Left Ventricular End-Systolic Volume Can Predict 1-Year Hierarchical Clinical Composite End Point in Patients with Cardiac Resynchronization Therapy.


PURPOSE:This study aimed to elucidate which echocardiographic criteria at three time points, for cardiac resynchronization therapy (CRT) response, are accurate in discriminating the hierarchical clinical composite end point (HCCEP). MATERIALS AND METHODS:We included 120 patients (age, 66.1±12.6 years; men, 54.2%) who underwent CRT implantation for heart failure (HF). Echocardiography was performed before and at 3, 6, and 12 months after CRT implantation. The 1-year HCCEP included all-cause mortality, hospitalization for HF, and New York Heart Association functional class for 12 months. CRT response criteria were decrease in left ventricular (LV) end-systolic volume (LVESV) >15%, decrease in LV end-diastolic volume >15%, absolute increase in LV ejection fraction (LVEF) ≥5%, relative increase in LVEF ≥15%, and decrease in mitral regurgitation ≥1 grade. Temporal changes in CRT response rates, accuracy of CRT response criteria at each time and cutoff value for the discrimination of improvement in HCCEP, and agreements with improvement in HCCEP were analyzed. RESULTS:HCCEP improvement rates were 65.8% in total group. In nonischemic group, CRT response rates according to all echocardiographic criteria significantly increased with time. In ischemic group, CRT response rate did not significantly change with time. In total group, ΔLVESV at 6 months (ΔLVESV6) had the most significant accuracy for the discrimination of HCCEP (area under the curve=0.781). The optimal cutoff value of ΔLVESV6 was 13.5% (sensitivity=0.719, specificity=0.719). ΔLVESV6 had fair agreement with HCCEP (κ=0.391, p<0.001). CONCLUSION:ΔLVESV6 is the most useful echocardiographic CRT response criterion for the prediction of 1-year HCCEP.


Yonsei Med J


Yonsei medical journal


Uhm JS,Oh J,Cho IJ,Park M,Kim IS,Jin MN,Bae HJ,Yu HT,Kim TH,Pak HN,Lee MH,Joung B,Kang SM




Has Abstract


2019-01-01 00:00:00














  • Coronary-subclavian steal syndrome presenting with ventricular tachycardia.

    abstract::Coronary-subclavian steal through the left internal mammary graft is a rare cause of myocardial ischemia in patients who have had a coronary bypass surgery. We report a 70-year-old man who presented with sustained monomorphic ventricular tachycardia 5 years after the surgical creation of a left internal mammary to the...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章


    authors: Kursaklioglu H,Kose S,Iyisoy A,Amasyali B,Celik T,Aytemir K,Isik E

    更新日期:2009-12-31 00:00:00

  • Long-term clinical and angiographic outcomes of wrap-clipping strategies for unclippable cerebral aneurysms.

    abstract:PURPOSE:To evaluate the efficacy and stability of the wrap-clipping methods as a reconstructive strategy in the treatment of unclippable cerebral aneurysms. MATERIALS AND METHODS:Twenty four patients who had undergone wrap-clipping microsurgery were retrospectively reviewed. Type and morphology of the treated aneurysm...

    journal_title:Yonsei medical journal

    pub_type: 临床试验,杂志文章


    authors: Kim YB,Hong CK,Chung J,Joo JY,Huh SK

    更新日期:2014-03-01 00:00:00

  • Factors Influencing Outcomes after Ulnar Nerve Stability-Based Surgery for Cubital Tunnel Syndrome: A Prospective Cohort Study.

    abstract:PURPOSE:Simple decompression of the ulnar nerve has outcomes similar to anterior transposition for cubital tunnel syndrome; however, there is no consensus on the proper technique for patients with an unstable ulnar nerve. We hypothesized that 1) simple decompression or anterior ulnar nerve transposition, depending on n...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章


    authors: Kang HJ,Oh WT,Koh IH,Kim S,Choi YR

    更新日期:2016-03-01 00:00:00

  • A pilot study of calcineurin inhibitors (CNIs) and steroid avoidance immunosuppressive protocol among living donor kidney transplant recipients.

    abstract::Calcineurin Inhibitors (CNIs) and Corticosteroids have been the main immunosuppressive agents in solid organ transplantation. Many studies have confirmed the positive impacts of withdrawal/avoidance of these agents, separately, on their side effect profiles. A pilot study was performed avoiding both agents among low-i...

    journal_title:Yonsei medical journal

    pub_type: 临床试验,杂志文章


    authors: Oh HK,Ding P,Satmary NA

    更新日期:2004-12-31 00:00:00

  • All-Trans Retinoic Acid Synergizes with Enasidenib to Induce Differentiation of IDH2-Mutant Acute Myeloid Leukemia Cells.

