Abstract:
PURPOSE:The aldehyde dehydrogenase 2 (ALDH2) gene has been implicated in the development of alcoholic liver cirrhosis (ALC) in East Asians. However, the results are inconsistent. In this study, a meta-analysis was performed to assess the associations between the ALDH2 polymorphism and the risk of ALC. MATERIALS AND METHODS:Relevant studies were retrieved by searching PubMed, Web of Science, CNKI, Wanfang and Veipu databases up to January 10, 2015. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using either the fixed- or random effects model. RESULTS:A total of twelve case-control studies included 1003 cases and 2011 controls were included. Overall, the ALDH2 polymorphism was associated with a decreased risk of ALC (*1/*2 vs. *1/*1: OR=0.78, 95% CI: 0.61-0.99). However, in stratification analysis by country, we failed to detect any association among Chinese, Korean or Japanese populations. CONCLUSION:The pooled evidence suggests that ALDH2 polymorphism may be an important protective factor for ALC in East Asians.
journal_name
Yonsei Med Jjournal_title
Yonsei medical journalauthors
He L,Deng T,Luo Hdoi
10.3349/ymj.2016.57.4.879subject
Has Abstractpub_date
2016-07-01 00:00:00pages
879-84issue
4eissn
0513-5796issn
1976-2437pii
57.879journal_volume
57pub_type
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