis with estimated annual incidence rate of 450 million infections worldwide. C. jejuni is a major burden to public health in both socioeconomically developing and industrialized nations. Virulence determinants involved in C. jejuni pathogenesis are multi...

journal_title：Functional & integrative genomics

authors： Mehla K,Ramana J

更新日期：2017-01-01 00:00:00

abstract：:Cotton (Gossypium spp.) is an imperative economic crop of the globe due to its natural textile fiber. Molecular mechanisms of fiber development have been greatly revealed in allotetraploid cotton but remained unexplored in Gossypium herbaceum. G. herbaceum can withstand the rigors of nature like drought and pests but ...

journal_title：Functional & integrative genomics

authors： Parekh MJ,Kumar S,Fougat RS,Zala HN,Pandit RJ

更新日期：2018-03-01 00:00:00

abstract：:We have previously reported that the deletion of BMAL1 gene has opposite effects in respect to its contribution to the pathways that are effective in the multistage carcinogenesis process. BMAL1 deletion sensitized nearly normal breast epithelial (MCF10A) and invasive breast cancer cells (MDA-MB-231) to cisplatin- and...

journal_title：Functional & integrative genomics

authors： Emisoglu-Kulahli H,Gul S,Morgil H,Ozcan O,Aygenli F,Selvi S,Kavakli IH,Ozturk N

更新日期：2021-01-01 00:00:00

abstract：:The ever-rising population of the twenty-first century together with the prevailing challenges, such as deteriorating quality of arable land and water, has placed a big challenge for plant breeders to satisfy human needs for food under erratic weather patterns. Rice, wheat, and maize are the major staple crops consume...

journal_title：Functional & integrative genomics

authors： Choudhary M,Wani SH,Kumar P,Bagaria PK,Rakshit S,Roorkiwal M,Varshney RK

更新日期：2019-09-01 00:00:00

abstract：:The root-knot nematode Meloidogyne incognita is among the most damaging plant-parasitic pests of several crops including cotton (Gossypium hirsutum) and tomato (Lycopersicon escultentum). Recently, a genome has become available for M. incognita, which greatly facilitates investigation of the interactions between M. in...

journal_title：Functional & integrative genomics

authors： Zhang Y,Wang Y,Xie F,Li C,Zhang B,Nichols RL,Pan X

更新日期：2016-03-01 00:00:00

abstract：:The ATP-binding cassette (ABC) transporters are a large family of proteins responsible for the translocation of a variety of compounds across the membranes of both prokaryotes and eukaryotes. The inter-protein and intra-protein interactions in these traffic ATPases are still only poorly understood. In the present stud...

journal_title：Functional & integrative genomics

authors： Subba Rao G,Bachhawat AK,Gupta CM

更新日期：2002-04-01 00:00:00

abstract：:The oomycete pathogen Plasmopara viticola (Berk. et Curt.) Berl. et de Toni is the causing agent of the destructive downy mildew disease in grapevine. Despite the advances towards elucidation of grapevine resistance mechanisms to downy mildew, increased knowledge of the biological and genetic components of the pathosy...

journal_title：Functional & integrative genomics

authors： Figueiredo A,Monteiro F,Fortes AM,Bonow-Rex M,Zyprian E,Sousa L,Pais MS

更新日期：2012-06-01 00:00:00

abstract：:As the amino acid storing organelle, the protein bodies provide nutrients for embryo development, seed germination and early seedling growth through storage proteolysis in cereal plants, such as wheat and rice. In protein bodies, the monomeric and polymeric prolamins, i.e. gliadins and glutenins, form gluten and play ...

journal_title：Functional & integrative genomics

authors： She M,Ye X,Yan Y,Howit C,Belgard M,Ma W

更新日期：2011-03-01 00:00:00

abstract：:Comparative genomic analysis is the cornerstone of in silico-based approaches to understanding biological systems and processes across cereal species, such as rice, wheat and barley, in order to identify genes of agronomic interest. The size of the genomic repositories is nearly doubling every year, and this has signi...

journal_title：Functional & integrative genomics

authors： Bellgard M,Ye J,Gojobori T,Appels R

更新日期：2004-03-01 00:00:00

abstract：:Bread wheat (Triticum aestivum L.) is one of the most important crops globally and a high priority for genetic improvement, but its large and complex genome has been seen as intractable to whole genome sequencing. Isolation of individual wheat chromosome arms has facilitated large-scale sequence analyses. However, so ...

journal_title：Functional & integrative genomics

authors： Lucas SJ,Šimková H,Šafář J,Jurman I,Cattonaro F,Vautrin S,Bellec A,Berges H,Doležel J,Budak H

更新日期：2012-03-01 00:00:00

abstract：:Recent updates in comparative genomics among cereals have provided the opportunity to identify conserved orthologous set (COS) DNA sequences for cross-genome map-based cloning of candidate genes underpinning quantitative traits. New tools are described that are applicable to any cereal genome of interest, namely, alig...

