Entecavir to Telbivudine Switch Therapy in Entecavir-Treated Patients with Undetectable Hepatitis B Viral DNA.

Abstract:

PURPOSE:This study examined 2-year outcome of consecutive therapy using entecavir (ETV) followed by telbivudine (LdT) in subjects with undetectable hepatitis B virus (HBV) DNA level and normal alanine aminotransferase level after the initial 6 months of ETV treatment. MATERIALS AND METHODS:Sixty subjects were randomized to continue with ETV or switch to LdT. Significant difference in baseline characteristics was not found between the two groups. Persistent HBV DNA level of 20-60 IU/mL in three consecutive samples collected three months apart or singly measured HBV DNA level of >60 IU/mL was defined as virological rebound. RESULTS:During 96 weeks of follow-up, all subjects of the ETV-only group (n=30) resulted in undetectable HBV DNA level. On the other hand, 83.3% (n=25) of the LdT-switched group showed treatment success. Virological rebound time varied from week 24 to 84 after switching to LdT. HBV DNA level was 180 to 2940 IU/mL at rebound time. All subjects with virological rebound (n=5) showed drug-resistant mutation: three had mutation rtM204I, and two had mutation rtM204V. Consecutive treatment using ETV followed by LdT showed virological rebound in 16.7% of subjects during 96 weeks of follow-up. HBV DNA negativity during initial ETV therapy could not be achieved in patients who switched to LdT. CONCLUSION:Consecutive treatment using ETV followed by lamivudine was ineffective for treating chronic hepatitis B. LdT was found as a more potent antiviral agent than lamivudine. However, this conclusion requires larger-scale, long-term prospective reviews of the treatment effects of ETV-LdT switch therapy.

journal_name

Yonsei Med J

journal_title

Yonsei medical journal

authors

Kim DH,Choi JW,Seo JH,Cho YS,Won SY,Park BK,Jeon HH,Shin SY,Lee CK

doi

10.3349/ymj.2017.58.3.552

subject

Has Abstract

pub_date

2017-05-01 00:00:00

pages

552-556

issue

3

eissn

0513-5796

issn

1976-2437

pii

58.552

journal_volume

58

pub_type

杂志文章,随机对照试验
  • Intraoperative adjustment in strabismus surgery under topical anesthesia.

    abstract::We evaluated the one-stage intraoperative adjustment strabismus surgery with adjustable suture under topical anesthesia. Medical records of the patients who had intraoperative adjustment surgery under topical anesthesia for horizontal or vertical strabismus in our hospital from March 1997 to March 2003 with follow-up ...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2006.47.5.667

    authors: Chang YH,Ryu IH,Han SH,Lee SJ,Lee JB

    更新日期:2006-10-31 00:00:00

  • The Effects of Short-Term and Very Short-Term Particulate Matter Exposure on Asthma-Related Hospital Visits: National Health Insurance Data.

    abstract:PURPOSE:The purpose of this study was to investigate the effects of short-term and very short-term exposure to particulate matter (PM) exceeding the daily average environmental standards for Korea (≤100 μg/m³ for PM10 and ≤50 μg/m³ for PM2.5) on on asthma-related hospital visits. MATERIALS AND METHODS:This was a popul...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2019.60.10.952

    authors: Song DJ,Choi SH,Song WJ,Park KH,Jee YK,Cho SH,Lim DH

    更新日期:2019-10-01 00:00:00

  • Effect of an air cleaner with electrostatic filter on the removal of airborne house dust mite allergens.

    abstract:PURPOSE:The effects of air cleaners on the removal of airborne indoor allergens, especially house dust mites (HDM), are still controversial. The objective of this study is to evaluate the effect of an air cleaner with an electrostatic filter on the removal of airborne mite allergens. MATERIALS AND METHODS:A dried HDM ...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2010.51.6.918

    authors: Agrawal SR,Kim HJ,Lee YW,Sohn JH,Lee JH,Kim YJ,Lee SH,Hong CS,Park JW

    更新日期:2010-11-01 00:00:00

  • Determinants of one-year response of lumbar bone mineral density to alendronate treatment in elderly Japanese women with osteoporosis.

