Whole blood interferon-γ release assay is insufficient for the diagnosis of sputum smear negative pulmonary tuberculosis.

Abstract:

PURPOSE:We investigated the value of an interferon-γ release assay (IGRA) for the diagnosis of active pulmonary tuberculosis (PTB) among sputum smear negative PTB suspects in an environment with intermediate burden of PTB and high Bacillus Calmette-Guerin (BCG) vaccination rate. MATERIALS AND METHODS:We retrospectively reviewed IGRA, medical records, chest PA and CT scan of PTB suspects seen at Gangnam Severance Hospital, Seoul, Korea from Oct. 2007 to Apr. 2013. "Active PTB" was diagnosed when 1) M. tuberculosis culture positive, 2) confirmation by pathologic examination; or 3) clinical findings compatible with TB. RESULTS:Of 224 sputum smear negative PTB suspects, 94 were confirmed as having active PTB. There were no statistically significant differences in the diagnostic yield of IGRA between immunocompromised and immunocompetent sputum smear negative PTB suspects. IGRA did show superior sensitivity [81.9%, 95% confidence interval (CI); 74.13-89.70%] in the diagnosis of sputum smear negative PTB when compared with chest high-resolution computed tomography (HRCT), tuberculin skin test (TST), and chest X-ray (p<0.001). Also, IGRA showed highest negative predictive value (82.7%, 95% CI; 75.16-90.15%) when compared with HRCT, TST and chest X-ray (p=0.023). However, combining the results of IGRA with those of HRCT, TST, or both did not increase any diagnostic parameters. CONCLUSION:Failure to increase diagnostic yields by combination with other diagnostic modalities suggests that additional enforcement with IGRA may be insufficient to exclude other diagnoses in sputum smear negative PTB suspects and to screen active PTB in an environment with intermediate TB prevalence and a high BCG vaccination rate.

journal_name

Yonsei Med J

journal_title

Yonsei medical journal

authors

Park H,Shin JA,Kim HJ,Ahn CM,Chang YS

doi

10.3349/ymj.2014.55.3.725

subject

Has Abstract

pub_date

2014-05-01 00:00:00

pages

725-31

issue

3

eissn

0513-5796

issn

1976-2437

pii

201405725

journal_volume

55

pub_type

杂志文章
  • Hemodynamic, Autonomic, and Vascular Function Changes after Sleep Deprivation for 24, 28, and 32 Hours in Healthy Men.

    abstract::This study aimed to analyze the impact of sleep deprivation (SD) on cardiac, hemodynamic, and endothelial parameters and to determine whether these are sustained with increased periods of SD. The study included 60 healthy men (mean: age 31.2±6.3 years; body mass index 24.6±2.6 kg/m²). Hemodynamic parameters, parameter...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2018.59.9.1138

    authors: Słomko J,Zawadka-Kunikowska M,Kozakiewicz M,Klawe JJ,Tafil-Klawe M,Newton JL,Zalewski P

    更新日期:2018-11-01 00:00:00

  • Morphological evidence of pulmonary vascular leakage through gaps observed with casting methods and S.E.M.

    abstract::We have used selective casting methods to separate pulmonary elastin from vascular elastin in the lungs of rabbits, dogs and pigs. The lungs are digested with 0.1 N NaOH at 75 degrees C for 24 approximately 48 hours with frequent turning as the lungs are filled with air to about 80% of the vital capacity prior to the ...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.1992.33.4.303

    authors: Song SH,Kratky RG,Roach MR

    更新日期:1992-12-01 00:00:00

  • Tissue engineering in the twenty-first century.

    abstract::In the 20th century, free tissue transfers have been successfully introduced using microvascular anastomosis techniques. Transplants not only include whole organs such as the kidney, liver and lung, but also bone, muscle and skin. However, there are a limited number of organs available for transplantation. This leads ...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章,评审

    doi:10.3349/ymj.2000.41.6.685

    authors: Terada S,Sato M,Sevy A,Vacanti JP

    更新日期:2000-12-01 00:00:00

  • Development of a clinical protocol for home hospice care for Koreans.

