Abstract:
:Seasonal estrus is a key factor limiting animal fertility, and understanding the molecular mechanisms that regulate animal estrus is important for improving animal fertility. The pituitary gland, which is the most important endocrine gland in mammals, plays an important role in regulating the physiological processes such as growth, development, and reproduction of animals. Here, we used RNA-seq technology to study the expression profile of lncRNAs in the anterior pituitary of sheep during estrus and anestrus. In this study, we identified a total of 995 lncRNAs, of which 335 lncRNAs were differentially expressed in two states (including 38 up-regulated and 297 down-regulated lncRNAs). RT-qPCR verified the expression levels of several lncRNAs. Target predictive analysis revealed that these lncRNAs can act in cis or trans and regulate the expression of genes involved in the regulation of sheep estrus. Target gene enrichment analysis of differentially expressed lncRNAs indicates that these lncRNAs can regulate sheep estrus by regulating hormone metabolism and energy metabolism. Through our research, we provide the expression profile of lncRNAs in the pituitary of sheep, which provides a valuable resource for further understanding of the genetic regulation of seasonal estrus in sheep from the perspective of lncRNAs.
journal_name
Funct Integr Genomicsjournal_title
Functional & integrative genomicsauthors
Li X,Li C,Xu Y,Yao R,Li H,Ni W,Quan R,Zhang M,Liu L,Yu S,Ullah Y,Hu R,Li Y,Guo T,Wang X,Hu Sdoi
10.1007/s10142-020-00735-ysubject
Has Abstractpub_date
2020-07-01 00:00:00pages
563-573issue
4eissn
1438-793Xissn
1438-7948pii
10.1007/s10142-020-00735-yjournal_volume
20pub_type
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journal_title:Functional & integrative genomics
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journal_title:Functional & integrative genomics
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journal_title:Functional & integrative genomics
pub_type: 杂志文章,评审
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journal_title:Functional & integrative genomics
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doi:10.1007/s10142-015-0472-x
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journal_title:Functional & integrative genomics
pub_type: 杂志文章
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journal_title:Functional & integrative genomics
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journal_title:Functional & integrative genomics
pub_type: 杂志文章
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journal_title:Functional & integrative genomics
pub_type: 杂志文章
doi:10.1007/s10142-004-0128-8
更新日期:2005-04-01 00:00:00
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journal_title:Functional & integrative genomics
pub_type: 杂志文章
doi:10.1007/s10142-014-0405-0
更新日期:2014-12-01 00:00:00
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journal_title:Functional & integrative genomics
pub_type: 杂志文章
doi:10.1007/s10142-001-0040-4
更新日期:2002-04-01 00:00:00
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journal_title:Functional & integrative genomics
pub_type: 杂志文章
doi:10.1007/s10142-017-0546-z
更新日期:2017-07-01 00:00:00
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journal_title:Functional & integrative genomics
pub_type: 杂志文章
doi:10.1007/s10142-014-0407-y
更新日期:2015-01-01 00:00:00
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journal_title:Functional & integrative genomics
pub_type: 杂志文章
doi:10.1007/s10142-014-0400-5
更新日期:2014-12-01 00:00:00
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journal_title:Functional & integrative genomics
pub_type: 杂志文章,评审
doi:10.1007/s10142-002-0078-y
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journal_title:Functional & integrative genomics
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doi:10.1007/s10142-017-0575-7
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journal_title:Functional & integrative genomics
pub_type: 杂志文章,评审
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journal_title:Functional & integrative genomics
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journal_title:Functional & integrative genomics
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journal_title:Functional & integrative genomics
pub_type: 杂志文章
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journal_title:Functional & integrative genomics
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journal_title:Functional & integrative genomics
pub_type: 杂志文章,评审
doi:10.1007/s10142-019-00684-1
更新日期:2019-09-01 00:00:00
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journal_title:Functional & integrative genomics
pub_type: 杂志文章,评审
doi:10.1007/s10142-004-0102-5
更新日期:2004-03-01 00:00:00
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journal_title:Functional & integrative genomics
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journal_title:Functional & integrative genomics
pub_type: 杂志文章
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journal_title:Functional & integrative genomics
pub_type: 杂志文章
doi:10.1007/s10142-002-0055-5
更新日期:2002-05-01 00:00:00
abstract::Microarray experiments are being increasingly used in molecular biology. A common task is to detect genes with differential expression across two experimental conditions, such as two different tissues or the same tissue at two time points of biological development. To take proper account of statistical variability, so...
journal_title:Functional & integrative genomics
pub_type: 杂志文章
doi:10.1007/s10142-002-0066-2
更新日期:2002-08-01 00:00:00
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journal_title:Functional & integrative genomics
pub_type: 杂志文章
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