    abstract::The purpose of this study was to determine factors that could predict the one-year response of the lumbar bone mineral density (BMD) to alendronate treatment in elderly Japanese women with osteoporosis. Eighty-five postmenopausal women with osteoporosis, all of whom were between 55-88 years of age, were treated with a...

    journal_title:Yonsei medical journal

    pub_type: 临床试验,杂志文章

    doi:10.3349/ymj.2004.45.4.676

    authors: Iwamoto J,Takeda T,Sato Y,Uzawa M

    更新日期:2004-08-31 00:00:00

  • An evaluation of glucose tolerance in essential hypertension.

    abstract:PURPOSE:This study aimed to determine the impaired glucose tolerance and diabetes prevalence in patients with essential hypertension (HT) and to compare the developed microvascular complications of these groups. MATERIALS AND METHODS:An oral glucose tolerance test (OGTT) was performed on 338 essential hypertensive cas...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2009.50.2.195

    authors: Tugrul A,Guldiken S,Ugur-Altun B,Arikan E

    更新日期:2009-04-30 00:00:00

  • Percutaneous cardiopulmonary support in refractory no-reflow with cardiogenic shock after coronary stenting in acute myocardial infarction.

    abstract::Coronary no-reflow is defined as inadequate myocardial perfusion of a given coronary segment without angiographic evidence of mechanical vessel obstruction. No-reflow is visualized angiographically as a reduction in thrombolysis in myocardial infarction (TIMI) flow grade and is typically accompanied by chest pain, ele...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2010.51.4.599

    authors: Son JW,Kim JS,Lee JM,Hong SJ,Jung MK,Kim DH,Kim JS,Choi D,Jang Y

    更新日期:2010-07-01 00:00:00

  • Left Ventricular End-Systolic Volume Can Predict 1-Year Hierarchical Clinical Composite End Point in Patients with Cardiac Resynchronization Therapy.

    abstract:PURPOSE:This study aimed to elucidate which echocardiographic criteria at three time points, for cardiac resynchronization therapy (CRT) response, are accurate in discriminating the hierarchical clinical composite end point (HCCEP). MATERIALS AND METHODS:We included 120 patients (age, 66.1±12.6 years; men, 54.2%) who ...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2019.60.1.48

    authors: Uhm JS,Oh J,Cho IJ,Park M,Kim IS,Jin MN,Bae HJ,Yu HT,Kim TH,Pak HN,Lee MH,Joung B,Kang SM

    更新日期:2019-01-01 00:00:00

  • miR-140-3p Knockdown Suppresses Cell Proliferation and Fibrogenesis in Hepatic Stellate Cells via PTEN-Mediated AKT/mTOR Signaling.

    abstract:PURPOSE:Liver fibrosis is a major cause of morbidity and mortality and the outcome of various chronic liver diseases. Activation of hepatic stellate cells (HSCs) is the key event in liver fibrosis. Studies have confirmed that miR-140-3p plays a potential regulatory effect on HSC activation. However, whether miR-140-3p ...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2019.60.6.561

    authors: Wu SM,Li TH,Yun H,Ai HW,Zhang KH

    更新日期:2019-06-01 00:00:00

  • A Single-Center, Retrospective Study of Bevacizumab-Containing Neoadjuvant Chemotherapy followed by Interval Debulking Surgery for Ovarian Cancer.

    abstract:PURPOSE:We evaluated whether adding bevacizumab to current platinum-based chemotherapy could improve clinical outcomes without affecting safety. MATERIALS AND METHODS:We retrospectively reviewed medical records of patients with pathologically confirmed ovarian cancer who received neoadjuvant chemotherapy (NAC) at Yons...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2020.61.4.284

    authors: Park J,Eoh KJ,Nam EJ,Kim S,Kim SW,Kim YT,Lee JY

    更新日期:2020-04-01 00:00:00

  • Posterior lumbar interbody fusion via a unilateral approach.

