High-Sensitivity C-Reactive Protein Can Reflect Small Airway Obstruction in Childhood Asthma.

Abstract:

PURPOSE:High-sensitivity assays enabled the identification of C-reactive protein (hs-CRP) at levels that were previously undetectable. We aimed to determine if hs-CRP could reflect airway inflammation in children, by comparing hs-CRP with spirometry and impulse oscillometry (IOS) parameters and symptomatic severities. MATERIALS AND METHODS:A total of 276 asthmatic children who visited Severance Children's Hospital from 2012-2014 were enrolled. Serum hs-CRP and pulmonary function tests were performed on the same day. Patients were divided into hs-CRP positive and negative groups (cut-off value, 3.0 mg/L). RESULTS:Of the 276 asthmatic children [median age 7.5 (5.9/10.1) years, 171 boys (62%)], 39 were hs-CRP positive and 237 were negative. Regarding spirometry parameters, we observed significant differences in maximum mid-expiratory flow, % predicted (FEF₂₅₋₇₅) (p=0.010) between hs-CRP positive and negative groups, and a negative correlation between FEF₂₅₋₇₅ and hs-CRP. There were significant differences in the reactance area (AX) (p=0.046), difference between resistance at 5 Hz and 20 Hz (R5-R20) (p=0.027), resistance at 5 Hz, % predicted (R5) (p=0.027), and reactance at 5 Hz, % predicted (X5) (p=0.041) between hs-CRP positive and negative groups. There were significant positive correlations between hs-CRP and R5 (r=0.163, p=0.008), and X5 (r=0.164, p=0.007). Spirometry and IOS parameters had more relevance in patients with higher blood neutrophil levels in comparison to hs-CRP. CONCLUSION:Hs-CRP showed significant correlation with FEF₂₅₋₇₅, R5, and X5. It can reflect small airway obstruction in childhood asthma, and it is more prominent in neutrophil dominant inflammation.

journal_name

Yonsei Med J

journal_title

Yonsei medical journal

authors

Ko AR,Kim YH,Sol IS,Kim MJ,Yoon SH,Kim KW,Kim KE

doi

10.3349/ymj.2016.57.3.690

subject

Has Abstract

pub_date

2016-05-01 00:00:00

pages

690-7

issue

3

eissn

0513-5796

issn

1976-2437

pii

57.690

journal_volume

57

pub_type

杂志文章
  • Surgical outcome of synchronous second primary cancer in patients with gastric cancer.

    abstract:PURPOSE:In order to improve the likelihood of curative and safe gastric surgery, this study investigated the clinical features and surgical outcomes of gastric cancer with a synchronous cancer. PATIENTS AND METHODS:The clinicopathological data of 10,090 gastric cancer patients at Samsung Medical Center from September ...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2007.48.6.981

    authors: Ha TK,An JY,Youn HG,Noh JH,Sohn TS,Kim S

    更新日期:2007-12-31 00:00:00

  • Long term effects of IUD on the human endometrium. Histologic, histochemical and ultrastructural studies.

    abstract::To evaluate the longterm effects of a IUD on the human endometrium and find the possible contraceptive mechanism of the IUD, histologic, histochemical, and ultrastructural studies of human endometrial biopsies from 44 normal contorls and 178 IUD wearers were made. Histologic findings included interstitial hemorrhage,...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.1983.24.2.141

    authors: Lee YB,Kim CS,Ro JY,Kwak HM,Song CH

    更新日期:1983-01-01 00:00:00

  • RPS15a Silencing Suppresses Cell Proliferation and Migration of Gastric Cancer.

    abstract:PURPOSE:Information on the possible role of the ribosomal protein S15a (RPS15a) in gastric cancer is scarce. The aim of this study was to evaluate the impact of RPS15a gene expression on the growth and cell cycle of gastric cancer cells in vitro and in vivo. MATERIALS AND METHODS:RPS15a mRNA expression was examined in...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2018.59.10.1166

    authors: Shi D,Liu J

    更新日期:2018-12-01 00:00:00

  • Imaging findings of giant liposarcoma of the esophagus.

