Aldehyde Dehydrogenase 2 (ALDH2) Polymorphism and the Risk of Alcoholic Liver Cirrhosis among East Asians: A Meta-Analysis.

Abstract:

PURPOSE:The aldehyde dehydrogenase 2 (ALDH2) gene has been implicated in the development of alcoholic liver cirrhosis (ALC) in East Asians. However, the results are inconsistent. In this study, a meta-analysis was performed to assess the associations between the ALDH2 polymorphism and the risk of ALC. MATERIALS AND METHODS:Relevant studies were retrieved by searching PubMed, Web of Science, CNKI, Wanfang and Veipu databases up to January 10, 2015. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using either the fixed- or random effects model. RESULTS:A total of twelve case-control studies included 1003 cases and 2011 controls were included. Overall, the ALDH2 polymorphism was associated with a decreased risk of ALC (*1/*2 vs. *1/*1: OR=0.78, 95% CI: 0.61-0.99). However, in stratification analysis by country, we failed to detect any association among Chinese, Korean or Japanese populations. CONCLUSION:The pooled evidence suggests that ALDH2 polymorphism may be an important protective factor for ALC in East Asians.

journal_name

Yonsei Med J

journal_title

Yonsei medical journal

authors

He L,Deng T,Luo H

doi

10.3349/ymj.2016.57.4.879

subject

Has Abstract

pub_date

2016-07-01 00:00:00

pages

879-84

issue

4

eissn

0513-5796

issn

1976-2437

pii

57.879

journal_volume

57

pub_type

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