    abstract::This study sought to determine the outcomes of posterior lumbar interbody fusion (PLIF), via a unilateral approach, in selected patients who presented with unilateral leg pain and segmental instability of the lumbar spine. Patients with a single level of a herniated disc disease in the lumbar spine, unilateral leg pai...

    journal_title:Yonsei medical journal

    pub_type: 临床试验,杂志文章

    doi:10.3349/ymj.2006.47.3.319

    authors: Shin HC,Yi S,Kim KN,Kim SH,Yoon DH

    更新日期:2006-06-30 00:00:00

  • Endoscopic laser surgery for subglottic stenosis in Wegener's granulomatosis.

    abstract:PURPOSE:Wegener's granulomatosis (WG) is a rare multisystem inflammatory disease, which infrequently involves the subglottic area and trachea. Treatment usually involves the use of immunosuppressive agents with corticosteroids. Some patients, however, continue to have symptoms of airway obstruction after clinical remis...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2007.48.5.748

    authors: Shvero J,Shitrit D,Koren R,Shalomi D,Kramer MR

    更新日期:2007-10-31 00:00:00

  • Minimal stimulation using gonadotropin combined with clomiphene citrate or letrozole for intrauterine insemination.

    abstract:PURPOSE:To evaluate the efficacy of minimal stimulation using discretely administered gonadotropin combined with clomiphene citrate (CC) or letrozole (LTZ) for intrauterine insemination (IUI) cycles. MATERIALS AND METHODS:Total 257 IUI cycles from 158 infertile couples were assessed. A CC dose of 100 mg/day (n=126 cyc...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2015.56.2.490

    authors: Yun BH,Chon SJ,Park JH,Seo SK,Cho S,Choi YS,Kim SH,Lee BS

    更新日期:2015-03-01 00:00:00

  • Microsatellite marker in gamma - aminobutyric acid - a receptor beta 3 subunit gene and autism spectrum disorders in Korean trios.

    abstract::This study aimed to identify the association between gamma-aminobutyric acid-A (GABA-A) receptor subunit beta3 (GABRB3) gene and autism spectrum disorders (ASD) in Korea. Fifty-eight children with ASD [47 boys (81.0%), 5.5 +/- 4.1 years old], 46 family trios, and 86 healthy control subjects [71 males (82.6%), 33.6 +/-...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2009.50.2.304

    authors: Yoo HK,Chung S,Hong JP,Kim BN,Cho SC

    更新日期:2009-04-30 00:00:00

  • Pharmacokinetic modeling of phagocytic activity of the liver using superparamagnetic iron oxide nanoparticles in dynamic MR imaging.

    abstract::The purpose of this study was to determine whether phagocytic activity is measurable by dynamic superparamagnetic iron oxide-enhanced MR imaging. For these experiments on New Zealand White rabbits, which were randomly allocated to normal and silica treated groups, we performed a dynamic MR study and radioisotope study...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2003.44.3.429

    authors: Na JB,Suh JS,Huh YM,Kim SJ,Kim SH,Cha SH,Lee SH

    更新日期:2003-06-30 00:00:00

  • Strategies to improve dendritic cell-based immunotherapy against cancer.

    abstract::Dendritic cells (DCs) play a pivotal role in T cell-mediated immunity and have been shown to induce strong antitumor immune responses in vitro and in vivo. Various approaches utilizing different vaccine cell formats, cell numbers, vaccination schedule, site of vaccination and maturation stages of DCs were investigated...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章,评审

    doi:10.3349/ymj.2004.45.Suppl.48

    authors: Song SY,Kim HS

    更新日期:2004-06-30 00:00:00

  • Neonatal outcome after preterm delivery in HELLP syndrome.