    abstract::A giant esophageal liposarcoma showing rapid growth over 7 months is presented in 56-year-old man. It originated from the pharyngo-esophageal junction with a short stalk, and extended downward to the distal esophagus. A barium swallow study showed a large, sausage-like intraluminal mass in the dilated esophagus. CT an...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2003.44.4.715

    authors: Chung JJ,Kim MJ,Kim JH,Lee JT,Yoo HS,Kim KW

    更新日期:2003-08-30 00:00:00

  • Current management and future strategies of gastric cancer.

    abstract::The overall prognosis of gastric cancer has gradually improved over the past decades with growing awareness of potential carcinogens, surveillance programs and early diagnosis, as well as advances in surgical techniques and multimodality treatments. Nevertheless, the outcome of advanced stage disease still remains poo...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章,评审

    doi:10.3349/ymj.2012.53.2.248

    authors: Lee JH,Kim KM,Cheong JH,Noh SH

    更新日期:2012-03-01 00:00:00

  • Duration and magnitude of extracellular signal-regulated protein kinase phosphorylation determine adipogenesis or osteogenesis in human bone marrow-derived stem cells.

    abstract:PURPOSE:Imbalances between osteogenic and adipogenic differentiation leads to diseases such as osteoporosis. The aim of our study was to demonstrate the differences in extracellular signal-regulated kinase (ERK) phosphorylation during both adipogenesis and osteogenesis of human bone marrow-derived stem cells (BMSCs). ...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2011.52.1.165

    authors: Jung HS,Kim YH,Lee JW

    更新日期:2011-01-01 00:00:00

  • Autologous platelet-poor plasma gel for injection laryngoplasty.

    abstract:PURPOSE:To overcome the potential disadvantages of the use of foreign materials and autologous fat or collagen, we introduce here an autologous plasma gel for injection laryngoplasty. The purpose of this study was to present a new injection material, a plasma gel, and to discuss its clinical effectiveness. MATERIALS A...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2013.54.6.1516

    authors: Woo SH,Kim JP,Park JJ,Chung PS,Lee SH,Jeong HS

    更新日期:2013-11-01 00:00:00

  • Changes in treatment outcomes of gastric cancer surgery over 45 years at a single institution.

    abstract:PURPOSE:Although many studies have demonstrated improvements in short-and long-term outcomes of gastric cancer surgery, changes in long-term survival over time are not well-established. This study was conducted to evaluate changes in host, tumor, and treatment factors in patients treated at a single institution over a ...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2008.49.3.409

    authors: Hyung WJ,Kim SS,Choi WH,Cheong JH,Choi SH,Kim CB,Noh SH

    更新日期:2008-06-30 00:00:00

  • Endovascular Repair versus Open Repair for Isolated Descending Thoracic Aortic Aneurysm.

    abstract:PURPOSE:To compare the outcomes of thoracic endovascular aortic repair (TEVAR) with those of open repair for descending thoracic aortic aneurysms (DTAA). MATERIALS AND METHODS:We compared the outcomes of 114 patients with DTAA and proximal landing zones 3 or 4 after TEVAR to those of 53 patients after conventional ope...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2015.56.4.904

    authors: Lee HC,Joo HC,Lee SH,Lee S,Chang BC,Yoo KJ,Youn YN

    更新日期:2015-07-01 00:00:00

  • Cytological results of ultrasound-guided fine-needle aspiration cytology for thyroid nodules: emphasis on correlation with sonographic findings.