    abstract::As the Korean government's recognition of the importance of hospice service grows, the government has initiated a variety of hospice services in Korea. Each hospice organization has shown a significant difference in its health care delivery methods, constitution and care content. Developing a clinical protocol is esse...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2005.46.1.8

    authors: Lee WH,Lee CG

    更新日期:2005-02-28 00:00:00

  • Anti-Toxoplasma gondii antibodies in haemodialysis patients with chronic renal failure.

    abstract:UNLABELLED:This study aimed to determine the prevalence of anti- Toxoplasma gondii antibodies in haemodialysis patients with chronic renal failure (CRF). METHODS:One hundred and seventy three haemodialysis patients, and 40 healthy controls, were studied for the prevalence of anti-Toxoplasma gondii antibodies by a micr...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2003.44.2.288

    authors: Yazar S,Demirtaş F,Yalçin S,Yaman O,Tokgöz B,Utaş C,Sahin I

    更新日期:2003-04-30 00:00:00

  • Lateralization of cognitive functions in aphasia after right brain damage.

    abstract:PURPOSE:The lateralization of cognitive functions in crossed aphasia in dextrals (CAD) has been explored and compared mainly with cases of aphasia with left hemisphere damage. However, comparing the neuropsychological aspects of CAD and aphasia after right brain damage in left-handers (ARL) could potentially provide mo...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2012.53.3.486

    authors: Ha JW,Pyun SB,Hwang YM,Sim H

    更新日期:2012-05-01 00:00:00

  • Multiple small intestinal stromal tumors associated with neurofibromatosis-1.

    abstract::Gastrointestinal stromal tumors (GISTs) are rarely noted in association with neurofibromatosis-1 (NF-1, von Recklinghausen disease) as an individual gastrointestinal manifestation. We report here a case of multiple GISTs with an abundant skeinoid fiber in the jejunum of a 43-year-old woman diagnosed as NF-1. Histologi...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2004.45.3.564

    authors: Joo M,Lee HK,Kim H,Kim MK,Chi JG

    更新日期:2004-06-30 00:00:00

  • Penoscrotal reconstruction using groin and bilateral superomedial thigh flaps: a case of penile vaselinoma causing Fournier's gangrene.

    abstract::Penile augmentation by the injection of mineral oil provokes many serious, undesirable effects. Although there are reports of complications such as deformity, ulceration, necrosis, and erectile dysfunction, Fournier's gangrene resulting from the injection of petroleum jelly into the penis has not been reported. Here, ...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2007.48.4.723

    authors: Lee SW,Bang CY,Kim JH

    更新日期:2007-08-31 00:00:00

  • Progressive change in joint degeneration in patients with knee or hip osteoarthritis treated with fentanyl in a randomized trial.

    abstract:PURPOSE:Opioids improve pain from knee and hip osteoarthritis (OA) and decrease the functional impairment of patients. However, there is a possibility that opioids induce analgesia and suppress the physiological pain of OA in patients, thereby inducing the progression of OA changes in these patients. The purpose of the...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章,随机对照试验

    doi:10.3349/ymj.2014.55.5.1379

    authors: Fujii T,Takana K,Orita S,Inoue G,Ochiai N,Kuniyoshi K,Aoki Y,Ishikawa T,Miyagi M,Kamoda H,Suzuki M,Sakuma Y,Kubota G,Oikawa Y,Inage K,Sainoh T,Sato J,Yamauchi K,Toyone T,Nakamura J,Kishida S,Takahashi K,Ohtori

    更新日期:2014-09-01 00:00:00

  • Noninfectious Complications of Peritoneal Dialysis in Korean Children: A 26-Year Single-Center Study.