    abstract:PURPOSE:Pharmacological inhibition of mutant isocitrate dehydrogenase (IDH) reduces R-2-hydroxyglutarate (2-HG) levels and restores cellular differentiation in vivo and in vitro. The IDH2 inhibitor enasidenib (AG-221) has been approved by the FDA as a first-in-class inhibitor for the treatment of relapsed or refractory...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章


    authors: Kim Y,Jeung HK,Cheong JW,Song J,Bae SH,Lee JI,Min YH

    更新日期:2020-09-01 00:00:00

  • Posterior ligamentous complex injuries are related to fracture severity and neurological damage in patients with acute thoracic and lumbar burst fractures.

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    journal_title:Yonsei medical journal

    pub_type: 杂志文章


    authors: Machino M,Yukawa Y,Ito K,Kanbara S,Morita D,Kato F

    更新日期:2013-07-01 00:00:00

  • Diagnostic algorithm to reflect regressive changes of human papilloma virus in tissue biopsies.

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    journal_title:Yonsei medical journal

    pub_type: 杂志文章


    authors: Lhee MJ,Cha YJ,Bae JM,Kim YT,Cho NH

    更新日期:2014-03-01 00:00:00

  • C-Reactive Protein to Serum Albumin Ratio Is an Independent Predictor of All-Cause Mortality in Patients with ANCA-Associated Vasculitis.

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    journal_title:Yonsei medical journal

    pub_type: 杂志文章


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    更新日期:2018-09-01 00:00:00

  • Carriage rates and serogroups of Neisseria meningitidis among freshmen in a University dormitory in Korea.

    abstract:PURPOSE:Neisseria meningitidis is a leading cause of bacterial meningitis in young adults. University students, especially those living in dormitories, have been known to be at increased risk of meningococcal disease. We performed a longitudinal study to determine the carriage rates of N. meningitidis and the changes t...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章


    authors: Durey A,Bae SM,Lee HJ,Nah SY,Kim M,Baek JH,Kang YH,Chung MH,Lee JS

    更新日期:2012-07-01 00:00:00

  • Effects of seasonal differences in testosterone and cortisol levels on pain responses under resting and anxiety conditions.

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    journal_title:Yonsei medical journal

    pub_type: 杂志文章,随机对照试验


    authors: Choi JC,Lee JH,Choi E,Chung MI,Seo SM,Lim HK

    更新日期:2014-01-01 00:00:00

  • Comparison of the efficacy and safety of sodium phosphate tablets and polyethylene glycol solution for bowel cleansing in healthy Korean adults.

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    journal_title:Yonsei medical journal

    pub_type: 杂志文章,随机对照试验


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    更新日期:2014-11-01 00:00:00

  • Histological studies of surgically resected hepatocellular carcinoma following combined radiotherapy and hyperthermia.

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    journal_title:Yonsei medical journal

    pub_type: 杂志文章


    authors: Seong JS,Han EK,Han KH,Noh SH,Park CI,Loh JJ,Choi HJ

    更新日期:1991-06-01 00:00:00

  • Alcoholism prevalence and some related factors in Edirne, Turkey.

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    journal_title:Yonsei medical journal

    pub_type: 杂志文章


    authors: Ekuklu G,Deveci S,Eskiocak M,Berberoglu U,Saltik A

    更新日期:2004-04-30 00:00:00

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    pub_type: 杂志文章


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    journal_title:Yonsei medical journal

    pub_type: 杂志文章,评审


    authors: Jeong E,Lee JY

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    journal_title:Yonsei medical journal

    pub_type: 已发布勘误



    更新日期:2017-09-01 00:00:00

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    pub_type: 临床试验,杂志文章,多中心研究


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    journal_title:Yonsei medical journal

    pub_type: 杂志文章


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    journal_title:Yonsei medical journal

    pub_type: 杂志文章


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    journal_title:Yonsei medical journal

    pub_type: 杂志文章


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    journal_title:Yonsei medical journal

    pub_type: 杂志文章


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    journal_title:Yonsei medical journal

    pub_type: 杂志文章


    authors: Shim CN,Chung MJ,Bang S,Park SW,Song SY,Chung JB,Park JY

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    journal_title:Yonsei medical journal

    pub_type: 杂志文章


    authors: Kim GW,Sohn YH,Huh K,Kim JS

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    journal_title:Yonsei medical journal

    pub_type: 杂志文章


    authors: Shim JY,Kim TS

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    journal_title:Yonsei medical journal

    pub_type: 杂志文章,评审


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