Helicobacter pylori: bacterial strategy for incipient stage and persistent colonization in human gastric niches.

Abstract:

:Helicobacter pylori (H. pylori) undergoes decades long colonization of the gastric mucosa of half the population in the world to produce acute and chronic gastritis at the beginning of infection, progressing to more severe disorders, including peptic ulcer disease and gastric cancer. Prolonged carriage of H. pylori is the most crucial factor for the pathogenesis of gastric maladies. Bacterial persistence in the gastric mucosa depends on bacterial factors as well as host factors. Herein, the host and bacterial components responsible for the incipient stages of H. pylori infection are reviewed and discussed. Bacterial adhesion and adaptation is presented to explain the persistence of H. pylori colonization in the gastric mucosa, in which bacterial evasion of host defense systems and genomic diversity are included.

journal_name

Yonsei Med J

journal_title

Yonsei medical journal

authors

Rhee KH,Park JS,Cho MJ

doi

10.3349/ymj.2014.55.6.1453

subject

Has Abstract

pub_date

2014-11-01 00:00:00

pages

1453-66

issue

6

eissn

0513-5796

issn

1976-2437

pii

2014111453

journal_volume

55

pub_type

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