Human papillomavirus type 16 E5 protein as a therapeutic target.

Abstract:

:Cervical cancer is a progressive disease with an onset of one to two decades on average. During the productive replication stage, the Human papillomavirus (HPV) genome is maintained episomally in the infected cervical epithelium and early gene products, including E5, are expressed. Therefore, E5 has a potential to contribute to the HPV-associated carcinogenic process. In invasive malignancies, the HPV genomes are commonly integrated into the host genome, and E6 and E7 genes remain intact. However, the E5 is lost or, if present, under-expressed as compared with the E6 and E7 proteins. This suggests that E5 may play a critical role in the genesis of cervical cancer but less of a role in its persistence or progression. In the initiation of neoplasia and the premalignant stage, there are fewer malignant cells than in the invasive malignancies. Moreover, cells in the invasive malignant stage are found to have a very low level of MHC class I and II, which could hamper the presentation of the antigen and lead to a decreased immune response. Since the E5 protein is likely to play a role during the early tumorigenesis stage, a therapeutic vaccine to target and eliminate the E5-expressing cells may be a good strategy to prevent premalignant lesions from progressing toward invasive cervical cancers. This paper provides an overview of HPV-induced cervical carcinogenesis and strategies for designing prophylactic and therapeutic vaccines to prevent and cure the cervical cancer. In particular, focus will be on the rationale of targeting the E5 protein to develop therapeutic vaccines.

journal_name

Yonsei Med J

journal_title

Yonsei medical journal

authors

Kim SW,Yang JS

doi

10.3349/ymj.2006.47.1.1

keywords:

subject

Has Abstract

pub_date

2006-02-28 00:00:00

pages

1-14

issue

1

eissn

0513-5796

issn

1976-2437

pii

200602001

journal_volume

47

pub_type

杂志文章,收录出版,评审
  • Restoration of P-glycoprotein function is involved in the increase of natural killer activity with exogenous interleukin-15 in human immunodeficiency virus-infected individuals.

    abstract::A depressed level of natural killer (NK) activity is one of the various immunologic abnormalities in human immunodeficiency virus (HIV) infection. Interleukin-15 (IL-15), an immunotherapeutic candidate in HIV infection, increases NK activity and induces the excretion of CC-chemokines from divergent immune cells, but t...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2000.41.5.600

    authors: Chang KH,Kim JM,Yoo NC,Kim WH,Park JH,Choi IH,Kim HS,Lee KW,Song YG,Hong SK,Kim HY

    更新日期:2000-10-01 00:00:00

  • The effect of sodium cromoglycate on the induction of experimental IgA nephropathy.

    abstract::Mesangial IgA nephropathy was experimentally induced in ddY mice by oral and parenteral administration of the poliomyelitis vaccine (POLIO), and we then tried to investigate if IgA deposition could be prevented by the concurrent use of sodium cromoglycate (SCG), which is known to inhibit the local mucosal immune react...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.1990.31.1.33

    authors: Jin SY,Choi IJ

    更新日期:1990-03-01 00:00:00

  • Update on Early Nutrition and Food Allergy in Children.

    abstract::With growing evidence of an increase in the prevalence, food allergy has been emerged as a new public health problem. As treatment and management of food allergy remain challenging, more attention has been paid to the importance of prevention of food allergy. Although the exact mechanism of recent epidemic is not full...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章,评审

    doi:10.3349/ymj.2016.57.3.542

    authors: Lee SE,Kim H

    更新日期:2016-05-01 00:00:00

  • Imaging findings of giant liposarcoma of the esophagus.

    abstract::A giant esophageal liposarcoma showing rapid growth over 7 months is presented in 56-year-old man. It originated from the pharyngo-esophageal junction with a short stalk, and extended downward to the distal esophagus. A barium swallow study showed a large, sausage-like intraluminal mass in the dilated esophagus. CT an...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2003.44.4.715

    authors: Chung JJ,Kim MJ,Kim JH,Lee JT,Yoo HS,Kim KW

    更新日期:2003-08-30 00:00:00

  • Hypertension Risk with Abacavir Use among HIV-Infected Individuals: A Nationwide Cohort Study.

    abstract:PURPOSE:A high risk of cardiovascular disease (CVD) is reported for HIV-infected individuals. While a link between abacavir and CVD risk is suggested, an association between abacavir and hypertension remains unclear. This study evaluated hypertension risk with abacavir use in comparison to non-abacavir antiretroviral t...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2018.59.10.1245

    authors: Kim J,Bang JH,Shin JY,Yang BR,Lee J,Park BJ

    更新日期:2018-12-01 00:00:00

  • Diagnostic value of insulin-like growth factor-I in short stature.