    abstract:PURPOSE:The aim of this study was to investigate noninfectious complications of peritoneal dialysis (PD), including mechanical and metabolic complications, at a single center in Korea. MATERIALS AND METHODS:We analyzed data from 60 PD patients aged ≤18 years (40 boys and 20 girls) during the period between 1986 and 20...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2015.56.5.1359

    authors: Kim JE,Park SJ,Oh JY,Kim JH,Lee JS,Kim PK,Shin JI

    更新日期:2015-09-01 00:00:00

  • Granular Cell Tumors on Unusual Anatomic Locations.

    abstract::Granular cell tumors (GCTs) are soft tissue tumors, which are thought to be derived from Schwann cells. Although most GCTs are reported to arise in tongue and oral cavity (30-50%), they can appear on any anatomic sites, even visceral organs. Herein, we report 5 cases of GCTs on unusual anatomic locations, such as palm...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2015.56.6.1731

    authors: Kim HJ,Lee MG

    更新日期:2015-11-01 00:00:00

  • Characteristics of corticospinal tract area according to pontine level.

    abstract::Diffusion tensor imaging (DTI) allows to isolate the corticospinal tract (CST) area from adjacent structures. Using DTI, we investigated the characteristics of the CST areas according to the pontine level in the normal human brain. We recruited 33 healthy subjects and DTIs were acquired using a sensitivity-encoding he...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2013.54.3.785

    authors: Seo JP,Jang SH

    更新日期:2013-05-01 00:00:00

  • miR-140-3p Knockdown Suppresses Cell Proliferation and Fibrogenesis in Hepatic Stellate Cells via PTEN-Mediated AKT/mTOR Signaling.

    abstract:PURPOSE:Liver fibrosis is a major cause of morbidity and mortality and the outcome of various chronic liver diseases. Activation of hepatic stellate cells (HSCs) is the key event in liver fibrosis. Studies have confirmed that miR-140-3p plays a potential regulatory effect on HSC activation. However, whether miR-140-3p ...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2019.60.6.561

    authors: Wu SM,Li TH,Yun H,Ai HW,Zhang KH

    更新日期:2019-06-01 00:00:00

  • Donor bone marrow infusion in deceased and living donor renal transplantation.

    abstract::The infusion and persistence in a transplant recipient of donor-derived bone marrow cells (DBMC) of multi-lineage can lead to a state of permanent chimerism. In solid vascular organ transplantation, the donor bone marrow lineage cells can even be derived from the transplant organ, and these cells can be detected in ve...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章,评审

    doi:10.3349/ymj.2004.45.6.998

    authors: Ciancio G,Burke GW,Moon J,Garcia-Morales R,Rosen A,Esquenazi V,Mathew J,Jin Y,Miller J

    更新日期:2004-12-31 00:00:00

  • Anesthesia for fetal procedures and surgery.

    abstract::Many of the anesthetic considerations for fetal procedures and surgery are identical to those for nonobstetric surgery during pregnancy, including concern for maternal safety, avoidance of both teratogenic drugs and fetal asphyxia, and the prevention of preterm labor and delivery. Anesthesia is required for the mother...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章,评审

    doi:10.3349/ymj.2001.42.6.669

    authors: Rosen MA

    更新日期:2001-12-01 00:00:00

  • Change in Renal Function among HIV-Infected Koreans Receiving Tenofovir Disoproxil Fumarate-Backbone Antiretroviral Therapy: A 3-Year Follow-Up Study.

    abstract:PURPOSE:Tenofovir disoproxil fumarate (TDF) is commonly prescribed as a fixed-dose, co-formulated antiretroviral drug for HIV-1 infection. The major concern of long-term TDF use is renal dysfunction. However, little is known about the long-term patterns of changes in renal function in HIV-infected Koreans receiving TDF...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2017.58.4.770

    authors: Lee KH,Lee JU,Ku NS,Jeong SJ,Han SH,Choi JY,Song YG,Kim JM

    更新日期:2017-07-01 00:00:00

  • Selective neck dissection for clinically node-positive oral cavity squamous cell carcinoma.

