Abstract：
:The symbiotic N(2)-fixing alpha-proteobacterium Sinorhizobium meliloti has three replicons: a circular chromosome (3.7 Mb) and two smaller replicons, pSymA (1.4 Mb) and pSymB (1.7 Mb). Sequence analysis has revealed that an essential gene is carried on pSymB, which brings into question whether pSymB should be considered a chromosome or a plasmid. Based on the criterion that essential genes define a chromosome, several species have been shown to have multiple chromosomes. Many of these species are part of the alpha subdivision of the Proteobacteria family. Here, additional justification is presented for designating the pSymB replicon as a chromosome. It is shown that chromosomes within a species share a more similar dinucleotide composition, or genome signature, than plasmids do with the host chromosome(s). Dinucleotide signatures were determined for each of the S. meliloti replicons, and, consistent with the suggestion that pSymB is a chromosome, it is shown that the pSymB signature more closely resembles that of the S. meliloti chromosome, while the pSymA signature is typical of other alpha-proteobacterial plasmids.
journal_name
Funct Integr Genomicsjournal_title
Functional & integrative genomicsauthors
Wong K,Finan TM,Golding GBdoi
10.1007/s10142-002-0068-0keywords:
subject
Has Abstractpub_date
2002-11-01 00:00:00pages
274-81issue
6eissn
1438-793Xissn
1438-7948journal_volume
2pub_type
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