    abstract::For the present, to determine growth hormone(GH) deficiency in patients with short stature, many provocative tests using various pharmacological agents such as glucagon, insulin, clonidine, arginine, growth hormone releasing factor, etc. should be done. These are not only complicated but are also misleading in some pa...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.1989.30.4.367

    authors: Park MS,Kim DH

    更新日期:1989-12-01 00:00:00

  • Optimal anticoagulation during off pump coronary artery bypass in patients recently exposed to clopidogrel.

    abstract:PURPOSE:The aim of this study was to find an optimal range of activated clotting time (ACT) during off-pump coronary artery bypass surgery (OPCAB) yielding ischemic protection without the risk of hemorrhagic complications in patients with recent exposure to dual antiplatelet therapy. MATERIALS AND METHODS:Three hundre...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2013.54.5.1119

    authors: Song Y,Song JW,Shim JK,Kwak YL

    更新日期:2013-09-01 00:00:00

  • Microsatellite marker in gamma - aminobutyric acid - a receptor beta 3 subunit gene and autism spectrum disorders in Korean trios.

    abstract::This study aimed to identify the association between gamma-aminobutyric acid-A (GABA-A) receptor subunit beta3 (GABRB3) gene and autism spectrum disorders (ASD) in Korea. Fifty-eight children with ASD [47 boys (81.0%), 5.5 +/- 4.1 years old], 46 family trios, and 86 healthy control subjects [71 males (82.6%), 33.6 +/-...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2009.50.2.304

    authors: Yoo HK,Chung S,Hong JP,Kim BN,Cho SC

    更新日期:2009-04-30 00:00:00

  • Neck circumference and lowest oxygen saturation are independently associated with high coexistence of hypertension in obstructive sleep apnea.

    abstract:PURPOSE:Obstructive sleep apnea (OSA) is considered an independent risk factor for hypertension. However, it is still not clear which clinical factors are related with the presence of hypertension in OSA patients. We aimed to find different physical features and compare the sleep study results which are associated with...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2014.55.5.1310

    authors: Min HJ,Park AY,Kim DH,Lee JG,Park S,Cho HJ

    更新日期:2014-09-01 00:00:00

  • Identification of differentially expressed genes in papillary thyroid cancers.

    abstract:PURPOSE:Techniques designed to identify differentially expressed genes (DEGs) in tumors have become important in modern pathology. Genefishing technique using the annealing control primer (ACP) system has recently been developed to screen for DEG transcripts. We tried to identify DEGs involved in papillary thyroid canc...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2009.50.1.60

    authors: Lee KY,Huang SM,Li S,Kim JM

    更新日期:2009-02-28 00:00:00

  • FIGO staging for uterine sarcomas: can the revised 2008 staging system predict survival outcome better?

    abstract:PURPOSE:The aim of this study was to compare survival of patients with uterine sarcomas using the 1988 and 2008 International Federation of Gynecologists and Obstetricians (FIGO) staging systems to determine if revised 2008 staging accurately predicts patient survival. MATERIALS AND METHODS:A total of 83 patients with...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2014.55.3.563

    authors: Yim GW,Nam EJ,Kim SW,Kim YT

    更新日期:2014-05-01 00:00:00

  • Diagnosis of the double aortic arch and its differentiation from the conotruncal malformations.

    abstract:PURPOSE:The clinical and radiological characteristics of the double aortic arch (DAA) and its differentiation from conotruncal malformations (CTM) were reported in order to familiarize pediatric practitioners with these congenital heart diseases. MATERIALS AND METHODS:From July 1994 to December 2006, a total of 6 pati...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2007.48.5.818

    authors: Lee ML

    更新日期:2007-10-31 00:00:00

  • mTOR Signaling Combined with Cancer Stem Cell Markers as a Survival Predictor in Stage II Colorectal Cancer.

    abstract:PURPOSE:Wnt and mammalian target of rapamycin (mTOR) are major molecular signaling pathways associated with the development and progression of tumor, as well as the maintenance and proliferation of cancer stem cells (CSCs), in colorectal cancer (CRC). Identifying patients at risk of poor prognosis is important to deter...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2020.61.7.572

    authors: Chang JY,Kim JH,Kang J,Park Y,Park SJ,Cheon JH,Kim WH,Kim H,Park JJ,Kim TI

    更新日期:2020-07-01 00:00:00

  • Extradural approach to the lateral sellar compartment.

