Comprehensive strategy for the design of precision drugs and identification of genetic signature behind proneness of the disease-a pharmacogenomic approach.


:The proneness of diseases and susceptibility towards drugs vary from person to person. At present, there is a strong demand for the personalization of drugs. The genetic signature behind proneness of the disease has been studied through a comprehensive 'octopodial approach'. All the genetic variants included in the approach have been introduced. The breast cancer associated with BRCA1 mutation has been taken as the illustrative example to introduce all these factors. The genetic variants associated with the drug action of tamoxifen have been fully illustrated in the manuscript. The design of a new personalized anti-breast cancer drug has been explained in the third phase. For the design of new personalized drugs, a metabolite of anti-cancer drug chlorambucil has been taken as the template. The design of drug has been made with respect to the protein 1T15 of BRCA1 gene corresponding to the genetic signature of rs28897696.


Funct Integr Genomics


Iyer PM,Karthikeyan S,Sanjay Kumar P,Krishnan Namboori PK




Has Abstract


2017-07-01 00:00:00














  • Genomic regions showing copy number variations associate with resistance or susceptibility to gastrointestinal nematodes in Angus cattle.

    abstract::Genomic structural variation is an important and abundant source of genetic and phenotypic variation. We previously reported an initial analysis of copy number variations (CNVs) in Angus cattle selected for resistance or susceptibility to gastrointestinal nematodes. In this study, we performed a large-scale analysis o...

    journal_title:Functional & integrative genomics

    pub_type: 杂志文章


    authors: Hou Y,Liu GE,Bickhart DM,Matukumalli LK,Li C,Song J,Gasbarre LC,Van Tassell CP,Sonstegard TS

    更新日期:2012-03-01 00:00:00

  • Genome-wide analysis of intronless genes in rice and Arabidopsis.

    abstract::Intronless genes, a characteristic feature of prokaryotes, constitute a significant portion of the eukaryotic genomes. Our analysis revealed the presence of 11,109 (19.9%) and 5,846 (21.7%) intronless genes in rice and Arabidopsis genomes, respectively, belonging to different cellular role and gene ontology categories...

    journal_title:Functional & integrative genomics

    pub_type: 杂志文章


    authors: Jain M,Khurana P,Tyagi AK,Khurana JP

    更新日期:2008-02-01 00:00:00

  • Genome-wide identification of auxin response factor (ARF) genes and its tissue-specific prominent expression in Gossypium raimondii.

    abstract::Auxin response factors (ARFs) are recently discovered transcription factors that bind with auxin response elements (AuxRE, TGTCTC) to regulate the expression of early auxin-responsive genes. To our knowledge, the ARF gene family has never been characterized in cotton, the most important fiber crop in the world. In thi...

    journal_title:Functional & integrative genomics

    pub_type: 杂志文章


    authors: Sun R,Wang K,Guo T,Jones DC,Cobb J,Zhang B,Wang Q

    更新日期:2015-07-01 00:00:00

  • Transactivation of a target gene through feedforward loop activation in plants.

    abstract::The expression of many genes encoding transcriptional activators in prokaryotes and eukaryotes is upregulated through positive feedback activation. During positive feedback activation, a transcriptional activator binds to its own promoter and thus increases its own expression as well as the expression of its target ge...

    journal_title:Functional & integrative genomics

    pub_type: 杂志文章


    authors: Schwechheimer C,Corke FM,Smith CH,Bevan M

    更新日期:2000-05-01 00:00:00

  • Primary responses to salt stress in a halophyte, smooth cordgrass (Spartina alterniflora Loisel.).

    abstract::The response of a grass halophyte Spartina alterniflora at early stages of salt stress was investigated through generation and systematic analysis of expressed sequence tags (ESTs) from both leaf and root tissues. Random EST sequencing produced 1,227 quality ESTs, which were clustered into 127 contigs, and 368 were si...

    journal_title:Functional & integrative genomics

    pub_type: 杂志文章


    authors: Baisakh N,Subudhi PK,Varadwaj P

    更新日期:2008-08-01 00:00:00

  • Identification and characterization of microRNAs in the plant parasitic root-knot nematode Meloidogyne incognita using deep sequencing.

    abstract::The root-knot nematode Meloidogyne incognita is among the most damaging plant-parasitic pests of several crops including cotton (Gossypium hirsutum) and tomato (Lycopersicon escultentum). Recently, a genome has become available for M. incognita, which greatly facilitates investigation of the interactions between M. in...

    journal_title:Functional & integrative genomics

    pub_type: 杂志文章


    authors: Zhang Y,Wang Y,Xie F,Li C,Zhang B,Nichols RL,Pan X

    更新日期:2016-03-01 00:00:00

  • The entangled history of animal and plant microRNAs.