    abstract:PURPOSE:The treatment of a clinically node-positive (cN+) neck is important in the management of oral cavity squamous cell carcinoma (OSCC). However, the extent of neck dissection (ND) remains controversial. The purpose of our study was to evaluate whether level IV or V can be excluded in therapeutic ND for cN+ OSCC pa...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2013.54.1.139

    authors: Shin YS,Koh YW,Kim SH,Choi EC

    更新日期:2013-01-01 00:00:00

  • Associations between Single Nucleotide Polymorphisms of High Mobility Group Box 1 Protein and Clinical Outcomes in Korean Sepsis Patients.

    abstract:PURPOSE:High mobility group box 1 (HMGB1) plays a central role in the pathogenesis of sepsis and multiple organ dysfunction syndromes. We investigated the associations of a single nucleotide polymorphism (SNP; rs1045411) in HMGB1 with various clinical parameters, severity, and prognosis in patients with sepsis, severe ...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2016.57.1.111

    authors: Lee K,Chang Y,Song K,Park YY,Huh JW,Hong SB,Lim CM,Koh Y

    更新日期:2016-01-01 00:00:00

  • Giant Meckel's diverticulum associated with a congenital diaphragmatic hernia.

    abstract::Giant Meckel's diverticulum is a very rare lesion and its association with a congenital diaphragmatic hernia has not been reported previously. We report a case of newborn with a giant Meckel's diverticulum and congenital diaphragmatic hernia. A large round atypical air-filled bowel segment was found by chest radiograp...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2004.45.1.177

    authors: Kang IS,Ahn SM,Han A,Oh JT,Han SJ,Choi SH,Hwang EH

    更新日期:2004-02-29 00:00:00

  • Use of vaccine in the era of antimicrobial resistance: need of effective pneumococcal vaccines.

    abstract::Streptococcus pneumoniae is an important pathogen causing invasive infections particularly in children. Penicillin-nonsusceptible pneumococci are very prevalent in Korea and a difficult problem in antimicrobial treatment. Immunization with effective vaccines including viral and bacterial vaccines has proven to be the ...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章,评审

    doi:10.3349/ymj.1998.39.6.611

    authors: Sohn YM

    更新日期:1998-12-01 00:00:00

  • Effects of chronic aluminum administration on blood and liver iron-related parameters in mice.

    abstract::In this study, the effects of chronically administered aluminum on iron metabolism-related parameters of liver and blood of mice were investigated. An additional purpose to determine how chronic aluminum administration together with vitamin E as an antioxidant to mice changed the parameters related to iron metabolism....

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2004.45.1.135

    authors: Turgut G,Kaptanoğlu B,Turgut S,Enli Y,Genç O

    更新日期:2004-02-29 00:00:00

  • Correlation between EGFR and c-erbB-2 oncoprotein status and response to neoadjuvant chemotherapy in cervical carcinoma.

    abstract::Neoadjuvant chemotherapy prior to definitive radical surgery or radiotherapy may be effective in reducing tumor volume or clinical stage and may even enhance pelvic control and survival. However, there are significant limitations to the use of neoadjuvant therapy in the non-responder group. They include delayed total ...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.1999.40.3.207

    authors: Kim JW,Kim YT,Kim DK

    更新日期:1999-06-01 00:00:00

  • Specially programmed respiratory muscle training for singers by using respiratory muscle training device (Ultrabreathe).

    abstract::Respiratory muscle training is one of the major methods for enhancing the vocal function. Singers who must use their voice most frequently are well aware of the importance of respiration. However, most of them do not know precisely how to exercise their abdominal respiration. Using a respiratory training device, singe...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2004.45.5.810

    authors: Nam DH,Lim JY,Ahn CM,Choi HS

    更新日期:2004-10-31 00:00:00

  • Operative laparoscopy in treating benign ovarian cysts.