    abstract::The present study compares neonatal outcome after preterm delivery of infants in pregnancies complicated by the HELLP syndrome or severe preeclampsia (PS). The maternal and neonatal charts of 71 out of a total of 409 pregnancies that were complicated by hypertensive disorders at Severance hospital between January 1995...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2006.47.3.393

    authors: Kim HY,Sohn YS,Lim JH,Kim EH,Kwon JY,Park YW,Kim YH

    更新日期:2006-06-30 00:00:00

  • Correlation between EGFR and c-erbB-2 oncoprotein status and response to neoadjuvant chemotherapy in cervical carcinoma.

    abstract::Neoadjuvant chemotherapy prior to definitive radical surgery or radiotherapy may be effective in reducing tumor volume or clinical stage and may even enhance pelvic control and survival. However, there are significant limitations to the use of neoadjuvant therapy in the non-responder group. They include delayed total ...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.1999.40.3.207

    authors: Kim JW,Kim YT,Kim DK

    更新日期:1999-06-01 00:00:00

  • Graves' disease associated with Klinefelter's syndrome.

    abstract::Klinefelter's syndrome is one of the most common forms of primary hypogonadism and infertility in males. It is characterized by small and firm testes, gynecomastia, azoospermia, and an elevated gonadotropin level. The frequencies of diabetes mellitus, breast cancer, and germ cell neoplasia increases in Klinefelter's s...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2004.45.2.341

    authors: Park JS,Kim CS,Nam JY,Kim DM,Yoon SJ,Ahn CW,Cha BS,Lim SK,Kim KR,Lee HC,Huh KB

    更新日期:2004-04-30 00:00:00

  • Differentiation between reinfection and recrudescence of helicobacter pylori strains using PCR-based restriction fragment length polymorphism analysis.

    abstract::The aim of this study was to evaluate whether PCR-based restriction fragment length polymorphism (RFLP) analysis was effective in differentiating between reinfection and recrudescence of H. pylori strains. Following a 1-2 week regimen of omeprazole 20 mg, amoxicillin 1.0 g, and clarithromycin 500 mg twice daily, twent...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2001.42.1.41

    authors: Jeen YT,Lee SW,Kwon SI,Chun HJ,Lee HS,Song CW,Um SH,Choi JH,Kim CD,Ryu HS,Hyun JH

    更新日期:2001-02-01 00:00:00

  • Extracting extra-telomeric phenotypes from telomerase mouse models.

    abstract::Telomerase reverse transcriptase (TERT) is the protein component of telomerase and combined with an RNA molecule, telomerase RNA component, forms the telomerase enzyme responsible for telomere elongation. Telomerase is essential for maintaining telomere length from replicative attrition and thus contributes to the pre...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章,评审

    doi:10.3349/ymj.2014.55.1.1

    authors: Sung YH,Ali M,Lee HW

    更新日期:2014-01-01 00:00:00

  • Production of egg yolk antibodies specific to house dust mite proteins.

    abstract:PURPOSE:House dust mites (HDMs) are an important source of indoor allergens associated with asthma, rhinitis and atopic dermatitis. Chicken immunoglobulin (Ig) Y is known to be a good alternative to mice and rabbit antibody production. In this study, we produced IgYs specific to HDMs and investigated their IgE immunore...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2014.55.4.999

    authors: Lee KE,Han BK,Han JY,Hong JY,Kim MN,Heo WI,Sohn MH,Kim KW,Kim KE

    更新日期:2014-07-01 00:00:00

  • Effect of long-term hormone therapy on telomere length in postmenopausal women.

    abstract::Telomeres undergo attrition with each cell division, and telomere length is associated with age-related diseases and mortality in the elderly. Estrogen can influence the attrition of telomeres by diverse mechanisms. This is a retrospective case control study that investigated the influence of long-term hormone therapy...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2005.46.4.471

    authors: Lee DC,Im JA,Kim JH,Lee HR,Shim JY

    更新日期:2005-08-31 00:00:00

  • Changes in treatment outcomes of gastric cancer surgery over 45 years at a single institution.