    abstract::This paper describes an extradural approach to the lateral sellar compartment (LSC, cavernous sinus), which represents a refinement of the original work performed on this topic by Parkinson, Dolenc, and Hakuba, and other enthusiastic neurosurgeons. This detailed description of the extradural approach is based on the d...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2001.42.1.120

    authors: Lee KS

    更新日期:2001-02-01 00:00:00

  • Interaction between warfarin and the herbal product Shengmai-yin: a case report of intracerebral hematoma.

    abstract::A 71-year-old man was stable on warfarin (2.25 mg daily) therapy with an international normalized ratio (INR) of 1.8-2.2 after a heart valve replacement surgery. Recently, he consumed the liquid-like herbal product called shengmai-yin (10 mL daily) against medical advice. Seven days after the daily consumption of shen...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2010.51.5.793

    authors: Su Q,Li Y

    更新日期:2010-09-01 00:00:00

  • Influence of primary tumor site on host anti-tumor immunity.

    abstract::Stage IV-S neuroblastoma, characterized by a primary tumor plus disseminated tumors in liver, skin and bone marrow, has a favorable clinical prognosis when compared to metastatic Stage IV neuroblastoma. This favorable outcome also characterized mice receiving tumor transplants to these "IV-S" sites. We report the test...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.1992.33.3.258

    authors: Choi SH,Lim TS,Hwang EH

    更新日期:1992-09-01 00:00:00

  • Cytological results of ultrasound-guided fine-needle aspiration cytology for thyroid nodules: emphasis on correlation with sonographic findings.

    abstract:PURPOSE:To compare the cytological results of ultrasound-guided fine-needle aspiration (US-FNA) cytology of thyroid nodules to sonographic findings and determine whether US findings are helpful in the interpretation of cytological results. MATERIALS AND METHODS:Among the thyroid nodules that underwent US-FNA cytology,...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2011.52.5.838

    authors: Lee MJ,Hong SW,Chung WY,Kwak JY,Kim MJ,Kim EK

    更新日期:2011-09-01 00:00:00

  • The role of H1- and H2-receptors in the effect of compound 48/80 in the asphyxiation and body temperature of mice.

    abstract::Contribution of histamine H1- and H2-receptors to the effect of compound 48/80, a potent histamine releaser, upon asphyxiation and body temperature in mice was investigated in the present experiments. Compound 48/80 showed an apparent protective potency against hypoxia and significantly prolonged the latencies for con...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.1996.37.2.97

    authors: Ulugöl A,Karadag H,Dökmeci D,Dökmeci I

    更新日期:1996-04-01 00:00:00

  • Use of grafts in pelvic reconstructive surgery.

    abstract::There has been growing interest in the use of grafts in pelvic reconstructive surgery. This article will address available graft materials and assess their clinical efficacy and safety. We conducted a Pubmed MEDLINE literature search for full-length English text studies with follow-up periods of at least one year. The...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2007.48.2.147

    authors: Jeon MJ,Bai SW

    更新日期:2007-04-30 00:00:00

  • Effect of Patient-Prosthesis Mismatch in Aortic Position on Late-Onset Tricuspid Regurgitation and Clinical Outcomes after Double Valve Replacement.

    abstract:PURPOSE:Significant late-onset tricuspid regurgitation (TR) is unfortunately common after double valve replacement (DVR); however, its underlying factors remain undefined. We evaluated the effect of aortic patient-prosthesis mismatch (PPM) on late-onset TR and clinical outcomes after DVR. MATERIALS AND METHODS:Of the ...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2017.58.5.968

    authors: Lee SH,Youn YN,Chang BC,Joo HC,Lee S,Yoo KJ

    更新日期:2017-09-01 00:00:00

  • Correlation between EGFR and c-erbB-2 oncoprotein status and response to neoadjuvant chemotherapy in cervical carcinoma.

    abstract::Neoadjuvant chemotherapy prior to definitive radical surgery or radiotherapy may be effective in reducing tumor volume or clinical stage and may even enhance pelvic control and survival. However, there are significant limitations to the use of neoadjuvant therapy in the non-responder group. They include delayed total ...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.1999.40.3.207

    authors: Kim JW,Kim YT,Kim DK

    更新日期:1999-06-01 00:00:00

  • Low-dose methotrexate therapy for intravenous immunoglobulin-resistant Kawasaki disease.

    abstract:PURPOSE:The aim of this study was to evaluate the efficacy of low-dose oral methotrexate (MTX) as a treatment for patients with Kawasaki disease (KD) which was resistant to intravenous immunoglobulin (IVIG). PATIENTS AND METHODS:The patients who had persistent or recrudescent fever after treatment with IVIG were subse...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2008.49.5.714

    authors: Lee TJ,Kim KH,Chun JK,Kim DS

    更新日期:2008-10-31 00:00:00

  • High-Sensitivity C-Reactive Protein Can Reflect Small Airway Obstruction in Childhood Asthma.