    abstract::MicroRNAs (miRNAs) are small RNAs (sRNAs) that regulate gene expression in development and adaptive responses to the environment. The early days in the sRNA field was one of the most exciting and promising moments in modern biology, attracting large investments to the understanding of the underlining mechanisms and th...

    journal_title:Functional & integrative genomics

    pub_type: 杂志文章,评审


    authors: Reis RS

    更新日期:2017-05-01 00:00:00

  • Analysis of pituitary transcriptomics indicates that lncRNAs are involved in the regulation of sheep estrus.

    abstract::Seasonal estrus is a key factor limiting animal fertility, and understanding the molecular mechanisms that regulate animal estrus is important for improving animal fertility. The pituitary gland, which is the most important endocrine gland in mammals, plays an important role in regulating the physiological processes s...

    journal_title:Functional & integrative genomics

    pub_type: 杂志文章


    authors: Li X,Li C,Xu Y,Yao R,Li H,Ni W,Quan R,Zhang M,Liu L,Yu S,Ullah Y,Hu R,Li Y,Guo T,Wang X,Hu S

    更新日期:2020-07-01 00:00:00

  • Major intrinsic proteins (MIPs) in plants: a complex gene family with major impacts on plant phenotype.

    abstract::The ubiquitous cell membrane proteins called aquaporins are now firmly established as channel proteins that control the specific transport of water molecules across cell membranes in all living organisms. The aquaporins are thus likely to be of fundamental significance to all facets of plant growth and development aff...

    journal_title:Functional & integrative genomics

    pub_type: 杂志文章,评审


    authors: Forrest KL,Bhave M

    更新日期:2007-10-01 00:00:00

  • The bioinformatics challenges in comparative analysis of cereal genomes-an overview.

    abstract::Comparative genomic analysis is the cornerstone of in silico-based approaches to understanding biological systems and processes across cereal species, such as rice, wheat and barley, in order to identify genes of agronomic interest. The size of the genomic repositories is nearly doubling every year, and this has signi...

    journal_title:Functional & integrative genomics

    pub_type: 杂志文章,评审


    authors: Bellgard M,Ye J,Gojobori T,Appels R

    更新日期:2004-03-01 00:00:00

  • Effect of herbicidal application of 2,4-dichlorophenoxyacetic acid in Arabidopsis.

    abstract::The whole genome expression pattern of Arabidopsis in response to the auxinic herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) was evaluated using the Affymetrix ATH1-121501 array. Arabidopsis plants were grown in vitro and were exposed to 1 mM 2,4-D for 1 h, after which time gene transcription levels were measured. I...

    journal_title:Functional & integrative genomics

    pub_type: 杂志文章


    authors: Raghavan C,Ong EK,Dalling MJ,Stevenson TW

    更新日期:2005-01-01 00:00:00

  • Exploiting the reference genome sequence of hexaploid wheat: a proteomic study of flour proteins from the cultivar Chinese Spring.

    abstract::Although the economic value of wheat flour is determined by the complement of gluten proteins, these proteins have been challenging to study because of the complexity of the major protein groups and the tremendous sequence diversity among wheat cultivars. The completion of a high-quality wheat genome sequence from the...

    journal_title:Functional & integrative genomics

    pub_type: 杂志文章


    authors: Altenbach SB,Chang HC,Simon-Buss A,Mohr T,Huo N,Gu YQ

    更新日期:2020-01-01 00:00:00

  • Abscisic acid, sucrose, and auxin coordinately regulate berry ripening process of the Fujiminori grape.

    abstract::The aim of this study was to examine the effect of abscisic acid (ABA), sucrose, and auxin on grape fruit development and to assess the mechanism of these three factors on the grape fruit ripening process. Different concentrations of ABA, sucrose, and auxin were used to treat the grape fruit, and the ripening-related ...

    journal_title:Functional & integrative genomics

    pub_type: 杂志文章


    authors: Jia H,Xie Z,Wang C,Shangguan L,Qian N,Cui M,Liu Z,Zheng T,Wang M,Fang J

    更新日期:2017-07-01 00:00:00

  • Quantitative resistance in potato leaves to late blight associated with induced hydroxycinnamic acid amides.

    abstract::Late blight is a serious economic threat to potato crop, sometimes leading to complete crop loss. The resistance in potato to late blight can be qualitative or quantitative in nature. Qualitative resistance is not durable. Though quantitative resistance is durable, the breeding is challenging due to polygenic inherita...

    journal_title:Functional & integrative genomics

    pub_type: 杂志文章


    authors: Yogendra KN,Pushpa D,Mosa KA,Kushalappa AC,Murphy A,Mosquera T

    更新日期:2014-06-01 00:00:00

  • Conserved synteny-based anchoring of the barley genome physical map.