    abstract:PURPOSE:Although many studies have demonstrated improvements in short-and long-term outcomes of gastric cancer surgery, changes in long-term survival over time are not well-established. This study was conducted to evaluate changes in host, tumor, and treatment factors in patients treated at a single institution over a ...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2008.49.3.409

    authors: Hyung WJ,Kim SS,Choi WH,Cheong JH,Choi SH,Kim CB,Noh SH

    更新日期:2008-06-30 00:00:00

  • Whole blood interferon-γ release assay is insufficient for the diagnosis of sputum smear negative pulmonary tuberculosis.

    abstract:PURPOSE:We investigated the value of an interferon-γ release assay (IGRA) for the diagnosis of active pulmonary tuberculosis (PTB) among sputum smear negative PTB suspects in an environment with intermediate burden of PTB and high Bacillus Calmette-Guerin (BCG) vaccination rate. MATERIALS AND METHODS:We retrospectivel...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2014.55.3.725

    authors: Park H,Shin JA,Kim HJ,Ahn CM,Chang YS

    更新日期:2014-05-01 00:00:00

  • Implication of early lymphocyte recovery after allogeneic hematopoietic stem cell transplantation in children with leukemia.

    abstract:PURPOSE:The repopulating lymphocytes after allogeneic hematopoietic stem cell transplantation have an important role not only on the prevention of serious infections in the early transplantation period, but also on the killing of residual leukemic cells by graft-versus-leukemia effect. The aim of this study was to anal...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2013.54.1.62

    authors: Han DK,Baek HJ,Kim SY,Hwang TJ,Kook H

    更新日期:2013-01-01 00:00:00

  • Disturbed eating attitudes and behaviors in South Korean boys and girls: a school-based cross-sectional study.

    abstract:PURPOSE:This study was designed to assess the prevalence and correlates of disturbed eating attitudes and behaviors in South Korean students. MATERIALS AND METHODS:In a cross-sectional survey, 2,226 fourth and seventh grade students filled out questionnaires on eating attitudes and behaviors (Eating Attitude Test -26,...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2010.51.3.302

    authors: Yang SJ,Kim JM,Yoon JS

    更新日期:2010-05-01 00:00:00

  • Troglitazone Enhances the Apoptotic Response of DLD-1 Colon Cancer Cells to Photodynamic Therapy.

    abstract:PURPOSE:The aim of this study was to investigate whether the peroxisomal proliferator-activated receptor gamma (PPARγ) ligand troglitazone in combination with photodynamic therapy (PDT) enhances the apoptotic response of DLD-1 colon cancer cells. MATERIALS AND METHODS:The effects of troglitazone, PDT, and troglitazone...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2016.57.6.1494

    authors: Park H,Ko SH,Lee JM,Park JH,Choi YH

    更新日期:2016-11-01 00:00:00

  • Sensory neuronal change after intravesical electrical stimulation in spinailized rat.

    abstract::The clinical benefits of intravesical electrical stimulation (IVES) in patients with increased residual urine or reduced bladder capacity have been reported. However, studies on the underlying mechanism of IVES has been limited to the Adelta afferent and parasympathetic neurons. This study investigated the changes in ...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2002.43.5.652

    authors: Hong CH,Kim JH,Noh JY,Gil YC,Lee HY,Lee WH,Han SW

    更新日期:2002-10-01 00:00:00

  • Diagnostic value of insulin-like growth factor-I in short stature.

    abstract::For the present, to determine growth hormone(GH) deficiency in patients with short stature, many provocative tests using various pharmacological agents such as glucagon, insulin, clonidine, arginine, growth hormone releasing factor, etc. should be done. These are not only complicated but are also misleading in some pa...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.1989.30.4.367

    authors: Park MS,Kim DH

    更新日期:1989-12-01 00:00:00

  • Tissue engineering applications in the genitourinary tract system.

    abstract::The concept of cell transplantation using tissue engineering techniques has provided numerous possibilities in the area of urologic tissue reconstruction. Tissue engineering applications in the genitourinary tract system have been investigated in almost every tissue in order to improve, restore and replace existing ti...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章,评审

    doi:10.3349/ymj.2000.41.6.789

    authors: Yoo JJ,Atala A

    更新日期:2000-12-01 00:00:00