    abstract:PURPOSE:High-sensitivity assays enabled the identification of C-reactive protein (hs-CRP) at levels that were previously undetectable. We aimed to determine if hs-CRP could reflect airway inflammation in children, by comparing hs-CRP with spirometry and impulse oscillometry (IOS) parameters and symptomatic severities. ...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2016.57.3.690

    authors: Ko AR,Kim YH,Sol IS,Kim MJ,Yoon SH,Kim KW,Kim KE

    更新日期:2016-05-01 00:00:00

  • A case of life-threatening acute kidney injury with toxic encephalopathy caused by Dioscorea quinqueloba.

    abstract::Some herbal medications induce acute kidney injury. The acute kidney injuries caused by herbal medications are mild and commonly treated by palliative care. A 51-years-old man who drank the juice squeezed from the raw tubers of Dioscorea quinqueloba (D. quinqueloba) was admitted with nausea, vomiting and chilling. He ...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2015.56.1.304

    authors: Kang KS,Heo ST

    更新日期:2015-01-01 00:00:00

  • Acute lymphoblastic leukemia associated with brucellosis in two patients with fever and pancytopenia.

    abstract::Brucellosis is a disease involving the lymphoproliferative system, which may lead to changes in the hematological parameters; however, pancytopenia is a rare finding. However, malignant diseases in association with brucellosis are rarely the cause of pancytopenia. Herein, two cases with fever and pancytopenia, diagnos...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2006.47.5.741

    authors: Eser B,Altuntas F,Soyuer I,Er O,Canoz O,Coskun HS,Cetin M,Unal A

    更新日期:2006-10-31 00:00:00

  • Diagnosis of overt disseminated intravascular coagulation: a comparative study using criteria from the International Society versus the Korean Society on Thrombosis and Hemostasis.

    abstract:PURPOSE:Since 1993, Koreans have used diagnostic criteria set by the Korean Society on Thrombosis and Hemostasis (KSTH) in the diagnosis of overt disseminated intravascular coagulation (DIC). In 2001, the Scientific and Standardization Committee (SCC) of the International Society on Thrombosis and Hemostasis (ISTH) pro...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2007.48.4.595

    authors: Lee JH,Song JW,Song KS

    更新日期:2007-08-31 00:00:00

  • Clinical observation study of massive blood transfusion in a tertiary care hospital in Korea.

    abstract:PURPOSE:Massive blood transfusios are uncommon. The goal of this study was to propose an ideal ratio for the blood component of massive hemorrhage treatment after review of five years of massive transfusion practice, in order to have the best possible clinical outcomes. MATERIALS AND METHODS:We defined a 'massive tran...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2011.52.3.469

    authors: Yoon S,Park AJ,Kim HO

    更新日期:2011-05-01 00:00:00

  • Diurnal variation of pulse wave velocity assessed non-invasively by applanation tonometry in young healthy men.

    abstract:PURPOSE:Pulse wave velocity (PWV) is at least partially controlled by vascular tone. Vascular tone and underlying physiological processes such as sympathetic activity, plasma catecholamin, and cortisol levels have been shown to follow diurnal variations. MATERIALS AND METHODS:Carotid-to-radial PWV was non-invasively a...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2007.48.4.665

    authors: Bodlaj G,Berg J,Biesenbach G

    更新日期:2007-08-31 00:00:00

  • Meningitis due to bacillus anthracis.

    abstract::The first case of haemorrhagic meningitis due to Bacillus anthracis in the European part of Turkey is reported here. B. anthracis, sensitive to penicillin, was isolated from the cerebrospinal fluid and blood cultures. Although appropriate therapy was administered, the patient died two days after hospitalization. ...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2005.46.1.159

    authors: Gürcan S,Akata F,Kuloğlu F,Erdoğan S,Tuğrul M

    更新日期:2005-02-28 00:00:00

  • Tissue engineering in the twenty-first century.

    abstract::In the 20th century, free tissue transfers have been successfully introduced using microvascular anastomosis techniques. Transplants not only include whole organs such as the kidney, liver and lung, but also bone, muscle and skin. However, there are a limited number of organs available for transplantation. This leads ...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章,评审

    doi:10.3349/ymj.2000.41.6.685

    authors: Terada S,Sato M,Sevy A,Vacanti JP

    更新日期:2000-12-01 00:00:00