Abstract:
PURPOSE:Exclusive enteral nutrition (EEN) therapy effectively induces clinical remission in Crohn's disease (CD). It remains unclear, however, whether partial enteral nutrition (PEN) can maintain remission. This study was performed to determine the abilities of oral EEN and oral PEN to induce and maintain clinical remission in pediatric patients with CD, respectively. MATERIALS AND METHODS:Pediatric patients with CD who received oral EEN at a single center in 2000-2014 were identified retrospectively. Remission rates of the EEN and PEN during the 2 years study period were determined. Risk factors for EEN and PEN failure were identified. RESULTS:Of the 66 patients who started EEN, 61 (92%) completed the course. Clinical remission was achieved in 88% (58/66) of the patients. All 58 patients with remission continued with PEN: 43 (74%) were treatment adherent. The cumulative remission rates at 1 and 2 years were 67% and 52%, respectively. Differing from EEN, limited therapeutic efficacy of PEN was shown in severe CD patients. Female gender associated significantly with non-adherence. CONCLUSION:Oral EEN and PEN effectively induced and maintained remission in a pediatric population. Non-adherence was a limiting factor in the success of therapy.
journal_name
Yonsei Med Jjournal_title
Yonsei medical journalauthors
Kim HJ,Kim Y,Cho JM,Oh SH,Kim KMdoi
10.3349/ymj.2016.57.5.1185subject
Has Abstractpub_date
2016-09-01 00:00:00pages
1185-91issue
5eissn
0513-5796issn
1976-2437pii
57.1185journal_volume
57pub_type
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章,随机对照试验
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