Abstract：
PURPOSE:We evaluated whether adding bevacizumab to current platinum-based chemotherapy could improve clinical outcomes without affecting safety. MATERIALS AND METHODS:We retrospectively reviewed medical records of patients with pathologically confirmed ovarian cancer who received neoadjuvant chemotherapy (NAC) at Yonsei Cancer Hospital. We divided the patients into groups based on the use of bevacizumab for NAC (CP group: carboplatin+paclitaxel vs. BCP group: bevacizumab+carboplatin+paclitaxel) and compared patient characteristics, responses to NAC, and surgical and survival outcomes between the two groups. Overall, 88 patients in the CP group and 16 patients in the BCP group received NAC. The primary endpoint was survival outcomes. Complete resection rate after interval debulking surgery (IDS), cancer antigen 125 (CA-125) normalization after NAC, and chemotherapy response score were secondary endpoints. RESULTS:After NAC treatment, all patients underwent IDS. There were no significant differences in adverse events during NAC or postoperative complications between the two groups (p=0.293 and p=0.485, respectively). There were also no significant differences in CA-125 normalization after NAC (42.0% vs. 43.8%, p=0.899) or complete resection rate after IDS (47.7% vs. 56.3%, p=0.530). However, although the BCP group did not show longer overall survival (OS) (log-rank p=0.854), they had significantly longer progression-free survival (PFS) than the CP group (log-rank p=0.048). CONCLUSION:Bevacizumab-containing NAC might be safe and provide longer PFS than chemotherapy alone in patients with advanced ovarian cancer. However, further study is necessary to investigate the impact of bevacizumab-containing NAC on OS.
journal_name
Yonsei Med Jjournal_title
Yonsei medical journalauthors
Park J,Eoh KJ,Nam EJ,Kim S,Kim SW,Kim YT,Lee JYdoi
10.3349/ymj.2020.61.4.284subject
Has Abstractpub_date
2020-04-01 00:00:00pages
284-290issue
4eissn
0513-5796issn
1976-2437pii
61.284journal_volume
61pub_type
杂志文章abstract：:Retinoic acid receptor-beta (RAR-beta) is induced by and mediates the growth-inhibitory and apoptotic effects of retinoic acid (RA), suggesting that loss of RAR-beta expression may be one of the critical events involved in the carcinogenesis/ progression of non-small cell lung cancer (NSCLC) and in the responsiveness ...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2004.45.3.435
更新日期：2004-06-30 00:00:00
abstract：PURPOSE:Distinguishing infiltrative renal cell carcinoma (RCC) from transitional cell carcinoma (TCC) is a challenging issue due to their radiologic similarities. We evaluated systemic inflammatory biomarkers as parameters for distinguishing tumor types. MATERIALS AND METHODS:A computerized search of medical records f...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2017.58.2.388
更新日期：2017-03-01 00:00:00
abstract：:When ventilatory support becomes necessary in patients with acute respiratory failure, there is an associated increase in complications. We reviewed the charts of acute respiratory failure patients with the ventilatory support retrospectively who were admitted to the General Intensive Care Unit, Yonsei University Coll...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.1994.35.2.142
更新日期：1994-06-01 00:00:00
abstract：PURPOSE:Elevated C-reactive protein (CRP) is associated with poor prognosis in several tumor types. The purpose of this study was to investigate serum CRP as a prognostic marker in small cell lung cancer (SCLC). MATERIALS AND METHODS:The pretreatment serum CRP level was measured in 157 newly diagnosed SCLC patients, a...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2012.53.1.111
更新日期：2012-01-01 00:00:00
abstract：:Although pectoralis major plays an important role as a prime or assistant mover for the varied range of shoulder movement, there was no significant functional loss in ordinary activities in case of congenital absence of this muscle, because of compensation of surrounding muscles. This report describes a 22-year-old so...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.1991.32.1.87
更新日期：1991-03-01 00:00:00
abstract：:We experienced a case of immunoglobulin E (IgE) mediated anaphylaxis to levodropropizine. The patient was an 18-year old Korean woman. After taking the common cold medication including acetaminophen, domperidone, and levodropropizine, skin rash, angioedema and anaphylaxis were developed immediately. As she was tolerab...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2013.54.1.262
更新日期：2013-01-01 00:00:00
abstract：PURPOSE:Cervical cancer is one of the most fatal diseases among women in under-developed countries. To improve cervical cancer treatment, discovery of new targets is needed. In this study, we investigated the expression of NUP210, miR-22, and Fas in cervical cancer tissues and their functions in cell cycle regulation. ...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2020.61.5.371
更新日期：2020-05-01 00:00:00
abstract：PURPOSE:In order to improve the likelihood of curative and safe gastric surgery, this study investigated the clinical features and surgical outcomes of gastric cancer with a synchronous cancer. PATIENTS AND METHODS:The clinicopathological data of 10,090 gastric cancer patients at Samsung Medical Center from September ...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2007.48.6.981
更新日期：2007-12-31 00:00:00
abstract：PURPOSE:Data comparing the clinical benefits of medical treatment with those of percutaneous coronary intervention (PCI) in an elderly population with angina pectoris are limited. Therefore, we evaluated the efficacy of elective PCI versus optimal medical treatment (OMT) in elderly patients (between 75 and 84 years old...