    abstract::This study was undertaken to evaluate the clinical usefulness of operative laparoscopy in treatment of benign ovarian cysts. A retrospective study was carried on 468 operative laparoscopy cases performed from September 1995 to September 1998 at Yonsei University College of Medicine, Department of Obstetrics and Gyneco...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.1999.40.6.608

    authors: Park KH,Chung JE,Kim JY,Lee BS

    更新日期:1999-12-01 00:00:00

  • Endoscopic laser surgery for subglottic stenosis in Wegener's granulomatosis.

    abstract:PURPOSE:Wegener's granulomatosis (WG) is a rare multisystem inflammatory disease, which infrequently involves the subglottic area and trachea. Treatment usually involves the use of immunosuppressive agents with corticosteroids. Some patients, however, continue to have symptoms of airway obstruction after clinical remis...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2007.48.5.748

    authors: Shvero J,Shitrit D,Koren R,Shalomi D,Kramer MR

    更新日期:2007-10-31 00:00:00

  • Extracellular Vesicles Derived from Hypoxic Human Mesenchymal Stem Cells Attenuate GSK3β Expression via miRNA-26a in an Ischemia-Reperfusion Injury Model.

    abstract:PURPOSE:Bioactive molecules critical to intracellular signaling are contained in extracellular vesicles (EVs) and have cardioprotective effects in ischemia/reperfusion (IR) injured hearts. This study investigated the mechanism of the cardioprotective effects of EVs derived from hypoxia-preconditioned human mesenchymal ...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2018.59.6.736

    authors: Park H,Park H,Mun D,Kang J,Kim H,Kim M,Cui S,Lee SH,Joung B

    更新日期:2018-08-01 00:00:00

  • Helicobacter pylori: bacterial strategy for incipient stage and persistent colonization in human gastric niches.

    abstract::Helicobacter pylori (H. pylori) undergoes decades long colonization of the gastric mucosa of half the population in the world to produce acute and chronic gastritis at the beginning of infection, progressing to more severe disorders, including peptic ulcer disease and gastric cancer. Prolonged carriage of H. pylori is...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2014.55.6.1453

    authors: Rhee KH,Park JS,Cho MJ

    更新日期:2014-11-01 00:00:00

  • Antimicrobial susceptibility of Campylobacter fetus subsp. fetus isolated from blood and synovial fluid.

    abstract::Campylobacter fetus subsp. fetus is a rare human pathogen, but can cause serious extraintestinal infections. Effective antimicrobial agent is required for the therapy, but we have very limited knowledge on the susceptibility of the organism. In this study, the susceptibility of 25 isolates of the organism to 14 antimi...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.1994.35.3.314

    authors: Kwon SY,Cho DH,Lee SY,Lee K,Chong Y

    更新日期:1994-09-01 00:00:00

  • A case of suspected isotretinoin-induced malformation in a baby of a mother who became pregnant one month after discontinuation of the drug.

    abstract::Isotretinoin is a known human teratogen that can cause multiple malformations. At present, women who conceive one cycle after discontinuing isotretinoin are told that their teratogenic risk is not higher than baseline. We present a case of both-ear malformation in a newborn whose mother had taken isotretinoin for 2 ye...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2009.50.3.445

    authors: Lee SM,Kim HM,Lee JS,Yoon CS,Park MS,Park KI,Namgung R,Lee C

    更新日期:2009-06-30 00:00:00

  • Prevalence and clinical factors of anxiety and depression in neurally mediated and unexplained syncope.

    abstract:PURPOSE:Several studies have demonstrated that psychiatric disorders such as anxiety, depression and panic attack are associated with syncope, especially vasovagal and unexplained syncope (US). The aim of this study was to compare the prevalence of anxiety and depression between patients with neurally mediated syncope ...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2013.54.3.583

    authors: Lee SH,Park SJ,Byeon K,On YK,Yim HR,Kim JS

    更新日期:2013-05-01 00:00:00