The role of H1- and H2-receptors in the effect of compound 48/80 in the asphyxiation and body temperature of mice.

Abstract:

:Contribution of histamine H1- and H2-receptors to the effect of compound 48/80, a potent histamine releaser, upon asphyxiation and body temperature in mice was investigated in the present experiments. Compound 48/80 showed an apparent protective potency against hypoxia and significantly prolonged the latencies for convulsions and death in a dose-dependent manner. Compound 48/80 also decreased the body temperature, which was in relation with the antihypoxic effect. Both the H1-receptor antagonist, dimethindene, and the H2-receptor antagonist, ranitidine, attenuated the hypothermic effect of compound 48/80, indicating the involvement of central histamine through both the H1- and H2-receptors. Ranitidine had no effect on the protective effect of compound 48/80 against hypoxia-induced lethality, whereas dimethindene completely antagonized it. These results suggest that the protective effect of compound 48/80 against hypoxia is mediated through histamine H1-receptors and is not related to its ability to induce hypothermia.

journal_name

Yonsei Med J

journal_title

Yonsei medical journal

authors

Ulugöl A,Karadag H,Dökmeci D,Dökmeci I

doi

10.3349/ymj.1996.37.2.97

subject

Has Abstract

pub_date

1996-04-01 00:00:00

pages

97-103

issue

2

eissn

0513-5796

issn

1976-2437

journal_volume

37

pub_type

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