journal_title：Functional & integrative genomics

authors： Quraishi UM,Abrouk M,Bolot S,Pont C,Throude M,Guilhot N,Confolent C,Bortolini F,Praud S,Murigneux A,Charmet G,Salse J

更新日期：2009-11-01 00:00:00

abstract：:GDSL-type esterase/lipase (GELP) is mainly characterized by a conserved GDSL domain at N terminus, and is widely found in all living species, both prokaryotes and eukaryotes. GELP gene family consists of a wide range of members playing important roles in plant physiological processes, such as development, stress respo...

journal_title：Functional & integrative genomics

authors： Cao Y,Han Y,Meng D,Abdullah M,Yu J,Li D,Jin Q,Lin Y,Cai Y

更新日期：2018-11-01 00:00:00

abstract：:Jatropha curcas is a new promising bioenergy crop due to the high oil content in its seeds that can be converted into biodiesel. Seed size, a major determinant of Jatropha oil yield, is a target trait for Jatropha breeding. Due to the vital roles of phytohormone auxin in controlling seed and fruit development, we scre...

journal_title：Functional & integrative genomics

authors： Ye J,Liu P,Zhu C,Qu J,Wang X,Sun Y,Sun F,Jiang Y,Yue G,Wang C

更新日期：2014-12-01 00:00:00

abstract：:Stem blister canker, caused by Botryosphaeria dothidea, is becoming the most serious disease of poplar in China. The molecular basis of the poplar in response to stem blister canker is not well understood. To reveal the global transcriptional changes of poplar to infection by B. dothidea, Solexa paired-end sequencing ...

journal_title：Functional & integrative genomics

authors： Liao W,Ji L,Wang J,Chen Z,Ye M,Ma H,An X

更新日期：2014-09-01 00:00:00

abstract：:The response of a grass halophyte Spartina alterniflora at early stages of salt stress was investigated through generation and systematic analysis of expressed sequence tags (ESTs) from both leaf and root tissues. Random EST sequencing produced 1,227 quality ESTs, which were clustered into 127 contigs, and 368 were si...

journal_title：Functional & integrative genomics

authors： Baisakh N,Subudhi PK,Varadwaj P

更新日期：2008-08-01 00:00:00

abstract：:Water temperature affects the survival, growth, immunity, reproduction, and productivity of farmed fish. The temperature beyond suitable range will disrupt the normal physiological activity. Common carp (Cyprinus carpio L.) is a representative eurythermic fish; they are able to sense and respond to changes in water te...

journal_title：Functional & integrative genomics

authors： Sun J,Zhao L,Wu H,Lian W,Cui C,Du Z,Luo W,Li M,Yang S

更新日期：2019-03-01 00:00:00

abstract：:Natural selection drives species adaptations to biotic and abiotic stresses. Species distributed along a moisture gradient, such as Stipa purpurea, a dominant grass in alpine arid and semi-arid meadows on the Tibetan Plateau, provide an opportunity to evaluate the effects of long-term adaptation to differing degrees o...

journal_title：Functional & integrative genomics

authors： Yang Y,Li X,Kong X,Ma L,Hu X,Yang Y

更新日期：2015-05-01 00:00:00

abstract：:GRAS domain genes are a group of important plant-specific transcription factors that have been reported to be involved in plant development. In order to know the roles of GRAS genes in grapevine, a widely cultivated fruit crop, the study on grapevine GRAS (VvGRAS) was carried out, and from which, 43 were identified fr...

journal_title：Functional & integrative genomics

authors： Sun X,Xie Z,Zhang C,Mu Q,Wu W,Wang B,Fang J

更新日期：2016-07-01 00:00:00

abstract：:EST-derived microsatellites or simple sequence repeats (eSSR) occur in expressed sequence tags (EST). Here we report characteristics of eSSRs in the wheat genome, construction of consensus chromosome bin maps of SSR-containing ESTs ((SSR)ESTs), and development of eSSR markers for the 21 wheat chromosomes. A Perl scrip...

journal_title：Functional & integrative genomics

authors： Peng JH,Lapitan NL

更新日期：2005-04-01 00:00:00

abstract：:Although the economic value of wheat flour is determined by the complement of gluten proteins, these proteins have been challenging to study because of the complexity of the major protein groups and the tremendous sequence diversity among wheat cultivars. The completion of a high-quality wheat genome sequence from the...

journal_title：Functional & integrative genomics

authors： Altenbach SB,Chang HC,Simon-Buss A,Mohr T,Huo N,Gu YQ

更新日期：2020-01-01 00:00:00

abstract：:The whole genome expression pattern of Arabidopsis in response to the auxinic herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) was evaluated using the Affymetrix ATH1-121501 array. Arabidopsis plants were grown in vitro and were exposed to 1 mM 2,4-D for 1 h, after which time gene transcription levels were measured. I...

journal_title：Functional & integrative genomics

authors： Raghavan C,Ong EK,Dalling MJ,Stevenson TW

更新日期：2005-01-01 00:00:00