Abstract:
:Wounds on fetal skin can be repaired without leaving scars until the second trimester, but after this period, skin wounds leave scars as in adults. It's known that certain growth factors such as TGF-beta, and bFGF are present at a very low levels during wound repair in fetal skin. These low levels of growth factors minimize inflammatory response and fibroblast proliferation at the wound site, which in turn inhibit collagen synthesis, and thus, allows scarless wound healing. Recently bone morphogenetic proteins (BMPs), one of the TGF-beta superfamily members, have been studied in the wound healing process. According to several studies, BMPs are related to the differentiation and growth of epithelial and mesenchymal cells, but the precise functions of BMPs and of BMP receptors on skin wound healing have not been elucidated. In this study, we investigated the expression pattern of BMP receptors in fetal skin during the second trimester and in adult skin by immunohistochemical staining and RT-PCR. BMP receptors were detected on the suprabasal epithelial cells and in the hair follicles in adult skin, but were not defected in the fetal skin except for the hair follicles. This was confirmed by confirming mRNA levels of BMP receptors by RT-PCR in both adult and fetal skins. In conclusion, BMPs and BMP receptors seem to be related to fetal and adult wound healing, and low levels of BMPs and BMP receptors during the second trimester seem to contribute to scarless wound healing in the fetus, as is TGF-beta during the second trimester.
journal_name
Yonsei Med Jjournal_title
Yonsei medical journalauthors
Hwang EA,Lee HB,Tark KCdoi
10.3349/ymj.2001.42.6.581keywords:
subject
Has Abstractpub_date
2001-12-01 00:00:00pages
581-6issue
6eissn
0513-5796issn
1976-2437pii
200112581journal_volume
42pub_type
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journal_title:Yonsei medical journal
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journal_title:Yonsei medical journal
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journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.2000.41.2.205
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pub_type: 杂志文章,随机对照试验
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journal_title:Yonsei medical journal
pub_type: 杂志文章
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更新日期:2004-02-29 00:00:00
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journal_title:Yonsei medical journal
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Yonsei medical journal
pub_type: 杂志文章
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更新日期:2019-08-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Yonsei medical journal
pub_type: 杂志文章,评审
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更新日期:2014-07-01 00:00:00
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journal_title:Yonsei medical journal
pub_type: 杂志文章
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更新日期:2005-02-28 00:00:00
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pub_type: 杂志文章,收录出版
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journal_title:Yonsei medical journal
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journal_title:Yonsei medical journal
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pub_type: 杂志文章
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journal_title:Yonsei medical journal
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
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