    abstract:PURPOSE:To compare the cytological results of ultrasound-guided fine-needle aspiration (US-FNA) cytology of thyroid nodules to sonographic findings and determine whether US findings are helpful in the interpretation of cytological results. MATERIALS AND METHODS:Among the thyroid nodules that underwent US-FNA cytology,...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2011.52.5.838

    authors: Lee MJ,Hong SW,Chung WY,Kwak JY,Kim MJ,Kim EK

    更新日期:2011-09-01 00:00:00

  • Combined use of tamoxifen, cyclosporin A, and verapamil for modulating multidrug resistance in human hepatocellular carcinoma cell lines.

    abstract::The intensive use of chemotherapeutic agents for the treatment of cancer has resulted in the cure or improved survival of many patients. But unfortunately, many cancers including human hepatocellular carcinoma (HCC) don't respond to chemotherapy. One of the major mechanisms for the drug resistance in the HCC is an ele...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.1993.34.1.35

    authors: Kim JH,Chung JB,Park IS,Kim BS,Yoo NC,Choi JH,Roh JK,Kim HS,Kwon OH,Lee KS

    更新日期:1993-03-01 00:00:00

  • Effects of seasonal differences in testosterone and cortisol levels on pain responses under resting and anxiety conditions.

    abstract:PURPOSE:This study investigated whether hormones and pain perception are associated with exam anxiety, and also whether exam anxiety is affected by seasonal differences in testosterone and cortisol levels. MATERIALS AND METHODS:Forty-six healthy males were recruited from a medical college. Anxiety was induced by havin...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章,随机对照试验

    doi:10.3349/ymj.2014.55.1.216

    authors: Choi JC,Lee JH,Choi E,Chung MI,Seo SM,Lim HK

    更新日期:2014-01-01 00:00:00

  • Giant Meckel's diverticulum associated with a congenital diaphragmatic hernia.

    abstract::Giant Meckel's diverticulum is a very rare lesion and its association with a congenital diaphragmatic hernia has not been reported previously. We report a case of newborn with a giant Meckel's diverticulum and congenital diaphragmatic hernia. A large round atypical air-filled bowel segment was found by chest radiograp...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2004.45.1.177

    authors: Kang IS,Ahn SM,Han A,Oh JT,Han SJ,Choi SH,Hwang EH

    更新日期:2004-02-29 00:00:00

  • New insights in the clinical understanding of Behçet's disease.

    abstract::Behçet's disease is a chronic relapsing multisystemic inflammatory disorder characterized by four major symptoms (oral aphthous ulcers, genital ulcers, skin lesions, and ocular lesions) and occasionally by five minor symptoms (arthritis, gastrointestinal ulcers, epididymitis, vascular lesions, and central nervous syst...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2012.53.1.35

    authors: Cho SB,Cho S,Bang D

    更新日期:2012-01-01 00:00:00

  • Significance of fracture gap in open tibial fracture.

    abstract::The healing pattern of medial and lateral cortical gap in open transverse or short oblique tibial fractures were retrospectively reviewed in 2 groups; In group A, 16 patients were treated by Judet external fixator in rigid mode. In group B, 6 patients were treated in biocompressive mode, which allowed predominantly lo...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.1995.36.2.130

    authors: Yang KH,Patel A

    更新日期:1995-05-01 00:00:00

  • Asymptomatic electrophysiologic carpal tunnel syndrome in diabetics: entrapment or polyneuropathy.

    abstract::Electrophysiologic carpal tunnel syndrome (CTS) is common and is frequently asymptomatic in diabetics. In order to evaluate the clinical significance of asymptomatic electrophysiologic CTS, the nerve conduction studies (NCS) of 48 diabetics with asymptomatic electrophysiologic CTS were compared with those of 56 age an...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2000.41.1.123

    authors: Kim WK,Kwon SH,Lee SH,Sunwoo IN

    更新日期:2000-02-01 00:00:00

  • Silicon dioxide particles deposited in vessels and cartilage of the femoral head.