journal_title：Yonsei medical journal
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.3349/ymj.2016.57.2.382
更新日期：2016-03-01 00:00:00
abstract：PURPOSE:To evaluate the efficacy of minimal stimulation using discretely administered gonadotropin combined with clomiphene citrate (CC) or letrozole (LTZ) for intrauterine insemination (IUI) cycles. MATERIALS AND METHODS:Total 257 IUI cycles from 158 infertile couples were assessed. A CC dose of 100 mg/day (n=126 cyc...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2015.56.2.490
更新日期：2015-03-01 00:00:00
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journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2019.60.1.48
更新日期：2019-01-01 00:00:00
abstract：:In this study, the effects of chronically administered aluminum on iron metabolism-related parameters of liver and blood of mice were investigated. An additional purpose to determine how chronic aluminum administration together with vitamin E as an antioxidant to mice changed the parameters related to iron metabolism....
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2004.45.1.135
更新日期：2004-02-29 00:00:00
abstract：:To determine the carrier rate of beta-hemolytic streptococci (BHS), throat cultures were taken from healthy elementary school children in four separate areas of Korea from 1992 to 1995, including Inje, Nonsan, Seoul and Chinju. The strains of Streptococcus pyogenes had been serotyped with anti-T, -OF and -M sera. The ...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2000.41.1.56
更新日期：2000-02-01 00:00:00
abstract：:Telomeres undergo attrition with each cell division, and telomere length is associated with age-related diseases and mortality in the elderly. Estrogen can influence the attrition of telomeres by diverse mechanisms. This is a retrospective case control study that investigated the influence of long-term hormone therapy...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2005.46.4.471
更新日期：2005-08-31 00:00:00
abstract：:A coronary arteriovenous fistula consists of a communication between a coronary artery and a cardiac chamber, a great artery or the vena cava. It is the most common anomaly that can affect coronary perfusion. Bilateral involvement of coronary fistula, however, constitutes an uncommon subgroup of coronary arteriovenous...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.1997.38.3.190
更新日期：1997-06-01 00:00:00
abstract：:This corrects the article on p. 267 in vol. 60, PMID: 30799589. ...
journal_title：Yonsei medical journal
pub_type： 杂志文章,已发布勘误
doi：10.3349/ymj.2019.60.4.402
更新日期：2019-04-01 00:00:00
abstract：PURPOSE:We investigated the association between the tryptohan hydroxylase 1 (TPH1) gene and aggression in schizophrenia in a Korean population. MATERIALS AND METHODS:The sample included 61 aggressive patients as well as 104 non-aggressive patients from psychiatric hospitals and 335 healthy volunteers in Korea. Blood s...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2010.51.1.27
更新日期：2010-01-01 00:00:00
abstract：PURPOSE:Liver fibrosis is a major cause of morbidity and mortality and the outcome of various chronic liver diseases. Activation of hepatic stellate cells (HSCs) is the key event in liver fibrosis. Studies have confirmed that miR-140-3p plays a potential regulatory effect on HSC activation. However, whether miR-140-3p ...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2019.60.6.561
更新日期：2019-06-01 00:00:00
abstract：PURPOSE:The conventional trocar and cannula method in peritoneal dialysis (PD) catheter insertion has its limitation in clinical setting. The aim of this study was to compare a modified method for percutaneous PD catheter insertion with the conventional method, and demonstrate advantages of the modified method. MATERI...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2015.56.4.981
更新日期：2015-07-01 00:00:00
abstract：PURPOSE:Genes of the HoxD cluster play a major role in vertebrate limb development, and changes that modify the Hoxd12 locus affect other genes also, suggesting that HoxD function is coordinated by a control mechanism involving multiple genes during limb morphogenesis. In this study, mutant phenotypes were produced by ...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2008.49.6.965
更新日期：2008-12-31 00:00:00
abstract：:Left atrial appendage (LAA) occlusion can be employed as an alternative treatment to oral anticoagulation in patients with atrial fibrillation to prevent embolic events. Atrial septal defect (ASD) may be related with right heart dysfunction and allow paradoxical embolism to occur. However, occlusion of both LAA throug...