    abstract::Gene order is largely collinear in the small-grained cereals, a feature which has proved helpful in both marker development and positional cloning. The accuracy of a virtual gene order map ("genome zipper") for barley (Hordeum vulgare), developed by combining a genetic map of this species with a large number of gene l...

    journal_title:Functional & integrative genomics

    pub_type: 杂志文章


    authors: Poursarebani N,Ariyadasa R,Zhou R,Schulte D,Steuernagel B,Martis MM,Graner A,Schweizer P,Scholz U,Mayer K,Stein N

    更新日期:2013-08-01 00:00:00

  • Microarray analysis of gene expression in germinating barley embryos (Hordeum vulgare L.).

    abstract::A cDNA library containing approximately 5,000 clones from germinating barley embryos was constructed and used to examine the variation in gene expression patterns during the first 4 days postimbibition. The expression profiles of embryos (including scutellum) from 4 to 96 h postimbibition were compared to a reference ...

    journal_title:Functional & integrative genomics

    pub_type: 杂志文章


    authors: Watson L,Henry RJ

    更新日期:2005-07-01 00:00:00

  • Gene networks in the synthesis and deposition of protein polymers during grain development of wheat.

    abstract::As the amino acid storing organelle, the protein bodies provide nutrients for embryo development, seed germination and early seedling growth through storage proteolysis in cereal plants, such as wheat and rice. In protein bodies, the monomeric and polymeric prolamins, i.e. gliadins and glutenins, form gluten and play ...

    journal_title:Functional & integrative genomics

    pub_type: 杂志文章,评审


    authors: She M,Ye X,Yan Y,Howit C,Belgard M,Ma W

    更新日期:2011-03-01 00:00:00

  • Drought response in the spikes of barley: gene expression in the lemma, palea, awn, and seed.

    abstract::The photosynthetic organs of the barley spike (lemma, palea, and awn) are considered resistant to drought. However, there is little information about gene expression in the spike organs under drought conditions. We compared response of the transcriptome of the lemma, palea, awn, and seed to drought stress using the Ba...

    journal_title:Functional & integrative genomics

    pub_type: 杂志文章


    authors: Abebe T,Melmaiee K,Berg V,Wise RP

    更新日期:2010-05-01 00:00:00

  • Gene network modules associated with abiotic stress response in tolerant rice genotypes identified by transcriptome meta-analysis.

    abstract::Abiotic stress tolerance is a complex trait regulated by multiple genes and gene networks in plants. A range of abiotic stresses are known to limit rice productivity. Meta-transcriptomics has emerged as a powerful approach to decipher stress-associated molecular network in model crops. However, retaining specificity o...

    journal_title:Functional & integrative genomics

    pub_type: 杂志文章,meta分析


    authors: Smita S,Katiyar A,Lenka SK,Dalal M,Kumar A,Mahtha SK,Yadav G,Chinnusamy V,Pandey DM,Bansal KC

    更新日期:2020-01-01 00:00:00

  • Gene therapy--when a simple concept meets a complex reality. Review on gene therapy.

    abstract::In theory, gene therapy is a simple concept which holds great promise as a cure for disease. In practice, however, considerable obstacles have to be overcome, including problems with safe and efficient gene delivery and stable gene expression. This review gives an overview on the history of gene therapy and analyses s...

    journal_title:Functional & integrative genomics

    pub_type: 杂志文章,评审


    authors: Grosshans H

    更新日期:2000-09-01 00:00:00

  • Identification of glutathione S-transferase genes responding to pathogen infestation in Populus tomentosa.

    abstract::Stem blister canker, caused by Botryosphaeria dothidea, is becoming the most serious disease of poplar in China. The molecular basis of the poplar in response to stem blister canker is not well understood. To reveal the global transcriptional changes of poplar to infection by B. dothidea, Solexa paired-end sequencing ...

    journal_title:Functional & integrative genomics

    pub_type: 杂志文章


    authors: Liao W,Ji L,Wang J,Chen Z,Ye M,Ma H,An X

    更新日期:2014-09-01 00:00:00

  • Characterization of EST-derived microsatellites in the wheat genome and development of eSSR markers.

    abstract::EST-derived microsatellites or simple sequence repeats (eSSR) occur in expressed sequence tags (EST). Here we report characteristics of eSSRs in the wheat genome, construction of consensus chromosome bin maps of SSR-containing ESTs ((SSR)ESTs), and development of eSSR markers for the 21 wheat chromosomes. A Perl scrip...

    journal_title:Functional & integrative genomics

    pub_type: 杂志文章


    authors: Peng JH,Lapitan NL

    更新日期:2005-04-01 00:00:00

  • Genome-wide analysis of water-stress-responsive microRNA expression profile in tobacco roots.

    abstract::MicroRNAs (miRNAs) play a pivotal role in post-transcriptional regulation of gene expression in plants. In this study, we investigate miRNAs in an agronomically important common tobacco in China, named Honghua Dajinyuan (a drought-tolerant cultivar). Here, we report a comprehensive analysis of miRNA expression profile...