    abstract::Silicosis had been considered for decades as an illness with manifestations of lung fibrosis due to inhalation of overconcentrated SiO₂ dust. To the best of our knowledge, studies have yet to report SiO₂ deposits in any other tissues and organs. In the present case, while performing bilateral artificial total hip arth...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2014.55.5.1447

    authors: Xu M,Qing M,Peng D

    更新日期:2014-09-01 00:00:00

  • Localized resectable genitourinary sarcoma in adult Korean patients: experiences at a single center.

    abstract:PURPOSE:To evaluate the clinicopathological characteristics and prognosis of localized resectable genitourinary sarcomas in adults. MATERIALS AND METHODS:Between September, 1996 and November, 2008, 18 consecutive cases of adults (12 men and 6 women; median age 48.8 years) who were treated for primary genitourinary sar...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2011.52.5.761

    authors: Cho SY,Moon KC,Cheong MS,Kwak C,Kim HH,Ku JH

    更新日期:2011-09-01 00:00:00

  • Silencing of LncRNA-ANCR Promotes the Osteogenesis of Osteoblast Cells in Postmenopausal Osteoporosis via Targeting EZH2 and RUNX2.

    abstract:PURPOSE:This study aimed to explore the effects and mechanisms of long non-coding RNA (lncRNA) anti-differentiation non-coding RNA (ANCR) on the osteogenesis of osteoblast cells in postmenopausal osteoporosis (PMOP). MATERIALS AND METHODS:Mice models of PMOP were established. ANCR expression and intracellular calcium ...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2019.60.8.751

    authors: Cai N,Li C,Wang F

    更新日期:2019-08-01 00:00:00

  • Experiences of the Emergency Department at the Pyeongchang Polyclinic During the 2018 PyeongChang Winter Olympic Games.

    abstract:PURPOSE:The 2018 PyeongChang Winter Olympic Games involved 2925 elite athletes, and providing proper health care services for these elite athletes was a critical priority. We established an emergency department (ED) in the Pyeongchang Mountain Polyclinic during the Olympics, which served staff and athletes from many co...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2019.60.5.474

    authors: Kim K,Jang JY,Moon G,Shim H,Jung PY,Kim S,Choi YU,Bae KS

    更新日期:2019-05-01 00:00:00

  • The effects of different noise types on heart rate variability in men.

    abstract:PURPOSE:To determine the impact of noise on heart rate variability (HRV) in men, with a focus on the noise type rather than on noise intensity. MATERIALS AND METHODS:Forty college-going male volunteers were enrolled in this study and were randomly divided into four groups according to the type of noise they were expos...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2015.56.1.235

    authors: Sim CS,Sung JH,Cheon SH,Lee JM,Lee JW,Lee J

    更新日期:2015-01-01 00:00:00

  • Identification of Tyrophagus putrescentiae allergens and evaluation of cross-reactivity with Dermatophagoides pteronyssinus.

    abstract::House dust mites are the most common cause of allergic sensitization in respiratory allergic patients in the world. Tyrophagus putrescentiae (TP), which was followed by Dermatophagoides farinae (DF) and Dermatophagoides pteronyssinus (DP), has been reported as the third most common house mite in Korea. We previously r...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.1998.39.2.109

    authors: Munhbayarlah S,Park JW,Ko SH,Ree HI,Hong CS

    更新日期:1998-04-01 00:00:00

  • Entecavir to Telbivudine Switch Therapy in Entecavir-Treated Patients with Undetectable Hepatitis B Viral DNA.

    abstract:PURPOSE:This study examined 2-year outcome of consecutive therapy using entecavir (ETV) followed by telbivudine (LdT) in subjects with undetectable hepatitis B virus (HBV) DNA level and normal alanine aminotransferase level after the initial 6 months of ETV treatment. MATERIALS AND METHODS:Sixty subjects were randomiz...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章,随机对照试验

    doi:10.3349/ymj.2017.58.3.552

    authors: Kim DH,Choi JW,Seo JH,Cho YS,Won SY,Park BK,Jeon HH,Shin SY,Lee CK

    更新日期:2017-05-01 00:00:00

  • Endothelial dysfunction and alteration of nitric oxide/ cyclic GMP pathway in patients with exercise-induced hypertension.