journal_title：Yonsei medical journal
pub_type：
doi：10.3349/ymj.2017.58.6.1237
更新日期：2017-11-01 00:00:00
abstract：:The healing pattern of medial and lateral cortical gap in open transverse or short oblique tibial fractures were retrospectively reviewed in 2 groups; In group A, 16 patients were treated by Judet external fixator in rigid mode. In group B, 6 patients were treated in biocompressive mode, which allowed predominantly lo...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.1995.36.2.130
更新日期：1995-05-01 00:00:00
abstract：:Many of the anesthetic considerations for fetal procedures and surgery are identical to those for nonobstetric surgery during pregnancy, including concern for maternal safety, avoidance of both teratogenic drugs and fetal asphyxia, and the prevention of preterm labor and delivery. Anesthesia is required for the mother...
journal_title：Yonsei medical journal
pub_type： 杂志文章,评审
doi：10.3349/ymj.2001.42.6.669
更新日期：2001-12-01 00:00:00
abstract：:The frontal sinus has been used for personal identification since the early part of the 20th century as a result of its tremendous interindividual variation. The frontal sinus is present in approximately 90% of adults. However, some populations have a higher proportion of people without a frontal sinus. This study inv...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2003.44.2.215
更新日期：2003-04-30 00:00:00
abstract：:A depressed level of natural killer (NK) activity is one of the various immunologic abnormalities in human immunodeficiency virus (HIV) infection. Interleukin-15 (IL-15), an immunotherapeutic candidate in HIV infection, increases NK activity and induces the excretion of CC-chemokines from divergent immune cells, but t...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2000.41.5.600
更新日期：2000-10-01 00:00:00
abstract：PURPOSE:The repopulating lymphocytes after allogeneic hematopoietic stem cell transplantation have an important role not only on the prevention of serious infections in the early transplantation period, but also on the killing of residual leukemic cells by graft-versus-leukemia effect. The aim of this study was to anal...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2013.54.1.62
更新日期：2013-01-01 00:00:00
abstract：PURPOSE:The aim of this study was to compare survival of patients with uterine sarcomas using the 1988 and 2008 International Federation of Gynecologists and Obstetricians (FIGO) staging systems to determine if revised 2008 staging accurately predicts patient survival. MATERIALS AND METHODS:A total of 83 patients with...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2014.55.3.563
更新日期：2014-05-01 00:00:00
abstract：:Strength training is one of the most common exercises practiced in the field of physical therapy or sports training. However, limited methodology is available to evaluate its effect on the target muscle. This study aimed to test the hypothesis that surface electromyographic (EMG) data from both isometric and isotonic ...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2006.47.1.93
更新日期：2006-02-28 00:00:00
abstract：:When cells are exposed to a low dose of a mutagenic or clastogenic agent, they often become less sensitive to the effects of a higher dose administered subsequently. Such adaptive responses were first described in Escherichia coli. Studies on mammalian cells have been limited to human lymphocytes exposed to low doses ...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.1994.35.1.77
更新日期：1994-03-01 00:00:00
abstract：:To evaluate the longterm effects of a IUD on the human endometrium and find the possible contraceptive mechanism of the IUD, histologic, histochemical, and ultrastructural studies of human endometrial biopsies from 44 normal contorls and 178 IUD wearers were made. Histologic findings included interstitial hemorrhage,...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.1983.24.2.141
更新日期：1983-01-01 00:00:00