    journal_title:Functional & integrative genomics

    pub_type: 杂志文章


    authors: Yin F,Gao J,Liu M,Qin C,Zhang W,Yang A,Xia M,Zhang Z,Shen Y,Lin H,Luo C,Pan G

    更新日期:2014-06-01 00:00:00

  • Comparing three methods for variance estimation with duplicated high density oligonucleotide arrays.

    abstract::Microarray experiments are being increasingly used in molecular biology. A common task is to detect genes with differential expression across two experimental conditions, such as two different tissues or the same tissue at two time points of biological development. To take proper account of statistical variability, so...

    journal_title:Functional & integrative genomics

    pub_type: 杂志文章


    authors: Huang X,Pan W

    更新日期:2002-08-01 00:00:00

  • A novel genetic island of meningitic Escherichia coli K1 containing the ibeA invasion gene (GimA): functional annotation and carbon-source-regulated invasion of human brain microvascular endothelial cells.

    abstract::The IbeA (ibe10) gene is an invasion determinant contributing to E. coli K1 invasion of the blood-brain barrier. This gene has been cloned and characterized from the chromosome of an invasive cerebrospinal fluid isolate of E. coli K1, strain RS218 (018:K1: H7). In the present study, a genetic island of meningitic E. c...

    journal_title:Functional & integrative genomics

    pub_type: 杂志文章


    authors: Huang SH,Chen YH,Kong G,Chen SH,Besemer J,Borodovsky M,Jong A

    更新日期:2001-09-01 00:00:00

  • Expression dynamics of metabolic and regulatory components across stages of panicle and seed development in indica rice.

    abstract::Carefully analyzed expression profiles can serve as a valuable reference for deciphering gene functions. We exploited the potential of whole genome microarrays to measure the spatial and temporal expression profiles of rice genes in 19 stages of vegetative and reproductive development. We could verify expression of 22...

    journal_title:Functional & integrative genomics

    pub_type: 杂志文章


    authors: Sharma R,Agarwal P,Ray S,Deveshwar P,Sharma P,Sharma N,Nijhawan A,Jain M,Singh AK,Singh VP,Khurana JP,Tyagi AK,Kapoor S

    更新日期:2012-06-01 00:00:00

  • Transcriptomic profiling of developing fiber in levant cotton (Gossypium herbaceum L.).

    abstract::Cotton (Gossypium spp.) is an imperative economic crop of the globe due to its natural textile fiber. Molecular mechanisms of fiber development have been greatly revealed in allotetraploid cotton but remained unexplored in Gossypium herbaceum. G. herbaceum can withstand the rigors of nature like drought and pests but ...

    journal_title:Functional & integrative genomics

    pub_type: 杂志文章


    authors: Parekh MJ,Kumar S,Fougat RS,Zala HN,Pandit RJ

    更新日期:2018-03-01 00:00:00

  • Induction of DREB2A pathway with repression of E2F, jasmonic acid biosynthetic and photosynthesis pathways in cold acclimation-specific freeze-resistant wheat crown.

    abstract::Winter wheat lines can achieve cold acclimation (development of tolerance to freezing temperatures) and vernalization (delay in transition from vegetative to reproductive phase) in response to low non-freezing temperatures. To describe cold-acclimation-specific processes and pathways, we utilized cold acclimation tran...

    journal_title:Functional & integrative genomics

    pub_type: 杂志文章


    authors: Karki A,Horvath DP,Sutton F

    更新日期:2013-03-01 00:00:00

  • Chromosomes in the flow to simplify genome analysis.

    abstract::Nuclear genomes of human, animals, and plants are organized into subunits called chromosomes. When isolated into aqueous suspension, mitotic chromosomes can be classified using flow cytometry according to light scatter and fluorescence parameters. Chromosomes of interest can be purified by flow sorting if they can be ...

    journal_title:Functional & integrative genomics

    pub_type: 杂志文章,评审


    authors: Doležel J,Vrána J,Safář J,Bartoš J,Kubaláková M,Simková H

    更新日期:2012-08-01 00:00:00

  • Identification of candidate genes JcARF19 and JcIAA9 associated with seed size traits in Jatropha.

    abstract::Jatropha curcas is a new promising bioenergy crop due to the high oil content in its seeds that can be converted into biodiesel. Seed size, a major determinant of Jatropha oil yield, is a target trait for Jatropha breeding. Due to the vital roles of phytohormone auxin in controlling seed and fruit development, we scre...

    journal_title:Functional & integrative genomics

    pub_type: 杂志文章


    authors: Ye J,Liu P,Zhu C,Qu J,Wang X,Sun Y,Sun F,Jiang Y,Yue G,Wang C

    更新日期:2014-12-01 00:00:00