    abstract::The diagnostic and prognostic implication of exaggerated blood pressure response to exercise have been controversial, with opinions ranging from a benign process to a harbinger of potential cardiovascular morbidity. Endothelial dysfunction has been demonstrated in patients with atherosclerosis and as a risk factor for...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2003.44.6.1014

    authors: Chang HJ,Chung JH,Choi BJ,Choi TY,Choi SY,Yoon MH,Hwang GS,Shin JH,Tahk SJ,Choi BI

    更新日期:2003-12-30 00:00:00

  • Extradural approach to the lateral sellar compartment.

    abstract::This paper describes an extradural approach to the lateral sellar compartment (LSC, cavernous sinus), which represents a refinement of the original work performed on this topic by Parkinson, Dolenc, and Hakuba, and other enthusiastic neurosurgeons. This detailed description of the extradural approach is based on the d...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2001.42.1.120

    authors: Lee KS

    更新日期:2001-02-01 00:00:00

  • Association between fecal bile acids and colorectal cancer: a meta-analysis of observational studies.

    abstract:PURPOSE:To provide a systematic review with meta-analysis for addressing the relationship between fecal bile acids (FBAs) and colorectal cancer. MATERIALS AND METHODS:Electronic databases were searched for all observational studies that examined the relationship between FBAs and colorectal cancer or adenoma, and calcu...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章,meta分析

    doi:10.3349/ymj.2008.49.5.792

    authors: Tong JL,Ran ZH,Shen J,Fan GQ,Xiao SD

    更新日期:2008-10-31 00:00:00

  • Sensory neuronal change after intravesical electrical stimulation in spinailized rat.

    abstract::The clinical benefits of intravesical electrical stimulation (IVES) in patients with increased residual urine or reduced bladder capacity have been reported. However, studies on the underlying mechanism of IVES has been limited to the Adelta afferent and parasympathetic neurons. This study investigated the changes in ...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2002.43.5.652

    authors: Hong CH,Kim JH,Noh JY,Gil YC,Lee HY,Lee WH,Han SW

    更新日期:2002-10-01 00:00:00

  • Promoter methylation in the genesis of gastrointestinal cancer.

    abstract::Colorectal cancers (CRC)--and probably all cancers--are caused by alterations in genes. This includes activation of oncogenes and inactivation of tumor suppressor genes (TSGs). There are many ways to achieve these alterations. Oncogenes are frequently activated by point mutation, gene amplification, or changes in the ...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章,评审

    doi:10.3349/ymj.2009.50.3.309

    authors: Boland CR,Shin SK,Goel A

    更新日期:2009-06-30 00:00:00

  • Clinical usefulness of magnetic resonance cisternography in patients having hemifacial spasm.

    abstract::To evaluate the usefulness of MR cisternography fourteen patients that had hemifacial spasm and 20 control patients underwent MR cisternography. All the patients with hemifacial spasm had a confirmed vascular compression after surgery. MR cisternography was performed using a 1.5-tesla superconducting MR magnet in whic...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2001.42.4.390

    authors: Lee MS,Kim MS,Hong IS,Whang K,Han YP

    更新日期:2001-08-01 00:00:00

  • Conservative treatment in intra-articular fractures of the distal radius: a study on the functional and anatomic outcome in elderly patients.

    abstract::Fractures of the distal radius are common among elderly patients. Although the indications for surgical treatment are clearly defined, there are patients who will not consent to an operation, even when it is indicated. Inevitably, these cases will require conservative treatment. The aim of this study was to determine ...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2003.44.5.836

    authors: Dayican A,Unal VS,Ozkurt B,Portakal S,Nuhoglu E,Tumoz MA

    更新日期:2003-10-30 00:00:00